The Caudate Nucleus: Its Connections, Surgical Implications, and Related Complications

Çırak, Musa; Yağmurlu, Kaan; Kearns, Kathryn N.; Ribas, Eduardo Carvalhal; Urgun, Kamran; Shaffrey, Mark E.; Kalani, M. Yashar S.

doi:10.1016/j.wneu.2020.04.027

Cited by 27 publications

(19 citation statements)

References 64 publications

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“…Caudate is a part of the cortico-striato-thalamo-cortical loop, which is involved in the hyperkinetic and hypokinetic movement disorders and mental disorders ( ırak et al, 2020 ). Chen et al (2020) identified significant decreasing mean fractional amplitude of low-frequency fluctuation trend in the left caudate in the CT (-) group compared with the CT (+) group in the population with breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy

Zhang

Shang

et al. 2022

Front. Mol. Biosci.

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Purpose: This study was performed to investigate the regional cerebral blood flow (CBF) and CBF connectivity in the chemotherapy-induced cognitive impairment of patients with lung cancer by using arterial spin labeling.Methods: Pseudocontinuous arterial spin labeling perfusion magnetic resonance imaging and neuropsychological tests were performed for 21 patients with non-small cell lung cancer who had received chemotherapy CT (+) and 25 non-small cell lung cancer patients who need chemotherapy but did not yet received CT (-). The CT (+) group previously received platinum-based therapy for 3 months to 6 months (the time from their first chemotherapy to the MRI scan). Group comparisons were performed in the regional normalized CBF and CBF connectivity, and the relationship between the regional normalized CBF and cognitive impairment were detected.Results: The CT (+) group exhibited higher CBF in the left insula, right caudate, right superior occipital gyrus, left superior temporal gyrus (STG), and right middle frontal gyrus (MFG). MoCA scores as well as the memory scores were negatively correlated with the increased CBF in the right MFG (r = −0.492, p = 0.023; r = −0.497, p = 0.022). Alterations in the CBF connectivity were detected only in the CT (+) group between the following: right MFG and the right precentral gyrus; the right caudate and the right lingual gyrus; right caudate and right precuneus; left STG and the bilateral MFG; and the left STG and the right middle cingulum.Conclusion: These findings indicated that chemotherapy is associated with abnormalities in the CBF and connectivity alterations, which may contribute to the cognitive impairment in patients with lung cancer.

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Section: Discussionmentioning

confidence: 99%

Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy

Zhang

Shang

et al. 2022

Front. Mol. Biosci.

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“… 25 There is an increasing number of reports that functional and structural abnormalities in the caudate nucleus are present in patients with hyperkinetic and hypokinetic movement disorders (e.g., Parkinson’s and Huntington’s diseases). 26 , 27 The coordination of motor and visual cortices plays an important role in visuomotor function. 28 Additionally, a recent analysis revealed that patients with DR had abnormal intranetwork FCs in the bilateral thalamus and right caudate nucleus of the basal ganglia network, suggesting that DR patients may exhibit movement control dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy

Qi¹,

Huang²,

Tong³

et al. 2021

DMSO

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The purpose of the study was to find the differences in intrinsic functional connectivity (FC) patterns of the primary visual area (V1) among diabetic retinopathy (DR), diabetes mellitus (DM), and healthy controls (HCs) applying resting-state functional magnetic resonance imaging (rs-fMRI). Patients and Methods: Thirty-five subjects with DR (18 males and 17 females), 22 DM (10 males and 12 females) and 38 HCs (16 males and 22 females) matched for sex, age, and education underwent rs-fMRI scanning. Seed-based FC analysis was performed to find the alterations in the intrinsic FC patterns of V1 in DR compared with DM and HCs. Results: The study found that DR patients had a significant lower FC between the bilateral calcarine (CAL)/left lingual gyrus (LING) (BA 17/18) and the left V1, and between the bilateral CAL/left LING (BA 17/18) and the right V1 compared with the HCs. Meanwhile, patients with DR exhibited higher FC strength between the left V1 and the bilateral Caudate/ Olfactory/Orbital superior frontal gyrus (OSFG), and between the bilateral Caudate/ Olfactory/OSFG (BA 3/4/6) and the right V1. Compared with DM group, patients with DR showed increased FC strength between the right CAL (BA 17/18) and the right V1. DM group exhibited lower FC strength between the left fusiform and the left V1, and between the bilateral CAL and the right V1 when compared with HCs. Moreover, DM group was observed to have higher FC strength between the left superior frontal gyrus and the left V1. Conclusion: Our findings indicated that DR patients exhibited FC disruptions between V1 and higher visual regions at rest, which may reflect the aberrant information communication in the V1 area of DR individuals. The findings offer important insights into the neuromechanism of vision disorder in DR patients.

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“…The caudate nucleus is an important component of the corpus striatum, which controls spatial movement (35), spatial mnemonic processing, procedural learning (36), and associative learning (37). As part of the cortico-basal ganglia-thalamic loop, it also functions as a component of the reward system (38).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Altered Spontaneous Brain Activities in Patients With Moyamoya Disease Using Percent Amplitude of Fluctuation Method: A Resting-State Functional MRI Study

Shu

et al. 2021

Front. Neurol.

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Background: Moyamoya disease (MMD) is a chronic progressive cerebrovascular abnormality characterized by chronic occlusion of large intracranial vessels with smoky vascular development at the base of the skull. In patients with MMD, abnormal spontaneous brain activity would be expected.Purpose: To assess the brain activity changes in patients with MMD by resting-state functional MRI (rs-fMRI), using the percent amplitude of fluctuation (PerAF) analysis method.Materials and Methods: A total of 17 patients with MMD (3 males and 14 females) and 17 healthy control (HC) subjects with matched gender and age were recruited for this study. We used rs-fMRI to scan all the patients with MMD. Spontaneous neural activity was evaluated using the PerAF approach. The receiver operating characteristic (ROC) curve analysis was used to assess the ability of the PerAF to distinguish patients with MMD from HCs. The Hospital Anxiety and Depression Scale (HADS) tests were performed to assess the emotional status of patients with MMD and retinal nerve fiber layer thickness (RNFLT) was measured using high-resolution optical coherence tomography (hr-OCT). The relationship between the HADS scores, RNFLT values, and the PerAF signals was assessed using the Pearson's correlation analysis.Results: Compared with HCs, the PerAF signals in patients with MMD were decreased in the Frontal_Sup_Medial_R and Precentral_L, whereas those in the Caudate_L were increased. The areas under the ROC curves indicated that signals in these brain regions could distinguish between patients with MMD and HCs. The PerAF value of Frontal_Sup_Medial_R was positively correlated with the left and right eye RNFLT values and negatively correlated with the HADS scores.Conclusion: In patients with MMD, reduced PerAF signals in the Frontal_Sup_Medial_R, Precentral_L, and Caudate_L may be associated with psychiatric diseases including anxiety and depression and decreased RNFLT may be associated with ophthalmic complications due to the compression of terminal branches of the internal carotid artery in the retinal fiber layer. The PerAF can be used as an effective indicator of ocular complications of MMD and to study the neural mechanism underpinning emotional complications in patients with MMD.

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The Caudate Nucleus: Its Connections, Surgical Implications, and Related Complications

Cited by 27 publications

References 64 publications

Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy

Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy

Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy

Investigation of Altered Spontaneous Brain Activities in Patients With Moyamoya Disease Using Percent Amplitude of Fluctuation Method: A Resting-State Functional MRI Study

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