The present article reports a systematic literature review of intervention studies using Virtual Reality (VR) in sports contexts. It provides a qualitative overview and descriptive synthesis of such studies in order to clarify the potential benefits of this technology for sports performance enhancement. Possible applications include training of motor and psychological skills and capabilities in athletes, including perception-action skills, strategic, tactical and decision-making, responding to unexpected events, and enhancing psychological resilience and mental performance under pressure.Our systematic literature search and review included original intervention studies only. Theses, newspaper articles, comments, and opinion papers were excluded. This eventually resulted in twelve VR intervention studies (using a variety of VR systems) focused on different sports, including target and precision sports (e.g., archery, bowling, curling, darts, golf), bat/racquet and ball sports (e.g., baseball, table tennis), goal sports (e.g., football/soccer, basketball), martial arts (e.g., karate), and sport-unspecific processes such as bodily sensations, pain intensity, balancing, and psychological strategies. The samples investigated in the primary studies included novice, amateur, and expert athletes (total aggregated sample size N = 493).Many studies found statistically significant effects in relevant target skills following interventions in VR, often outperforming training effects in passive or active control conditions (e.g., using conventional training protocols). Therefore, interventions in VR have the potential to elicit real effects in sports performance enhancement. Some of the neurocognitive mechanisms (e.g., visual search behavior, imagery), and methodological aspects (e.g., adaptive training difficulty) via which these sports-performance-related improvements may occur are discussed. Due to the heterogeneity of included studies, however, general recommendations for applied sports practice are premature. Finally, limitations of the included studies as well as the present review and future perspectives are taken into consideration.