The causal effect of oxidative stress on the risk of glaucoma

Shi, Ronghua; Wu, Yaxuan; Chen, He; Zhang, Zicheng; Bao, Siqi; Qu, Jia; Zhou, Meng

doi:10.1016/j.heliyon.2024.e24852

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e24852

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The causal effect of oxidative stress on the risk of glaucoma

Ronghua Shi,

Yaxuan Wu,

He Chen

et al.

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Cited by 3 publications

References 61 publications

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Structural characterization and protective effect against oxidative stress of Volvariella volvacea polysaccharide

Du,

Li,

Liu

et al. 2025

International Journal of Biological Macromolecules

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Structural characterization and protective effect against oxidative stress of Volvariella volvacea polysaccharide

Du,

Li,

Liu

et al. 2025

International Journal of Biological Macromolecules

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The Role of Changes in the Hydrogen Sulfide Level in Eye Tissues on the Development of Experimental Glaucoma

Mikheytseva,

Kolomiichuk,

Siroshtanenko

2024

Fiziol Zh

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The modern scientific direction in the study of the pathogenesis of primary glaucoma is searching for specific biomarkers and regulatory mechanisms of this disease. The aim of the work was to study the level of hydrogen sulfide in eye tissues in animals with adrenaline-induced glaucoma (AIG) and its relationship with intraocular pressure (IOP). The glaucoma model (first group) was induced by injecting 0.1 ml of adrenaline solution into the ear vein for 3 months. In the second group, animals (during AIG simulation) received a hydrogen sulfide donor - daily instillations of 1% NaHS solution into the eye. The third (control) group consisted of intact animals. After 3 months, the level of endogenous hydrogen sulfide was determined in the tissues of the drainage zone of the eye, retina, optic nerve, and intraocular fluid. Glaucoma modeling in rabbits was characterized by a dynamic increase in IOP. A decrease of hydrogen sulfide level in all eye tissues in glaucoma was established. The maximum decrease was observed in the retina by 37.3% when compared with the control. In the second group, the level of endogenous hydrogen sulfide was higher than in the first group in the tissues of the drainage zone by 54%, the retina by 42%, the optic nerve by 37%, and the intraocular fluid by 60%. A decrease and gradual normalization of IOP were found in the second group. The presence of an inverse Spearman correlation between IOP indicators and the level of hydrogen sulfide in all experimental groups was established. We suggest that the established facts confirm the hypothesis regarding the role of a gas transmitter hydrogen sulfide in the pathogenesis of glaucoma.

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Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea

Donkor,

Gardner,

Bradshaw

et al. 2024

Antioxidants

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Obstructive sleep apnea (OSA) is a sleep disorder characterized by intermittent complete or partial occlusion of the airway. Despite a recognized association between OSA and glaucoma, the nature of the underlying link remains unclear. In this study, we investigated whether mild OSA induces morphological, inflammatory, and metabolic changes in the retina resembling those seen in glaucoma using a rat model of OSA known as chronic intermittent hypoxia (CIH). Rats were randomly assigned to either normoxic or CIH groups. The CIH group was exposed to periodic hypoxia during its sleep phase with oxygen reduction from 21% to 10% and reoxygenation in 6 min cycles over 8 h/day. The eyes were subsequently enucleated, and then the retinas were evaluated for retinal ganglion cell number, oxidative stress, inflammatory markers, metabolic changes, and hypoxic response modulation using immunohistochemistry, multiplex assays, and capillary electrophoresis. Statistically significant differences were observed between normoxic and CIH groups for oxidative stress and inflammation, with CIH resulting in increased HIF-1α protein levels, higher oxidative stress marker 8-OHdG, and increased TNF-α. Pyruvate dehydrogenase kinase-1 protein was significantly reduced with CIH. No significant differences were found in retinal ganglion cell number. Our findings suggest that CIH induces oxidative stress, inflammation, and upregulation of HIF-1α in the retina, akin to early-stage glaucoma.

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The causal effect of oxidative stress on the risk of glaucoma

Cited by 3 publications

References 61 publications

Structural characterization and protective effect against oxidative stress of Volvariella volvacea polysaccharide

Structural characterization and protective effect against oxidative stress of Volvariella volvacea polysaccharide

The Role of Changes in the Hydrogen Sulfide Level in Eye Tissues on the Development of Experimental Glaucoma

Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea

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