2021
DOI: 10.1257/aer.20190221
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The Causal Interpretation of Two-Stage Least Squares with Multiple Instrumental Variables

Abstract: Empirical researchers often combine multiple instrumental variables (IVs) for a single treatment using two-stage least squares (2SLS). When treatment effects are heterogeneous, a common justification for including multiple IVs is that the 2SLS estimand can be given a causal interpretation as a positively weighted average of local average treatment effects (LATEs). This justification requires the well-known monotonicity condition. However, we show that with more than one instrument, this condition can only be s… Show more

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Cited by 80 publications
(59 citation statements)
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“…A major limitation of Lemma 3.1 and Theorem 3.2 is that empirical applications of IV methods rarely consider fully heterogeneous first stages and saturated specifications with discrete covariates. As mentioned above, in a survey of recent papers with multiple instruments, only 13% of applications interact covariates with an original instrument (Mogstad et al, 2020). Specifications using many overidentifying restrictions appear to have been more common in earlier work using IV methods (e.g., Angrist, 1990;Angrist and Krueger, 1991) but have effectively disappeared from empirical economics out of concern for weak instruments.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…A major limitation of Lemma 3.1 and Theorem 3.2 is that empirical applications of IV methods rarely consider fully heterogeneous first stages and saturated specifications with discrete covariates. As mentioned above, in a survey of recent papers with multiple instruments, only 13% of applications interact covariates with an original instrument (Mogstad et al, 2020). Specifications using many overidentifying restrictions appear to have been more common in earlier work using IV methods (e.g., Angrist, 1990;Angrist and Krueger, 1991) but have effectively disappeared from empirical economics out of concern for weak instruments.…”
Section: Resultsmentioning
confidence: 99%
“…Such specifications are very rare in empirical work. For example, in a survey of recent papers with multiple instruments, only 13% of applications use covariate interactions with an original instrument (Mogstad, Torgovitsky, and Walters, 2020). This severely limits the applicability of Angrist and Imbens (1995)'s result to interpreting actual IV and 2SLS estimates.…”
Section: Introductionmentioning
confidence: 99%
“…While we call τ * , τ * j , τ j (x) treatment effects here, we note that the causal interpretation of such quantities is not straightforward. Indeed, Mogstad et al (2019Mogstad et al ( , 2020 argue that estimating causal effects with multiple instruments requires more careful statements of assumptions and implied estimands, as well as alternative estimation strategies that go beyond simple (weighted) averages of two-stage least-squares estimates.…”
Section: Discussionmentioning
confidence: 99%
“…3 Pairwise validity can be viewed as a generalization of the partial monotonicity assumption of Mogstad et al (2021). See Remark 2.1 for a discussion.…”
Section: Introductionmentioning
confidence: 99%