The causal relationship between atopic dermatitis and brain cancer: A bidirectional Mendelian randomization study

BackgroundGrowing evidence has shown that atopic dermatitis (AD) may decrease lung cancer (LC) risk. However, the causality between the two diseases is inconsistent and controversial. Therefore, we explored the causal relationship between AD and different histological subtypes of LC by using the Mendelian randomization (MR) method.Materials and methodsWe conducted the MR study based on summary statistics from the genome‐wide association studies (GWAS) of AD (10,788 cases and 30,047 controls) and LC (29,266 cases and 56,450 controls). Instrumental variables (IVs) were obtained after removing SNPs associated with potential confounders. We employed inverse‐variance weighted (IVW), MR‐Egger, and weighted median methods to pool estimates, and performed a comprehensive sensitivity analysis.ResultsThe results of the IVW method suggested that AD may decrease the risk of developing lung adenocarcinoma (LUAD) (OR = 0.91, 95% CI: 0.85‐0.97, P = 0.007). Moreover, no causality was identified between AD and overall LC (OR = 0.96, 95% CI: 0.91–1.01, P = 0.101), lung squamous cell carcinoma (LUSC) (OR = 1.04, 95% CI: 0.96–1.036, P = 0.324), and small cell lung carcinoma (SCLC) (OR = 0.95, 95% CI: 0.82–1.10, P = 0.512). A comprehensive sensitivity test showed the robustness of our results.ConclusionThe present study indicates that AD may decrease the risk of LUAD in the European population, which needs additional investigations to identify the potential molecular mechanisms.

Section: Discussionmentioning

confidence: 99%

The causal effect of atopic dermatitis on lung cancer: A Mendelian randomization study

Huang,

Wen,

et al. 2024

“…However, the association between inflammatory diseases and systemic malignancies remains unclear. 1 , 2 Inflammatory skin diseases are characterized by chronic inflammation, immune dysregulation, and altered cytokine profiles. 3 Chronic inflammation has been recognized as a hallmark of cancer, contributing to tumor initiation, promotion, and progression.…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between inflammatory skin diseases and breast cancer: A bidirectional Mendelian randomization study

Yang,

Zhao

2024

IntroductionPrior research has explored the relationship between inflammatory skin disorders and breast cancer (BC), yet the causality of this association remains uncertain.MethodsUtilizing a bidirectional two‐sample Mendelian randomization (MR) approach, this study aimed to elucidate the causal dynamics between various inflammatory skin conditions—namely acne, atopic dermatitis, psoriasis vulgaris, urticaria, and rosacea—and BC. Genetic variants implicated in these disorders were sourced from comprehensive genome‐wide association studies representative of European ancestry. In the forward MR, BC was posited as the exposure, while the reverse MR treated each inflammatory skin disease as the exposure. A suite of analytical methodologies, including random effects inverse variance weighted (IVW), weighted median (WME), and MR‐Egger, were employed to probe the causative links between inflammatory skin diseases and BC. Sensitivity analyses, alongside evaluations for heterogeneity and pleiotropy, were conducted to substantiate the findings.ResultsThe MR analysis revealed an increased risk of acne associated with BC (IVW: OR = 1.063, 95% CI = 1.011–1.117, p = 0.016), while noting a decreased risk of atopic dermatitis (AD) in BC patients (IVW: OR = 0.941, 95% CI = 0.886–0.999, p = 0.047). No significant associations were observed between BC and psoriasis vulgaris, urticaria, or rosacea. Conversely, reverse MR analyses detected no effect of BC on the incidence of inflammatory skin diseases. The absence of pleiotropy and the consistency of these outcomes strengthen the study's conclusions.ConclusionFindings indicate an elevated incidence of acne and a reduced incidence of AD in individuals with BC within the European population.

Causal relationship between inflammatory skin diseases and immunoglobulin A nephropathy: A Mendelian randomization and enrichment analysis study

Li,

Wang,

Han

et al. 2024

ObjectiveTo investigate the causal relationship between inflammatory skin diseases (atopic dermatitis, and psoriasis) and IgA nephropathy using Mendelian randomization and enrichment analysis.MethodsThe instrumental variables (IVs) in the European Bioinformatics Institute (EBI) database were used for two‐sample MR analysis. The results of inverse variance weighting (IVW) were used as the main method, the MR−Egger method was used for pleiotropy analysis and the leave‐one‐out method was used for sensitivity analysis to verify the reliability of the data. Combined with the human genome database GeneCards database and Metascape enrichment analysis.ResultsPeople with AD had an increased risk of IgA nephropathy (IVW: OR = 1.06, 95% CI [1.0002–1.1248], p = 0.0491). Psoriasis and IgA nephropathy (IVW: OR = 0.97, 95% CI [0.9394–1.0055], p = 0.1002) no statistical significance, therefore cannot prove cause‐and‐effect relationship between.ConclusionsThis study provides evidence that atopic dermatitis is associated with an increased risk of IgA nephropathy, but does not provide evidence that psoriasis is causologically associated with IgA nephropathy. Enrichment analysis suggested a causal relationship between inflammatory skin diseases and IgA nephropathy at the genetic level.