2024
DOI: 10.1097/md.0000000000037355
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The causal relationship between severe mental illness and risk of lung carcinoma

Xiaohan Chen,
Shudan Wang,
Weiyu Shen

Abstract: Observational studies have suggested a link between severe mental illness (SMI) and risk of lung carcinoma (LC); however, causality has not been established. In this study, we conducted a two-sample, two-step Mendelian randomization (MR) investigation to uncover the etiological influence of SMI on LC risk and quantify the mediating effects of known modifiable risk factors. We obtained summary-level datasets for schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD) from the Psychiatric Genom… Show more

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