The Cause of Death in Strangulation Obstruction

Nemir, Paul; Hawthorne, Herbert R.; Cohn, Isidore; Drabkin, David L.

doi:10.1097/00000658-194911000-00002

Cited by 30 publications

(3 citation statements)

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“…The importance of the bacterial factors in strangulation obstruction has been stressed by several workers (1-9, 13-15) but there is some discussion whether additional factors are needed (7,(13)(14)(15). Barnett and Clippinger (23) showed in 1959 that the survival time of dogs with closed loop strangulation obstruction increased by a factor of 2 (from 29 to 56 hours) by the administration of penicillin.…”

Section: Discussionmentioning

confidence: 99%

Results of Experimental Intestinal Strangulation Obstruction in Germfree Rats

Amundsen

Gustafsson

1963

The Journal of Experimental Medicine

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Numerous factors influence the pathological physiology of intestinal strangulation obstruction. Those originating from the strangulation fluid, i.e. the fluid produced b y the strangulated loop of intestine, have been a focus of interest for experimental studies during the past few years. This fluid is very toxic on intraperitoneal injection in healthy animals (1-3). Antibiotics diminish the toxicity (4-6) and there are findings which indicate that the content of Escherichia coli and of red blood cells in the strangulation fluid influence the toxicity of the fluid (7). The decisive influence attributed to the intestinal bacteria on the toxicity of the strangulation fluid (8, 9) prompted the following experiments in which clinical course, survival time, and toxicity of strangulation fluid were noted on germfree rats and conventional rats with experimentally produced low ileal strangulation obstruction.

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Section: Discussionmentioning

confidence: 99%

Results of Experimental Intestinal Strangulation Obstruction in Germfree Rats

Amundsen

Gustafsson

1963

The Journal of Experimental Medicine

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“…This exudate is called strangulation fluid ( 3 ) . Strangulation fluid collected during the first 18-24 hour period is sterile, whilc fluid collected latcr contains large numbers of bacteria (3, 16). T h e infected strangulation fluid is fatal to healthy animals when injected into the peritoneal cavity in small quantities (4, 8).…”

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confidence: 99%

Host Defence Reactions During Intestinal Strangulation Obstruction in Germfree Rats

Trippestad¹,

Midtvedt²

1970

Acta Pathologica Microbiologica Scandinavica Section B Microbio

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Exudate was collected from germfree rats subjected to experimrntal intestinal strangulation obstruction. The exudate, called strangulation fluid, was non-lethal when injected into the peritoneal cavity of mice. The fluid was found to enhance the virulence of E. coli towards mice. Strangulation fluid from germfree rats appeared to contain less opsonic and bactericidal properties than serum from germfree rats towards E. coli. The fluid appeared to inactivate the opsonic and bactericidal activity of conventional rat scrum to a substantial degree.

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“…The inability of the abnormal pigment to be deoxygenated by dithionite has been cited as an extraordinary property for a derivative of hemoglobin occurring in vivo (1). The behavior of the reduced cyanmethemoglobin derivat.ive is analogous to that of the monocyanide derivative of an oxidized hemochromogen, but is not identical.…”

mentioning

confidence: 99%