The Cause of Death in High Obstruction

Cooper, Henry S.

doi:10.1001/archsurg.1928.01140120022002

Cited by 27 publications

(2 citation statements)

References 91 publications

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“…Filtrates and certain extracts of the bowel contents from above the point of obstruction are extremely toxic when injected into animals, and many attempts have been made to isolate and identify the substance, or substances, responsible for this toxicity. A review of this work may be found in the article by Cooper (1928). Whipple and his collaborators (1916) believed the toxic substances to be of proteose nature, while Gerard (1922) and others have pointed out the similarity in the pharmacologic effects of these extracts and of histamine.…”

Section: Intestinal Obstruction: Toxemiamentioning

confidence: 99%

Chemical Studies of the Blood in High Intestinal Obstruction

Andrus

Guest²,

Gates³

et al. 1932

J. Clin. Invest.

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In the preceding paper (Guest and Andrus, 1932) certain of the principal changes occurring in the blood of dogs following simple pyloric or mid-duodenal obstruction have been discussed. Experiments were reported in which the distribution of phosphorus in the blood of dogs with obstruction was determined, and changes in various fractions of the blood phosphorus were correlated with other chemical changes of the blood which are generally known to be associated with intestinal obstruction. The greatest change in the blood phosphorus was in that fraction designated as the "organic acid-soluble ester-P" practically all of which is contained in the cells. Changes in the chloride content of both plasma and cells were compared with concomitant changes in the distribution of phosphorus, and a close correlation between the progressive losses of chloride from the blood cells and the increases of the ester-P of the cells was demonstrated. From these findings it was concluded that in the acid-base equilibrium of the cells these organic phosphorus compounds had some sort of a reciprocal relationship to the cell chloride, and that as these phosphorus compounds increased they were bound to the alkali in the cells from which chloride was lost, much as HCO3' is known to be retained by the alkali of the blood from which Cl' is lost. In those experiments it was also shown that the parenteral administration of NaCl solution prevented increases of ester-P in the cells to about the same degree that it prevented losses of chloride.The two theories most commonly accepted in explanation of the cause of death in intestinal obstruction are: (1) that death is due to dehydration and disturbance of the acid-base equilibrium of the body which follows the loss of electrolytes and water by vomiting and by failure of reabsorption of gastro-intestinal secretions from the obstructed bowel; (2) that death is due to a state of intoxication of the tissues brought about by toxic substances absorbed from the obstructed bowel. 475

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Section: Intestinal Obstruction: Toxemiamentioning

confidence: 99%

Chemical Studies of the Blood in High Intestinal Obstruction

Andrus

Guest²,

Gates³

et al. 1932

J. Clin. Invest.

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“…Reviews of the many investigations of intestinal obstruction may be found in the articles by Ellis (1922), Gatch, Trusler and Ayers (1927), Cooper (1928), McVicar and Weir (1929) and in three papers of a sym-posium on the subject by Foster (1928), Orr and Haden (1928), and McIver and Gamble (1928).…”

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Chemical Studies of the Blood in High Intestinal Obstruction 1

Guest

Andrus²

1932

J. Clin. Invest.

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This paper presents an investigation of the effects of experimental high intestinal obstruction in dogs, with particular emphasis on changes observable in the distribution of phosphorus in the blood. The experiments were undertaken as a part of a series of studies of phosphorus distribution in the blood of man and experimental animals in a variety of pathologic conditions. In dogs, marked changes of the distribution of phosphorus were observed following pyloric and mid-duodenal obstruction; an attempt is here made to correlate these changes with the variations in the blood electrolytes commonly observed in intestinal obstruction.

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Experimental Low Colonic Obstruction

Roberts¹

1932

Arch Intern Med

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The Cause of Death in High Obstruction

Cited by 27 publications

References 91 publications

Chemical Studies of the Blood in High Intestinal Obstruction

Chemical Studies of the Blood in High Intestinal Obstruction

Chemical Studies of the Blood in High Intestinal Obstruction 1

Experimental Low Colonic Obstruction

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