1931
DOI: 10.1126/science.74.1914.244
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The Cause of Mottled Enamel

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Cited by 41 publications
(14 citation statements)
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“…For example, fluoride is present in almost all freshwaters (Hem 1985;Brunt et al 2004;Ozsvath 2009), but in extreme cases natural concentrations can exceed 1000 mg/L (Jones et al 1977), which is far in excess of the World Health Organization's limit for fluoride in drinking water of 1.5 mg/L (WHO 2017). The deleterious effects on human health of drinking water with high fluoride concentration have been known since the early nineteenth century (Smith et al 1931).…”
Section: Geologymentioning
confidence: 99%
“…For example, fluoride is present in almost all freshwaters (Hem 1985;Brunt et al 2004;Ozsvath 2009), but in extreme cases natural concentrations can exceed 1000 mg/L (Jones et al 1977), which is far in excess of the World Health Organization's limit for fluoride in drinking water of 1.5 mg/L (WHO 2017). The deleterious effects on human health of drinking water with high fluoride concentration have been known since the early nineteenth century (Smith et al 1931).…”
Section: Geologymentioning
confidence: 99%
“…I ts presence in drinking water is a matter of regional importance in connection with the problem of mottled enamel in at least 25 states (51,52). Mottled enamel of the teeth of children occurs when water contains 0.9 mg. per liter or more; a 75-80 per cent incidence is found when the fluorine content is 2.5 mg. per liter, and at 6 mg. per liter the incidence is 100 per cent (53,54). Fluorine is widely distributed i~nature and is present in practically all biological material, foods containing on an average approximately 0.8 ppm.…”
Section: Non-nutritive Toxic Trace Ele-mentioning
confidence: 99%
“…Dental fluorosis is a disorder caused by chronic excessive fluoride intake during the period of the development of the teeth 1 . In 1931, three different scientific groups, working in different locations around the world, discovered the correlation between the fluoride content in drinking water and dental fluorosis [2][3][4] .…”
Section: Introductionmentioning
confidence: 99%
“…Dean's Index 18 rates the clinical image of the two most affected teeth. As a result, based on the severity, the case is rated as normal (0), questionable (0.5), very mild (1), mild (2), moderate (3) and severe (4). In questionable dental fluorosis there are minor aberrations from the usual translucency of the enamel, while opaque, paperwhite areas are typical findings in very mild (<25% of the surface), mild (25<x<50% of the surface) and moderate dental fluorosis (100% of the surface).…”
Section: Introductionmentioning
confidence: 99%