The causes and prevention of cancer: gaining perspective.

Ames, Bruce N.; Gold, Lois Swirsky

doi:10.1289/ehp.97105s4865

Cited by 70 publications

(14 citation statements)

References 102 publications

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“…It is known that damage of the genetic material plays a key role in the etiology of cancer [ 5 , 6 , 7 ], therefore, we investigated for the first time the effects of the universal mobile telecommunication system (UMTS) signal on DNA stability in human glioblastoma cell lines (U87, U251 and U373). Additionally, we included further human nerve tissue derived cell lines i.e.…”

Section: Introductionmentioning

confidence: 99%

Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells

et al. 2018

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Some epidemiological studies indicate that the use of mobile phones causes cancer in humans (in particular glioblastomas). It is known that DNA damage plays a key role in malignant transformation; therefore, we investigated the impact of the UMTS signal which is widely used in mobile telecommunications, on DNA stability in ten different human cell lines (six brain derived cell lines, lymphocytes, fibroblasts, liver and buccal tissue derived cells) under conditions relevant for users (SAR 0.25 to 1.00 W/kg). We found no evidence for induction of damage in single cell gel electrophoresis assays when the cells were cultivated with serum. However, clear positive effects were seen in a p53 proficient glioblastoma line (U87) when the cells were grown under serum free conditions, while no effects were found in p53 deficient glioblastoma cells (U251). Further experiments showed that the damage disappears rapidly in U87 and that exposure induced nucleotide excision repair (NER) and does not cause double strand breaks (DSBs). The observation of NER induction is supported by results of a proteome analysis indicating that several proteins involved in NER are up-regulated after exposure to UMTS; additionally, we found limited evidence for the activation of the γ-interferon pathway. The present findings show that the signal causes transient genetic instability in glioma derived cells and activates cellular defense systems.

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Section: Introductionmentioning

confidence: 99%

Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells

et al. 2018

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“…We found in a recent investigation with human-derived cells that some of them cause damage of the genetic material, while other toxic effects (acute cytotoxicity, immunological effects and estrogenic properties) were only moderate or lacking (Koller et al 2013, 2014). Genetic damage is involved in etiology of various diseases, i.e., it plays a key role in the induction of cancer and is also involved in neurodegenerative disorders, atherosclerosis, infertility and aging (Ames and Gold 1997; Ames et al 1993). Therefore, our previous findings indicate that adverse effects, which are related to DNA damage, may be induced in users of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4

et al. 2016

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Aim of this study was the investigation of the genotoxic properties of XLR-11 [1-(5-fluoropentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone, a widely consumed synthetic cannabinoid (SC), and of the benzoyl indole RCS-4 (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone). We characterized the DNA-damaging properties of these drugs in different experimental systems. No evidence for induction of gene mutations was detected in bacterial (Salmonella/microsome) tests, but clear dose-dependent effects were found in in vitro single cell gel electrophoresis (SCGE) assays with human lymphocytes and with buccal- and lung-derived human cell lines (TR-146 and A-549). These experiments are based on the determination of DNA migration in an electric field and enable the detection of single- and double-strand breaks and apurinic sites. Furthermore, we found that both drugs induce micronuclei which are formed as a consequence of chromosomal aberrations. The lack of effects in SCGE experiments with lesion-specific enzymes (FPG, Endo III) shows that the DNA damage is not caused by formation of oxidatively damaged bases; experiments with liver enzyme homogenates and bovine serum albumin indicate that the drugs are not converted enzymatically to DNA-reactive intermediates. Furthermore, results with buccal- and lung-derived human cells show that gaseous treatment of the cells under conditions which reflect the exposure situation in drug users may cause damage of the genetic material in epithelia of the respiratory tract. Since DNA instability is involved in the etiology of cancer, these findings can be taken as an indication that consumption of the SCs may cause tumors in the respiratory tract of consumers.

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“…10 – 12 During approximately the past decade, the associations between coffee consumption and many diseases, including hypertension, cardiovascular diseases, and cancer, have been studied, and its effects have been found to be harmful to health. 13 , 14 However, several recent prospective cohort studies have indicated that coffee consumption lowers the risks of diabetes mellitus (DM), cardiovascular diseases, and cancer. 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

Relationship Between Coffee Consumption and Prevalence of Metabolic Syndrome Among Japanese Civil Servants

Matsuura

Mure

Nishio

et al. 2012

Journal of Epidemiology

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BackgroundMetabolic syndrome has become a major worldwide public health problem. We examined the relationship between coffee consumption and the prevalence of metabolic syndrome among Japanese civil servants.MethodsThe study participants were 3284 employees (2335 men and 948 women) aged 20 to 65 years. Using data from their 2008 health checkup records, we analyzed the relationship between coffee consumption and the prevalence of metabolic syndrome. Metabolic syndrome was defined according to the Japanese criteria.ResultsMetabolic syndrome was diagnosed in 374 of the 2335 men (16.0%) and 32 of the 948 women (3.4%). In univariate and multiple logistic regression analyses, the odds ratios (ORs) among men for the presence of metabolic syndrome were 0.79 (95% CI: 0.56–1.03) and 0.61 (0.39–0.95), respectively, among moderate (≥4 cups of coffee per day) coffee drinkers as compared with non-coffee drinkers. Among all components of metabolic syndrome, high blood pressure and high triglyceride level were inversely associated with moderate coffee consumption in men, after adjusting for age, body mass index, smoking status, drinking status, and exercise. However, in women, moderate coffee consumption was not significantly associated with the prevalence of metabolic syndrome or its components.ConclusionsModerate coffee consumption was significantly associated with lower prevalence of metabolic syndrome in Japanese male civil servants.

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The causes and prevention of cancer: gaining perspective.

Abstract: 865-873 (1997)

Cited by 70 publications

References 102 publications

Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells

Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells

Genotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4

Relationship Between Coffee Consumption and Prevalence of Metabolic Syndrome Among Japanese Civil Servants

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