The causes of dilated cardiomyopathy: A clinicopathologic review of 673 consecutive patients

Abstract

Idiopathic dilated cardiomyopathy is a common cause of congestive heart failure. Specific heart muscle diseases occur with much less frequency.

Estudo comparativo do anel valvar mitral e do ventrículo esquerdo na cardiomiopatia dilatada

“…O conhecimento das alterações do aparelho valvar mitral tem aplicabilidade direta no aprimoramento das diversas técnicas de correção cirúrgica que intervêm sobre o anel, as cúspides, as cordas tendíneas e os músculos papilares, em associações ou isoladamente, justificando seu estudo anatômico na cardiomiopatia dilatada (9,10) . O GRUPO II com 20 corações de cadáveres humanos, fixados, oriundos de cadáveres sem cardiopatia prévia cuja "causa mortis" foi o trauma.…”

“…O GRUPO II com 20 corações de cadáveres humanos, fixados, oriundos de cadáveres sem cardiopatia prévia cuja "causa mortis" foi o trauma. Para caracterizar os corações com CMD utilizaramse critérios (10,11) :…”

Contemporary Management of Atrial Fibrillation: Update on Anticoagulation and Invasive Management Strategies

“…The prevalence has not been clearly determined, but a study involving a series of 673 patients with dilated cardiomyopathy found that only 1 case of AF was caused by tachycardia. 59 Atrial fibrillation may not only cause the cardiomyopathy but may also exacerbate the symptoms of heart failure as a result of diastolic filling abnormalities and tachycardia-induced systolic dysfunction. Various cellular mechanisms have been implicated as causes of tachycardia-mediated cardiomyopathy, including the depletion of myocardial energy stores by chronic tachycardia, which causes oxidative stress and injury and leads to abnormal calcium handling and β-adrenergic responsiveness.…”

Beyond membrane channelopathies: alternative mechanisms underlying complex human disease

“…Specific mutations in the LMNA gene can result in isolated cardiac involvement in which the affected individuals develop dilated cardiomyopathy with or without conduction system disease. Dilated cardiomyopathy is a disorder of the myocyte characterized by cardiac dilation and systolic dysfunc tion [49,50] . Lamin mutations are likely the most common cause of idiopathic dilated cardiomyopathies.…”