The CC chemokine CCL20 and its receptor CCR6

Schutyser, Evemie; Struyf, Sofie; Damme, Jozef Van

doi:10.1016/s1359-6101(03)00049-2

Cited by 682 publications

(672 citation statements)

References 133 publications

Supporting

Mentioning

629

Contrasting

Unclassified

Order By: Relevance

“…CCL20, the only chemokine known to interact with CCR6, is physiologically expressed at epithelial surfaces (46) and fibroblast-like synoviocytes (29) and is up-regulated in inflammatory conditions (30,46). These findings suggest that CCR6 might have some roles in determining the physiologic distribution of IL-17-producing ␥/␦ T cells.…”

Section: Discussionmentioning

confidence: 92%

Gamma/delta T cells are the predominant source of interleukin‐17 in affected joints in collagen‐induced arthritis, but not in rheumatoid arthritis

Ito

Usui

Kobayashi

et al. 2009

Arthritis & Rheumatism

148

125

View full text Add to dashboard Cite

Objective. Although interleukin-17 (IL-17Methods. IL-17-producing cells in the affected joints of mice with CIA were counted by intracellular cytokine staining during 6 distinct disease phases, and these cells were stimulated with various combinations of cytokines or specific antigens to determine the signaling requirements. Similar studies were performed using SKG mice with arthritis and patients with RA.Results. Gamma/delta T cells were the predomi-

show abstract

Section: Discussionmentioning

confidence: 92%

Gamma/delta T cells are the predominant source of interleukin‐17 in affected joints in collagen‐induced arthritis, but not in rheumatoid arthritis

Ito

Usui

Kobayashi

et al. 2009

Arthritis & Rheumatism

148

125

View full text Add to dashboard Cite

show abstract

“…Interactions of CCL20 and its receptor CCR6, expressed in colorectal cancer, may play a role in development of metastasis by promoting cancer cell proliferation and migration (27,28) and increased expression of CCL20 has been reported in livers of patients with CRLM (29). These studies, however, did not address the effect of preoperative chemotherapy on this system.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans

Rubbia‐Brandt

Tauzin

Brézault

et al. 2011

Molecular Cancer Therapeutics

View full text Add to dashboard Cite

Sinusoidal obstruction syndrome (SOS; formerly veno-occlusive disease) is a well-established complication of hematopoietic stem cell transplantation, pyrrolizidine alkaloid intoxication, and widely used chemotherapeutic agents such as oxaliplatin. It is associated with substantial morbidity and mortality. Pathogenesis of SOS in humans is poorly understood. To explore its molecular mechanisms, we used Affymetrix U133 Plus 2.0 microarrays to investigate the gene expression profile of 11 human livers with oxaliplatin-related SOS and compared it to 12 matched controls. Hierarchical clustering analysis showed that profiles from SOS and controls formed distinct clusters. To identify functional networks and gene ontologies, data were analyzed by the Ingenuity Pathway Analysis Tool. A total of 913 genes were differentially expressed in SOS: 613 being upregulated and 300 downregulated. Reverse transcriptase-PCR results showed excellent concordance with microarray data. Pathway analysis showed major gene upregulation in six pathways in SOS compared with controls: acute phase response (notably interleukin 6), coagulation system (Serpine1, THBD, and VWF), hepatic fibrosis/hepatic stellate cell activation (COL3a1, COL3a2, PDGF-A, TIMP1, and MMP2), and oxidative stress. Angiogenic factors (VEGF-C) and hypoxic factors (HIF1A) were upregulated. The most significant increase was seen in CCL20 mRNA. In conclusion, oxaliplatin-related SOS can be readily distinguished according to morphologic characteristics but also by a molecular signature. Global gene analysis provides new insights into mechanisms underlying chemotherapy-related hepatotoxicity in humans and potential targets relating to its diagnosis, prevention, and treatment. Activation of VEGF and coagulation (vWF) pathways could partially explain at a molecular level the clinical observations that bevacizumab and aspirin have a preventive effect in SOS.

show abstract

“…qRT-PCR data was significant for all 12 genes with fold change values approximating the microarray data. Among these genes, CCL20 together with its unique receptor may contribute to aspects of tumor cell growth and invasion through autocrine and paracrine mechanisms (Schutyser et al, 2003). In addition, concentrations of CXCL5 in peritoneal fluid are markedly elevated in the endometriosis patients, as compared with the controls, especially in women with severe endometriosis, whereas KLRC2 is associated with an increased susceptibility to cancer (Miyashita et al, 2004;Suzumori et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling

et al. 2006

View full text Add to dashboard Cite

The CC chemokine CCL20 and its receptor CCR6

Cited by 682 publications

References 133 publications

Gamma/delta T cells are the predominant source of interleukin‐17 in affected joints in collagen‐induced arthritis, but not in rheumatoid arthritis

Gamma/delta T cells are the predominant source of interleukin‐17 in affected joints in collagen‐induced arthritis, but not in rheumatoid arthritis

Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans

Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling

Contact Info

Product

Resources

About