The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population

Mehri, Sounira; Mahjoub, S.; Finsterer, Josef; Zaroui, Amira; Mechmèche, Rachid; Baudin, Bruno; Hammami, Mohamed

doi:10.1177/1470320310391833

Cited by 14 publications

(14 citation statements)

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“…Gene polymorphism in AT1R with transversion of an adenine (A) to cytosine (C) at 1166 [23]–[24] is associated with cardiovascular diseases such as, coronary artery disease [42], myocardial infarction [43] and essential hypertension [24], [26]–[31]. To our knowledge, the present study is first of its kind, to determine the polymorphism, gene and protein expression of angiotensin II type 1 receptor in Northern Indian population.…”

Section: Discussionmentioning

confidence: 89%

Association of Angiotensin II Type 1 Receptor (A1166C) Gene Polymorphism and Its Increased Expression in Essential Hypertension: A Case-Control Study

et al. 2014

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ObjectivesHypertension is one of the major cardiovascular diseases. It affects nearly 1.56 billion people worldwide. The present study is about a particular genetic polymorphism (A1166C), gene expression and protein expression of the angiotensin II type I receptor (AT1R) (SNP ID: rs5186) and its association with essential hypertension in a Northern Indian population.MethodsWe analyzed the A1166C polymorphism and expression of AT1R gene in 250 patients with essential hypertension and 250 normal healthy controls.ResultsA significant association was found in the AT1R genotypes (AC+CC) with essential hypertension (χ2 = 22.48, p = 0.0001). Individuals with CC genotypes were at 2.4 times higher odds (p = 0.0001) to develop essential hypertension than individuals with AC and AA genotypes. The statistically significant intergenotypic variation in the systolic blood pressure was found higher in the patients with CC (169.4±36.3 mmHg) as compared to that of AA (143.5±28.1 mmHg) and AC (153.9±30.5 mmHg) genotypes (p = 0.0001). We found a significant difference in the average delta-CT value (p = 0.0001) wherein an upregulated gene expression (approximately 16 fold) was observed in case of patients as compared to controls. Furthermore, higher expression of AT1R gene was observed in patients with CC genotype than with AC and AA genotypes. A significant difference (p = 0.0001) in the protein expression of angiotensin II Type 1 receptor was also observed in the plasma of patients (1.49±0.27) as compared to controls (0.80±0.24).ConclusionOur findings suggest that C allele of A1166C polymorphism in the angiotensin II type 1 receptor gene is associated with essential hypertension and its upregulation could play an important role in essential hypertension.

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Section: Discussionmentioning

confidence: 89%

Association of Angiotensin II Type 1 Receptor (A1166C) Gene Polymorphism and Its Increased Expression in Essential Hypertension: A Case-Control Study

et al. 2014

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“…Ten repo The frequency of the C allele in some studies 29,31,32,35 was very low compared to that in other included studies, and those studies were excluded from our further metaanalysis. The frequency of C allele in the case group of the study from Mehri et al 34 was much higher than that in the control group (41.1% vs 29.33%), and this study was also excluded from our further meta-analysis. We re-ran the meta-analysis and found that the pooled OR for the C allele was favorable to the case group, although the difference was not statistically significant (OR=1.09, 95% CI: 0.99-1.19, p=0.07).…”

Section: Discussionmentioning

confidence: 99%

“…The data of interest were extracted: first author's surname, year of publication and the number of cases and controls for AT1R A1166C genotypes (Table 1). Those 18 investigations 18-35 contained 6794 cases and 6204 controls, including 11 studies of Caucasians, [18][19][20][21][22][23][24][25][26][27][28] three studies of Asians, 29,30,35 two studies of Africans, 31,34 one study in the population of Durban in South Africa, 32 and one study in the Brazilian population. 33 The average frequency of C allele distribution in patients with MI for overall populations was 24.74% and the average frequency in controls was 22.58%.…”

Section: Study Characteristics For MImentioning

confidence: 99%

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Zheng

Shi

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Background and aim: Many reported studies have been conducted to investigate the association of angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism with myocardial infarction (MI) susceptibility. However, the results from those reports are still conflicting. This meta-analysis was performed to study the relationship between AT1R A1166C gene polymorphism and MI risk. Method: The databases of PubMed, Embase, and Cochrane Library were searched as of 1 March 2012, and eligible investigations were recruited into this meta-analysis. Results: Eighteen investigations were identified for the analysis of association between AT1R A1166C gene polymorphism and MI risk, 11 in Caucasians, three in Asians, two in Africans, one in the population of Brazil and one in the population of Durban, South Africa . There was a marked association between AT1R C allele and MI susceptibility for overall populations (odds ratio (OR)=1.12, 95% confidence interval (CI): 1.01-1.25, p=0.03), and AT1R AA genotype was associated with a lower risk of MI in overall populations (OR=0.87, 95% CI: 0.78-0.98, p=0.02). However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations. Conclusions: C allele is a risk factor for the MI susceptibility in overall populations, and AA genotype might be a protective factor against the MI risk in overall populations. However, more case-control association investigations on larger, stratified populations are required in the future.

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“…CAD is a multifactorial disease triggered by environmental as well as genetic factors [3]. Not only smoking, diabetes mellitus, obesity, hypertension, and low-density lipoprotein (LDL) increases the risk of CAD, but also genetic susceptibility plays a role.…”

Section: Introductionmentioning

confidence: 99%

Risk Assessment Using the Association Between Renin-Angiotensin Genes Polymorphisms and Coronary Artery Disease

Riad¹,

Adhikari²,

Bhattarai³

et al. 2021

Cureus

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Coronary artery disease (CAD) is a multifactorial disease that involves genetic and environmental interaction. In addition to the well-known CAD risk factors, such as diabetes mellitus, hypertension, hyperlipidemia, and atherosclerosis, it has a genetic component that predisposes to its occurrence even in young people. One of the most commonly studied genes that increase the susceptibility to CAD is reninangiotensin system (RAS) genes polymorphisms mainly angiotensin-converting enzyme gene (ACE) polymorphisms, angiotensinogen polymorphisms, angiotensin-II type 1 receptor gene polymorphisms, and many other genes. These genetic polymorphisms have a direct association with CAD development or indirect association through causing atherosclerosis and hypertension which, in turn, are complicated by CAD later on. The difference between genetic mutations and polymorphisms lies in the frequency of the abnormal genotype. If the frequency is 1% and more in the general population, it is called polymorphism and if it is less than 1%, then it is called a mutation.According to our findings, after thorough searching, which support the association of RAS genes polymorphisms with premature CAD, hypertension, hypertrophic cardiomyopathy, and atherosclerosis, we recommend additional studies in the form of clinical trials and meta-analyses aiming to create a specific diagnostic tool for CAD risk assessment and discovering the high-risk people as early as possible. Targeted gene therapy, being the future of medicine, needs to be taken into researchers' consideration. It can have promising results in these cases.Categories: Cardiology, Genetics Keywords: ace polymorphism and myocardial infarction, ras polymorphism and coronary artery disease, ras polymorphism and hypertension, enos polymorphism and coronary artery disease 1 1, 2 3 3 3 1 4 Open Access Review Article

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The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population

Cited by 14 publications

References 25 publications

Association of Angiotensin II Type 1 Receptor (A1166C) Gene Polymorphism and Its Increased Expression in Essential Hypertension: A Case-Control Study

Association of Angiotensin II Type 1 Receptor (A1166C) Gene Polymorphism and Its Increased Expression in Essential Hypertension: A Case-Control Study

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Risk Assessment Using the Association Between Renin-Angiotensin Genes Polymorphisms and Coronary Artery Disease

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