The CCHC-type zinc finger ZCCHC18 is differentially expressed in high-grade serous ovarian cancers.

Abstract

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We identified the zinc finger CCHC-type containing 18 (ZCCHC18) as among the genes whose expression was most different in HGSC ovarian tumors. ZCCHC18 expression was significantly lower in ovarian tumors relative to normal ovary. These data indicate that significant loss of ZCCHC18 expression could be a feature of high-grade serous ovarian cancers.