The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions

Clark, Georgina J.; Ju, Xinsheng; Tate, Courtney; Hart, Derek N.J.

doi:10.1016/j.it.2009.02.003

Cited by 105 publications

(150 citation statements)

References 58 publications

Supporting

Mentioning

148

Contrasting

Order By: Relevance

“…The expression levels of CD300ld and CD300lf in RAW264.7 cells are considered low and absent, respectively, based on transcriptional analyses (21). The ectopic CD300lf expression on the HEK293T cell surface appeared to be higher than that on the RAW264.7 cell surface based on the fluorescent signals of CD300lf expression (Figs.…”

Section: Discussionmentioning

confidence: 99%

Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells

Haga

Fujimoto

Takai‐Todaka

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

160

154

View full text Add to dashboard Cite

Norovirus is the leading cause of acute gastroenteritis worldwide. Since the discovery of human norovirus (HuNoV), an efficient and reproducible norovirus replication system has not been established in cultured cells. Although limited amounts of virus particles can be produced when the HuNoV genome is directly transfected into cells, the HuNoV cycle of infection has not been successfully reproduced in any currently available cell-culture system. Those results imply that the identification of a functional cell-surface receptor for norovirus might be the key to establishing a norovirus culture system. Using a genome-wide CRISPR/Cas9 guide RNA library, we identified murine CD300lf and CD300ld as functional receptors for murine norovirus (MNV). The treatment of susceptible cells with polyclonal antibody against CD300lf significantly reduced the production of viral progeny. Additionally, ectopic CD300lf expression in nonsusceptible cell lines derived from other animal species enabled MNV infection and progeny production, suggesting that CD300lf has potential for dictating MNV host tropism. Furthermore, CD300ld, which has an amino acid sequence in the N-terminal region of its extracellular domain that is highly homologous to that of CD300lf, also functions as a receptor for MNV. Our results indicate that direct interaction of MNV with two cell-surface molecules, CD300lf and CD300ld, dictates permissive noroviral infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells

Haga

Fujimoto

Takai‐Todaka

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

160

154

View full text Add to dashboard Cite

show abstract

“…For instance, Moshkovits et al did not detect CD300f expression on colonic macrophages or mast cells, and they failed to examine CD300f expression on DCs (34), whereas we detect CD300f expression on macrophages, DCs, neutrophils, and mast cells in colonic lamina propria (Supplemental Figure 11); similarly, Matsukawa et al (20) readily detected CD300f on the surface of colonic mast cells, macrophages, and eosinophils. The lack of detection of CD300f on lamina propria macrophages by Moshkovits and colleagues is surprising, as, in general, macrophages could be considered a hallmark of CD300f expression (18,(35)(36)(37). CD300f expression has been shown to be regulated by various cytokines (38,39), which could depend on exposure to environmental factors and/ or different microbiota communities present in the animal facilities.…”

Section: Cd300fmentioning

confidence: 99%

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Lee¹,

Tian²,

Bouladoux³

et al. 2017

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…30 The human CD300 receptors are type I transmembrane proteins with single IgV-like extracellular domains that are mainly expressed by myeloid cells. [31][32][33] The orthologous mouse family has a variety of names, including CMRF-like molecules (CLM), 31,32,34 but for simplicity in this report we use the human nomenclature for both species. Mouse CD300f (CLM-1) possesses both activating and inhibitory signaling potentials for regulation of AC engulfment upon PS recognition.…”

mentioning

confidence: 99%

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Tian

Lee

et al. 2016

Cell Death Differ

View full text Add to dashboard Cite

Homeostasis requires the immunologically silent clearance of apoptotic cells before they become pro-inflammatory necrotic cells. CD300f (CLM-1) is a phosphatidylserine receptor known to positively regulate efferocytosis by macrophages, and CD300f genedeficient mice are predisposed to develop a lupus-like disease. Here we show that, in contrast to CD300f function in macrophages, its expression inhibits efferocytosis by DC, and its deficiency leads to enhanced antigen processing and T-cell priming by these DC. The consequences are the expansion of memory T cells and increased ANA levels in aged CD300f-deficient mice, which predispose CD300f-deficient mice to develop an overt autoimmune disease when exposed to an overload of apoptotic cells, or an exacerbated autoimmunity when combined with FcγRIIB deficiency. Thus, our data demonstrates that CD300f helps to maintain immune homeostasis by promoting macrophage clearance of self-antigens, while conversely inhibiting DC uptake and presentation of self-antigens.

show abstract

The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions

Cited by 105 publications

References 58 publications

Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells

Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Contact Info

Product

Resources

About