The CD4/CD8 ratio is associated with coronary artery disease (CAD) in elderly Chinese patients

Gao, Pan; Rong, Honghui; Lu, Tong; Tang, Gang; Si, Liang-Yi; Lederer, James A.; Xiong, Wei

doi:10.1016/j.intimp.2016.11.007

Cited by 11 publications

(10 citation statements)

References 28 publications

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“…50 In a recent study, CD4 cells and CD8 cells in peripheral blood were measured in individuals aged >60 years who had been diagnosed with atherosclerotic CAD with >50% obstructive plaques in the coronary arteries. 43 The CD4/CD8 ratio was found to be independently higher in the CAD group as compared with the non-CAD group after adjusting for classical risk factors. 43 In another crosssectional study, a peripheral blood expansion of CD8 + T cells was observed in CAD patients, and more extensively in patients <60 years with unstable angina.…”

Section: Peripheral Blood Circulating T-cell Level In Cadmentioning

confidence: 85%

“…43 The CD4/CD8 ratio was found to be independently higher in the CAD group as compared with the non-CAD group after adjusting for classical risk factors. 43 In another crosssectional study, a peripheral blood expansion of CD8 + T cells was observed in CAD patients, and more extensively in patients <60 years with unstable angina. 19 Thus, a role of T cells in >50% obstructive plaques has been observed in a wide age range of individuals with significant atherosclerosis without MI.…”

Section: Peripheral Blood Circulating T-cell Level In Cadmentioning

confidence: 85%

“…55 Thus, in over, on evaluation of the feasibility of immune cells as a diagnostic tool, these circulating T cells, their subtypes and their ratio were found to hold promise as biomarkers of coronary artery disease ( Table 2). 8,9,18,19,24,26,28,29,[35][36][37][38][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] Peripheral measurements of T-cell subsets and their levels in ACVD patients are summarized in Table 2.…”

Section: Acquired Immunodeficiency Promotes Cvdmentioning

confidence: 99%

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Immune Disorder in Atherosclerotic Cardiovascular Disease　― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―

Neupane

Jin

Sasaki

et al. 2019

Circ J

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receptors and secrete IL-2, a mechanism that facilitates preferential expansion of antigen-specific T cells. 4 Recent research further elaborated the role of adaptive immune responses in atherosclerotic phenomena, and a more precise examination of atherosclerotic plaques showed the presence of T-lymphocyte subset cluster differentiation (CD) 4 and CD8 T cells. 5 Status of Immune Disorder and Atherosclerotic Cardiovascular Disease Research History of the Immune System The immune system is the complex defense system of the body. Its main function is to distinguish between selfmolecules (antigens) in the body and non-self-antigens such as bacteria, viruses, and fungi, as well as damaged tissue in the body. The immune system consists of various types of cells and soluble molecules such as complement factors and cytokines. 6 The immune system is classified into innate immunity and adaptive immunity (Figure 2). We have also summarized the development of T cells and their subsets (Figure 2; Table 1). 7-20

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Section: Peripheral Blood Circulating T-cell Level In Cadmentioning

confidence: 85%

Section: Peripheral Blood Circulating T-cell Level In Cadmentioning

confidence: 85%

Section: Acquired Immunodeficiency Promotes Cvdmentioning

confidence: 99%

See 1 more Smart Citation

Immune Disorder in Atherosclerotic Cardiovascular Disease　― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―

Neupane

Jin

Sasaki

et al. 2019

Circ J

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“…Significant difference between these patients and outpatients, so as control group, was confirmed with ANOVA test. CD4/CD8 ratio is very important in follow-up of some viral diseases and other medical conditions (12, 13). We found significant decrease in values of CD4/CD8 in hospitalized patients, while values in group of outpatients and controls were almost the same.…”

Section: Discussionmentioning

confidence: 99%

T-lymphocyte Subsets as a Prognostic Factor in a Clinical Course of Chickenpox

et al. 2017

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Objective:To investigate possible prognostic values of CD4+, CD8+ T-lymphocytes, CD4/CD8 ratio to clinical course of chickenpox in immunocompetent hosts.Materials and methods:We performed a prospective study which included 69 immunocompetent patients with chickenpox who were addmited to Clinic for infectious disease, Clinical Center University of Sarajevo, in a 18 month period. All patients were divided into two groups depending on clinical presentation on admission. Patients with mild clinical form were dedicated to „outpatient” group, and patients with moderate, severe or life-threatening clinical forms were dedicated to „hospitalized” group. Also 30 healthy volunteers are included in study as a control group. We analyzed values of CD4+, CD8+ percentage, CD4/CD8 ratio with comparison to clinical course of chickenpox. All specimens were taken in acute phase of illness.Results:Values of CD4+ percentage were significantly declined in a group of hospitalized patients, compared to group of outpatients and control group. Values of CD8+ percentage were higher in a group of hospitalized patients, while CD4/CD8 values were lower in comparison to a group of outpatients and control group.Conclusion:We found significant correlation between these parameters and clinical course of chickenpox.

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“…Endocrine endothelial function, which consists in the synthesis and secretion of NO and PGI, is a prerequisite for the preservation of its integrity and correct relationship between Currently, there is no doubt that atherosclerosis is a chronic inflammatory disease involving many immunological processes. Some researchers of these medical conditions compare them with other chronic inflammatory disorders, in which immune and autoimmune reactions play an important role [40,41].…”

Section: Vulnerable Plaquementioning

confidence: 99%

Atherothrombosis as a Leading Cause of Acute Coronary Syndromes and Stroke: The Main Killers in Developed Countries

Dziedzic¹,

Machowski²,

Oleszczak-Kostyra³

et al. 2018

Atherosclerosis - Yesterday, Today and Tomorrow

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Worldwide, cardiovascular incidents are estimated to cause 17.5 million deaths, 80% of which are ischemic strokes or acute coronary syndromes. Cardiovascular disease results in a significant financial burden for healthcare system-namely, in 2009, it was 9% of the gross health service expenditure in the European Union. Therefore, the development of the knowledge about atherosclerosis-initially thought to be solely degenerative disorder but now considered a multifactorial inflammatory state-is essential. Acute coronary syndrome (ACS) is usually a manifestation of severe reduction in coronary blood flow caused by atherosclerotic plaque and thrombus. The pathology of the atherosclerotic plaque is complex. Essentially, it is disease of the arterial intima that, through subsequent stages, results to luminal narrowing. Over the years, various theories regarding the genesis growth and vulnerability of atherosclerotic lesions have been promoted, usually focusing on endothelial injury, smooth muscle cell proliferation, lipid accumulation, and, more recently, inflammatory reactions.

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The CD4/CD8 ratio is associated with coronary artery disease (CAD) in elderly Chinese patients

Cited by 11 publications

References 28 publications

Immune Disorder in Atherosclerotic Cardiovascular Disease　― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―

Immune Disorder in Atherosclerotic Cardiovascular Disease　― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―

T-lymphocyte Subsets as a Prognostic Factor in a Clinical Course of Chickenpox

Atherothrombosis as a Leading Cause of Acute Coronary Syndromes and Stroke: The Main Killers in Developed Countries

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The CD4/CD8 ratio is associated with coronary artery disease (CAD) in elderly Chinese patients

Cited by 11 publications

References 28 publications

Immune Disorder in Atherosclerotic Cardiovascular Disease ― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―

Immune Disorder in Atherosclerotic Cardiovascular Disease ― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―

T-lymphocyte Subsets as a Prognostic Factor in a Clinical Course of Chickenpox

Atherothrombosis as a Leading Cause of Acute Coronary Syndromes and Stroke: The Main Killers in Developed Countries

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Product

Resources

About

Immune Disorder in Atherosclerotic Cardiovascular Disease　― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―

Immune Disorder in Atherosclerotic Cardiovascular Disease　― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ―