Purpose
Early identification of colorectal cancer (CRC) is an international priority.
Multimorbidity (presence of ≥2 long-term conditions (LTCs)) is increasing
and the relationship between CRC and LTCs is little-understood. This study
explores the relationship between individual LTCs, multimorbidity and CRC
incidence and mortality.
Methods
Longitudinal analysis of the UK Biobank cohort, participants recruited
2006–2010;
N
= 500,195; excluding previous CRC at baseline.
Baseline data was linked with cancer/mortality registers. Demographic
characteristics, lifestyle factors, 43 LTCs, CRC family history, non-CRC
cancers, and multimorbidity count were recorded. Variable selection models
identified candidate LTCs potentially predictive of CRC outcomes and Cox
regression models tested for significance of associations between selected
LTCs and outcomes.
Results
Participants’ age range: 37–73 (mean age 56.5; 54.5% female). CRC was
diagnosed in 3669 (0.73%) participants, and 916 (0.18%) died from CRC during
follow-up (median follow-up 7 years). CRC incidence was higher in the
presence of heart failure (Hazard Ratio (HR) 1.96, 95% Confidence Interval
(CI) 1.13–3.40), diabetes (HR 1.15, CI 1.01–1.32), glaucoma (HR 1.36, CI
1.06–1.74), male cancers (HR 1.44, CI 1.01–2.08). CRC mortality was higher
in presence of epilepsy (HR 1.83, CI 1.03–3.26), diabetes (HR 1.32, CI
1.02–1.72), osteoporosis (HR 1.67, CI 1.12–2.58). No significant association
was found between multimorbidity (≥2 LTCs) and CRC outcomes.
Conclusions
The associations of certain LTCs with CRC incidence and mortality has
implications for clinical practice: presence of certain LTCs in patients
presenting with CRC symptoms could trigger early investigation and
diagnosis. Future research should explore causative mechanisms and patient
perspectives.