The cell cycle and related concepts in cell proliferation

Influence of endostatin on embryonic vasculo‐ and angiogenesis

“…To exclude that this effect was due to increased proliferation instead of migration, we chose a migration time of 8 hr. This strategy excluded proliferation as a potential mechanism, because the minimum cell division time averaged 10 to 38 hr (Edmunds and Adams, 1981;Gallwitz, 1981;Smith, 1982). The increased rate of migration was also observed when using MACS-sorted embryonic stem cell-derived endo-…”

Cell proliferation in gastrointestinal mucosa.

“…It has been suggested that in late G 1 , genetically controlled event triggers the initiation of DNA synthesis, sometimes referred to as a transition probability event; the probability of passing through this transition is high in the gut, and thus the cells cycle rapidly. 1 In the gastrointestinal system, cells eventually leave the cell cycle and diVerentiate, but in some tissues they may enter a resting phase, known as G 0 , although there is little evidence of a G 0 phase in the gut. DiVerentiated cells are generally believed to lose their proliferative capacity, but in extreme conditions, they can be persuaded to enter the cell cycle again by expression of, for example, SV40T antigen.…”

METTL3 promotes cell cycle progression via m6A/YTHDF1-dependent regulation of CDC25B translation

“…As a ubiquitous and complex process, the cell cycle is the core event that regulates cell proliferation, and it is closely related to carcinogenesis 1 , 2 . The cell cycle includes DNA synthesis (S) and mitosis (M) phases, which are separated by a gap phase; the phases progress in the order G1-S-G2-M.…”