The Cell Surface

Berlin, Richard D.; Oliver, James M.; Ukena, Thomas E.; Yin, H. H.

doi:10.1056/nejm197503062921007

Cited by 54 publications

(10 citation statements)

References 14 publications

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“…A recent review of the cell surface suggests that the topography of membrane proteins can be modified by exposure of cells to various substances (2). Viral replication dependent upon budding from the cytoplasmic membrane might VOL.…”

Section: Resultsmentioning

confidence: 99%

Vaccinia virus meningitis in mice after intracerebral inoculation

Ginsberg¹,

Johnson²

1976

Infect Immun

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The pathogenesis of experimental vaccinia virus infection in weanling mice after intracerebral inoculation was followed with virological, histological, and immunohistological methods. High-dose inoculation, virus spread from brain to thoracic and abdominal viscera probably by an undetected early viremia. Virus did rise to detectable levels in blood by day 5 and was found to be associated with the mononuclear cell fraction. By day 12, 30% of the animals had died and no further deaths occurred. Rise of neutralizing antibody correlated with disappearance of cell-free virus in blood, brain, and viscera. Virus was present in the brains of animals for 20 days after inoculation. This animal model may be useful to study mechanisms of persistent central nervous system virus disease relevant to man.

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Section: Resultsmentioning

confidence: 99%

Vaccinia virus meningitis in mice after intracerebral inoculation

Ginsberg¹,

Johnson²

1976

Infect Immun

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“…The only other example in the literature of a case where there is evidence that selective segregation of membrane proteins may occur is in phagocytizing leukocytes. Work by Berlin and associates (5,28) suggests that certain membrane proteins (transport systems) are selectively retained in the plasma membrane at the cell surface and that others (Con A receptors) are selectively removed and segregated in the membrane of the invaginating phagocytic vacuole, Recent findings suggest that the integral or intrinsic membrane sialoglycoproteins of the human erythrocyte, glycophorin and Band III, form an intramembrane macromolecular complex (14,25,30) which spans the membrane and interacts with extrinsic inner membrane surface proteins such as spectrin (6,26,41,44) or actin (14,39). Due to such an interaction, it might be expected that migration by lateral diffusion of sialoproteins in the erythrocyte membrane would be determined by their association with these extrinsic membrane proteins.…”

Section: Discussionmentioning

confidence: 99%

Variations in distribution of con A receptor sites and anionic groups during red blood cell differentiation in the rat.

Skutelsky¹,

Farquhar²

1976

The Journal of Cell Biology

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The distribution of receptors for concanavalin A (Con A) and anionic groups on plasma membranes of developing blood cells was investigated in the rat. Glutaraldehyde-fixed bone marrow and circulating blood cells were exposed to ferritinconjugated Con A or positively charged ferric oxide (CI) and processed for electron microscopy. The frequency of Con A and CI binding sites varied during different erythroid developmental stages and among different Jeukoid cell types. There was a constant inverse relationship between Con A and CI binding sites. Among leukoid cells, Con A binding was high on plasma cells and macrophages, lower on neutrophils and lymphocytes, and still lower on eosinophils and basophils; CI binding was highest in the latter and lowest in plasma cells and macrophages. Among erythroid cells, there was a progressive increase in Con A and a decrease in CI binding after successive divisions of erythroblasts, and a progressive decrease in Con A and an increase in CI binding upon maturation of the orthochromatic erythroblast to the reticulocyte. The most pronounced modification in distribution of these sites occurred during nuclear expulsion: that portion of the plasma membrane surrounding the extruded nucleus was heavily labeled by Con A (up to four times that of the orthochromatic erythroblast) whereas the reticulocyte had considerably fewer sites. The situation was reversed with CI. The results suggest that the concentration of nonsialated glycoproteins (to which Con A binds) varies inversely to that of sialoproteins (to which CI binds) in the membrane of the differentiating erythroid cell. The remarkable changes observed at the time of nuclear extrusion suggest that there is either local modification of glycosylated groups with removal of sialyl residues from the membrane surrounding the extruded nucleus or selective segregation of membrane glycoproteins leading to a high concentration of sialoproteins (glycophorin) in the membrane of the mature erythrocyte.Previous studies utilizing electron microscope labeling techniques have established that differentiation of the mammalian erythrocyte is associated with significant changes in the density and distribution of binding sites (presumably glycoproteins) on the plasma membrane. Differences have been

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“…At the same time, the adherence of the lymphocyte tail to the substrate-fixed complementary receptors is reported to slow down or completely inhibit cell translocation for periods of varying length. Tumour cell invasion seems to presuppose active locomotion without adequate control mechanisms ( I , 3,8).…”

Section: Discussionmentioning

confidence: 99%

Amoeboid Movement Configuration in Tumour Cells of Bone Marrow Smears from Patients with Leukaemia

Sjögren

Norberg

Rydgren

1977

Journal of Internal Medicine

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The incidence of amoeboid movement configuration (AMC), a cell shape suggestive of cell locomotion at the moment of fixation, has been studied in the tumour cells of bone marrow smears from leukaemia patients at the time of diagnosis. The groups of patients with CML (n=8), ALL (n=5) and CLL (n=9) were small, and the incidences of AMC were close to those found in the corresponding cell lines from healthy probands. In 39 patients with AML, the incidence of AMC was higher than in the other cell lines investigated. A positive skew distribution of AMC values and a positive significant correlation between incidence of AMC were found at the time of diagnosis and subsequent survival of the patients with AML, in spite of differences in treatment. It is suggested that this positive correlation may be due to an immune reaction of the patients against their tumour cells.

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The Cell Surface

Cited by 54 publications

References 14 publications

Vaccinia virus meningitis in mice after intracerebral inoculation

Vaccinia virus meningitis in mice after intracerebral inoculation

Variations in distribution of con A receptor sites and anionic groups during red blood cell differentiation in the rat.

Amoeboid Movement Configuration in Tumour Cells of Bone Marrow Smears from Patients with Leukaemia

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