The cellular origin of multiple monoclonal immunoglobulins reflects the postulated pathways of isotype differentiation of antibody-forming cells

Krueger, Robert G.; Hilton, Pamela M.; Boehlecke, Jeanne M.; Kyle, Robert A.; Fair, Daryl S.

doi:10.1016/0008-8749(80)90220-8

Cited by 5 publications

(1 citation statement)

References 52 publications

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“…Since 1978, when Fair and Krueger (1) reviewed all 10 cases reported up to then, fewer than 10 new cases have been discovered Three M-components present in the serum of an individual are usually characterized as having different heavy chain isotypes (2, 9, 10, ll), the same type of light chains (3,4,9,11,12) and crossreacting idiotypic determinants (3,4,10,(12)(13)(14). All these characteristics led to the general acceptance that these monoclonal immunoglobulins are the products of the same original B-cell clone (2, 3, 12, 13, 14,15).…”

Section: Introductionmentioning

confidence: 99%

Three monoclonal IgG components, an IgG4(Λ), an IgG2(κ) and an IgG1/IgG3 (κ) Gm(f,b) hybrid, in a single myeloma patient

Milosević-Jovcić

Dovezenski

Jovanović

et al. 1995

European J of Haematology

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An unusual triclonal IgG combination in the serum of a 56‐year old male with clinical stage IIIB multiple myeloma is reported. The patient initially had an IgG4(Λ) monoclonal protein in his serum and later developed an IgG2(κ) and an IgG (κ) which possessed the characteristics of both IgG1 and IgG3 subclasses with an unusual combination of allotypic markers. Three M‐proteins did not share idiotypic determinants. A rare class‐switch recombination followed by mutation has been considered as a possible mechanism leading to this combination.

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Section: Introductionmentioning

confidence: 99%