The cellular reproduction in physiological and reparative liver regeneration

Geisler, A.; Stiller, K.J.; Machnik, G

doi:10.1016/s0940-2993(11)80093-x

Cited by 7 publications

(7 citation statements)

References 6 publications

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“…Zonal differences in hepatocellular proliferation were already reported in rats and mice for several compounds such as Wy-14,643, which stimulates cell proliferation predominantly in zone 1 (Eacho et al, 1991;Marsman et al, 1988;Wada et al, 1992), ethinyl-estradiol in zone 2 (Mayol et al, 1992;Stephan, 2001), and phenobarbital in zone 3 (Kolaja et al, 1996;Schulte-Hermann et al, 1986). In livers of control rats, cell proliferation is highest in the periportal area and decreases towards the draining vein (Geisler et al, 1994;Heuser, 2000;Stephan, 2001;Werlich et al, 1998;Zaijcek et al, 1985). Since mice, as rodents, are phylogenetically closely related to rats, tremendous differences are not assumed; both species, however, vary to some degree in liver morphology and sometimes show significant differences in compound-related effects.…”

Section: Introductionmentioning

confidence: 83%

“…In livers of control rats, cell proliferation is highest in the periportal area and decreases towards the draining vein (Geisler et al, 1994;Heuser, 2000;Stephan, 2001;Werlich et al, 1998;Zaijcek et al, 1985). Since mice, as rodents, are phylogenetically closely related to rats, tremendous differences are not assumed; both species, however, vary to some degree in liver morphology and sometimes show significant differences in compound-related effects.…”

Section: Introductionmentioning

confidence: 99%

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Zonal Distribution of Cell Proliferation in the Liver of Untreated B6C3F1 and C57BL Mice

et al. 2004

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To determine the lobular distribution of hepatocellular proliferation, S-phase response was measured in untreated adult male B6C3F1 and C57BL mice at ages 11, 14, and 23 weeks. The percentage of cells in S-phase (labeling index, LI) was evaluated using immunohistochemical detection of 5-bromo-2 -deoxyuridine (BrdU). The BrdU was delivered either by a single ip injection 2 hr prior to sacrifice or via an osmotic minipump implanted subcutaneously for 3 or 7 days. Mitotic and apoptotic indices were determined on H&E stained sections. Animals of both strains and all ages revealed highest LI in the intermediate compartment of the liver acinus (zone 2) irrespective of the length of BrdU application. Cell proliferation in this zone was at all time points significantly higher than elsewhere in the liver. The mitotic index confirmed the data obtained by the S-phase response study. Apoptosis was rarely observed. With regard to rodent data in chemical carcinogenesis and the way they should be evaluated, this study proved that the acinar distribution of proliferating cells in liver of mice is different from that in rats, since, according to the literature, rats reveal highest cell proliferative activity in the periportal zone.

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Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Zonal Distribution of Cell Proliferation in the Liver of Untreated B6C3F1 and C57BL Mice

et al. 2004

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“…Furthermore, we recently reported that a cell line established from one of the mouse HBs obtained in the present study required hepatocyte growth factor for optimal growth and expressed c-met, a protooncogene encoding the hepatocyte growth factor receptor, suggesting mouse HB can possibly originated from an early stage of hepatocellular tumor because of the lack of autonomous growth [14]. Though the existence of hepatic stem cells is still controversial [8,23,28,30,31], the present results illustrate a possibility of multidirectional differentiating potential in mouse HB cells. As recently speculated for human HBs [26], furthermore, mouse HB cells may provide a potential of endodermal cells or play roles, less committed, as even stem cells [24].…”

Section: Discussionmentioning

confidence: 58%

Immunohistochemical Characterization of Hepatoblastomas in B6C3F1 Mice Treated with Diethylnitrosamine and Sodium Phenobarbital.

Sakairi¹,

Kobayashi²,

Goto³

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. Hepatoblastomas (HBs) were induced in B6C3F1 male mice by diethylnitrosamine (DEN) and sodium phenobarbital (PB). Six-week-old mice received a single intraperitoneal dose of DEN followed by a continuous treatment with PB in diet at a concentration of 0 (group 1) or 500 (group 2) ppm for 50 weeks. HBs were observed in 13 of 21 (62%) group 2 mice, with typical histologic features as reported previously, while no such tumors were observed in group 1. Seven of 13 (54%) HBs were found in and/or adjacent to hepatocellular adenomas (HCAs) or hepatocellular carcinomas (HCCs). Immunohistochemically, all HBs were positive for S-100 protein but negative for keratin, α-fetoprotein (AFP), albumin (ALB) and vimentin, while HCC cells occasionally reacted positively for AFP with a mosaic pattern. HCC and HCA cells were occasionally positive for ALB. Non-neoplastic hepatocytes and normal bile ducts were positively stained for ALB and keratin/S-100 protein, respectively. S-100 protein is known to be expressed in many mesenchymal tissues and neoplasms including neuroectodermal elements but negative in cells of the hepatic lineage. Thus, the present immunohistochemical results suggested that mesenchymal differentiation occurs in mouse HB cells as observed in human HBs, one of the most frequent infant liver tumors in humans. Although the susceptibility of mouse HBs to PB-promotion suggests a hepatocytic histogenesis, the present immunohistochemical results support the hypothesis that the mouse HB is derived from pluripotent endodermal stem-like cells. KEY WORDS: hepatoblastoma, immunohistochemistry, mouse, S-100 protein.

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“…Кроме того, на фоне неблагоприятной экологической обстановки, хронических стрессов, вредных привычек часто прояв-ляются побочные эффекты препаратов в виде аллерги-ческих реакций, нарушения иммунной реактивности, дисбактериоза, кандидоза и т. д. [4,7,10,11,13]. Всё это обуславливает попытки поиска новых способов и средств лечения, в том числе разработки и применения препаратов растительного происхождения [1].…”

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Clinical Evaluation of Terpene Medicament Effectiveness in a Complex Treatment of Chronic Generalized Parodontitis

Dudar¹,

Молоков²,

Тирская³

et al. 2018

Acta Biomedica Scientifica

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The cellular reproduction in physiological and reparative liver regeneration

Cited by 7 publications

References 6 publications

Zonal Distribution of Cell Proliferation in the Liver of Untreated B6C3F1 and C57BL Mice

Zonal Distribution of Cell Proliferation in the Liver of Untreated B6C3F1 and C57BL Mice

Immunohistochemical Characterization of Hepatoblastomas in B6C3F1 Mice Treated with Diethylnitrosamine and Sodium Phenobarbital.

Clinical Evaluation of Terpene Medicament Effectiveness in a Complex Treatment of Chronic Generalized Parodontitis

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