The Central Dopaminergic System: Susceptibility to Risk Factors for Accelerated Aging

Govoni, Stefano; Rius, R.A.; Battaini, F.; Magnoni, Maria Sandra; Lucchi, Laura; Trabucchi, Marco

doi:10.1159/000212927

Cited by 14 publications

(2 citation statements)

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“…Impairment of swimming ability, which was similar to that seen after electrolesion of the lateral hypothalamus including the nigro-striatal dopaminergic neurons, was observed in aged rats (7). Diminution of synthesis, release and re-uptake of dopamine and decrease in D-2 dopamine receptors in the striatum were reported in aged animals (8)(9)(10)(11).…”

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confidence: 60%

Effect of Panax ginseng on age-related changes in the spontaneous motor activity and dopaminergic nervous system in the rat.

et al. 1991

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-Effectsof Panax ginseng on the spontaneous motor activity and central dopaminergic systems in old rats were investigated and compared with those in young rats. Oral intake of a 1.8% water extract of Panax ginseng for four weeks produced an increase in spontaneous motor activity during the dark period in old rats, while it caused a decrease in the activity in young rats. After the intake of ginseng extract for five weeks, it caused a significantly low dopamine utilization in the daytime in the striatum of old rats, while it produced a high dopamine utilization in the structure of young rats. Concentrations of striatal dopamine D-2 receptors in old rats were significantly lower than that in young rats, although subchronic Panax ginseng did not affect the striatal D-1 and D-2 receptors of old rats. These results suggest that subchronic intake of ginseng extract inhibits the activity of nigro-striatal dopamine neurons in the daytime and activates spontaneous motor activity during the dark period in old rats, while it produces opposite effects in young rats.Panax ginseng root produces various neuropharmacological effects such as changes in brain biogenic amines, improvement of learning and memory retention (1), promotion of recovery from fatigue (ref. A decrease in motor activity was shown in aged mice in association with an increase in monoamine oxidase activity in the brain (6). Impairment of swimming ability, which was similar to that seen after electrolesion of the lateral hypothalamus including the nigro-striatal dopaminergic neurons, was observed in aged rats (7). Diminution of synthesis, release and re-uptake of dopamine and decrease in D-2 dopamine receptors in the striatum were reported in aged animals (8-11).We investigated the effects of a water extract of Panax ginseng root on spontaneous motor activity and nigro-striatal dopaminergic nervous systems in two year-old rats and compared them with those in young rats. MATERIALS AND METHODSYoung and old male Fischer 344 rats (3 and 24 months old at the end of the experiment, respectively; Nippon Charles River, Tokyo) were used. They were kept under an alternat-

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Effect of Panax ginseng on age-related changes in the spontaneous motor activity and dopaminergic nervous system in the rat.

et al. 1991

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“…That DA dysregulation may be especially pertinent to the neurobiology of late-life suicide is suggested by three lines of evidence. First, there are welldocumented reductions in dopaminergic neuron number, the function of receptors and uptake sites, and synthetic enzyme activity with increasing age (DeKeyser et al, 1990;Govoni et al, 1988;Morgan, 1987). Second, suicide risk appears to be elevated in both Parkinson's disease and Huntington's disease-disorders in which degenerative changes of the central dopaminergic system have been implicated (Farrer, 1986;Mayeux, 1990;Schoenfeld et al, 1984); and third, there is mounting evidence that DA dysfunction underlies some affective disorders (Brown & Gershon, 1993), the prevalence of which increases with age at suicide.…”

Section: Dopamine (Da)mentioning

confidence: 99%

Suicide and Aging II: The Psychobiological Interface

Conwell

Raby

Caine

1995

Int. Psychogeriatr.

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There is an accumulating body of research suggesting that suicidal behavior may be associated with abnormalities of the central serotonin system. Other monoaminergic, peptidergic, and neuroendocrine systems have been implicated as well. A review of studies that examine neurobiological variables in postmortem tissue of suicide victims and controls reveals that investigators in most instances have viewed age as a confound to be controlled rather than considering it as a variable of interest. However, the close associations between aging and increased suicide rates, and the knowledge that the functional integrity of many of these same systems changes with normal and abnormal aging processes, raise the possibility that biological aging contributes to suicide risk, and that the underlying neurobiology of suicide in the elderly differs from that of younger people. The few available studies that did examine the association of age with neurobiological measures indicate directions for future research into the role that aging may play in determining the biological bases of suicide risk.

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Prolonged Dietary Restriction and Its Effects on Dopamine Systems of the Brain

Scalzo¹

1992

The Vulnerable Brain and Environmental Risks

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The Central Dopaminergic System: Susceptibility to Risk Factors for Accelerated Aging

Cited by 14 publications

References 10 publications

Effect of Panax ginseng on age-related changes in the spontaneous motor activity and dopaminergic nervous system in the rat.

Effect of Panax ginseng on age-related changes in the spontaneous motor activity and dopaminergic nervous system in the rat.

Suicide and Aging II: The Psychobiological Interface

Prolonged Dietary Restriction and Its Effects on Dopamine Systems of the Brain

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