The Central Nervous System Modulates the Immune Response to Salmonella

Campos-Rodrı́guez, Rafael; Stephano, Andrés Quintanar; Drago-Serrano, María Elisa; Abarca-Rojano, Edgar; Berczi, István; Ventura‐Juárez, Javier; Kormanovski, Alexander

doi:10.5772/29344

Cited by 2 publications

(1 citation statement)

References 156 publications

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“…However present data suggests that this theory may not apply when host is infected with multiple Salmonella serovars. Concentration of corticosterone levels in sera can increase or decrease the antibody response [ 36 ]. In this study the high corticosterone levels did not suppress the humoral immune response against Salmonella Typhimurium.…”

Section: Discussionmentioning

confidence: 99%

Correlating bacterial shedding with fecal corticosterone levels and serological responses from layer hens experimentally infected with Salmonella Typhimurium

Sharma

Pande

Moyle

et al. 2017

Vet Res

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Salmonella Enteriditis and Salmonella Typhimurium are commonly isolated during egg-related outbreaks of salmonellosis and represent a significant international public health issue. In Australia, Salmonella Typhimurium is the most common serovar identified in egg product related foodborne outbreaks. While a number of studies have investigated Salmonella shedding and host responses to infection, they have been conducted over a short time period. The present study sought to characterise bacterial shedding and host responses to infection in hens infected with only Salmonella Typhimurium or co-infected with both Salmonella Typhimurium and Salmonella Mbandaka over a 16 week period. Salmonella shedding was quantified using the most probable number and qPCR methods and was highly variable over the course of the experiment. On day 1, fecal corticosterone metabolites in birds infected with Salmonella Typhimurium (674.2 ± 109.3 pg/mg) were significantly higher than control (238.0 ± 12.62 pg/mg) or co-infected (175.4 ± 8.58 pg/mg) birds. The onset of lay occurred between weeks 6–8 post-infection (pi) and Fecal corticosterone metabolite (FCM) concentrations increased in both control and co-infected birds. Antibody responses to infection were monitored in both serum and yolk samples. Salmonella Typhimurium specific antibody was lower in co-infected animals than monoinfected animals. Bacterial loads in internal organs were characterised to determine persistence. Spleen, liver and caecal tonsils were positive for bacteria in both groups, indicating that Salmonella was not cleared from the birds and internal organ colonization could serve as a reservoir for continued bacterial shedding.

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Section: Discussionmentioning

confidence: 99%