The central organization of the vagus nerve innervating the colon of the rat

Altschuler, Steven M.; Escardo, Julia; Lynn, Richard B.; Miselis, Richard R.

doi:10.1016/0016-5085(93)90419-d

Cited by 163 publications

(133 citation statements)

References 30 publications

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“…The vagal nerves innervate to the proximal and mid colon, whereas the pelvic nerves innervate to the distal colon in rats (1,4). When vagotomy is carried out, the pelvic nerves are still functioning.…”

Section: Discussionmentioning

confidence: 99%

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Nakade¹,

Fukuda²,

Iwa³

et al. 2007

American Journal of Physiology-Gastrointestinal and Liver Physi

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Although restraint stress accelerates colonic transit via a central corticotropin-releasing factor (CRF), the precise mechanism still remains unclear. We tested the hypothesis that restraint stress and central CRF stimulate colonic motility and transit via a vagal pathway and 5-HT3 receptors of the proximal colon in rats. 51Cr was injected via the catheter positioned in the proximal colon to measure colonic transit. The rats were subjected to a restraint stress for 90 min or received intracisternal injection of CRF. Ninety minutes after the administration of 51Cr, the entire colon was removed, and the geometric center (GC) was calculated. Four force transducers were sutured on the proximal, mid, and distal colon to record colonic motility. Restraint stress accelerated colonic transit (GC of 6.7 ± 0.4, n = 6) compared with nonrestraint controls (GC of 5.1 ± 0.2, n = 6). Intracisternal injection of CRF (1.0 μg) also accelerated colonic transit (GC of 7.0 ± 0.2, n = 6) compared with saline-injected group (GC of 4.6 ± 0.5, n = 6). Restraint stress-induced acceleration of colonic transit was reduced by perivagal capsaicin treatment. Intracisternal injection of CRF antagonists (10 μg astressin) abolished restraint stress-induced acceleration of colonic transit. Stimulated colonic transit and motility induced by restraint stress and CRF were significantly reduced by the intraluminal administration of 5-HT3 antagonist ondansetron (5 × 10−6 M; 1 ml) into the proximal colon. Restraint stress and intracisternal injection of CRF significantly increased the luminal content of 5-HT of the proximal colon. It is suggested that restraint stress stimulates colonic motility via central CRF and peripheral 5-HT3 receptors in conscious rats.

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Section: Discussionmentioning

confidence: 99%

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Nakade¹,

Fukuda²,

Iwa³

et al. 2007

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Our recordings were from fibres in the intermesenteric and lumbar splanchnic nerves, which together contain predominantly lumbar spinal afferents (Baron et al 1988). Sacral afferents follow a separate anatomical pathway in the pelvic nerves (Baron & J anig, 1991;J anig & Koltzenburg, 1991), and vagal fibres are relatively sparse at the level of the colon (Berthoud et al 1991(Berthoud et al , 1997Altschuler et al 1993). The pathway taken by vagal fibres is not known.…”

Section: Origins Of Fibres Recordedmentioning

confidence: 99%

In vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon

Lynn

Blackshaw

1999

The Journal of Physiology

105

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“…Bien qu'appartenant au système nerveux autonome, le SNE est sous l'influence du système nerveux central (SNC) (Wilhelmsen, 2000 ;Furness et al 2001 ;Blackshaw et al 2007). En effet, il est innervé par le nerf vague avec un gradient de densité d'innervation antéro-postérieur de l'estomac jusqu'au colon transverse (Schemann & Grundy, 1992 ;Altschuler et al 1993 ;Lebouvier et al 2009). Sa partie colique distale est innervée par le nerf pelvien.…”

Section: Organisationunclassified

Le système nerveux entérique et l’unité neuro-glio-épithéliale digestive

Neunlist¹,

Rolli–Derkinderen²

2013

bavf

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The central organization of the vagus nerve innervating the colon of the rat

Cited by 163 publications

References 30 publications

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

In vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon

Le système nerveux entérique et l’unité neuro-glio-épithéliale digestive

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The central organization of the vagus nerve innervating the colon of the rat

Cited by 163 publications

References 30 publications

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats

In vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon

Le système nerveux entérique et l’unité neuro-glio-épithéliale digestive

Contact Info

Product

Resources

About

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats