The centrifugal microfluidic Bio-Disk platform

Ducrée, Jens; Haeberle, S.; Lutz, Sascha; Pausch, Sarah; Stetten, Felix von; Zengerle, Roland

doi:10.1088/0960-1317/17/7/s07

Cited by 380 publications

(304 citation statements)

References 55 publications

(94 reference statements)

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“…Current centrifugal platforms, particularly integrated CD-based in vitro diagnostic devices, use surface treatments to implement siphon valving. 2,5,25,26 These siphon microchannels are typically treated by a plasma cleaner, but the induced hydrophilicity changes over time. To avoid surface treatments, Madou et al has proposed the pneumatic pumping technique.…”

Section: B Experimental Resultsmentioning

confidence: 99%

“…Thus, the CD-like microfluidic chip has been studied thoroughly and emerged as a unique approach to the development of integrated total analysis systems for medical diagnostics. [1][2][3][4] In CD-like microfluidic chips, siphon valve is one key component used for extraction and metering operation of the liquid phase. 2,5 As presented in Refs.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] In CD-like microfluidic chips, siphon valve is one key component used for extraction and metering operation of the liquid phase. 2,5 As presented in Refs. 2 and 5, spontaneous capillary flow is required before rotation of the centrifugal platform and induction of the siphonal flow in siphon valve.…”

Section: Introductionmentioning

confidence: 99%

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Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips

et al. 2014

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Based on the Euler force induced by the acceleration of compact disk (CD)-like microfluidic chip, this paper presents a novel actuation mechanism for siphon valving. At the preliminary stage of acceleration, the Euler force in the tangential direction of CD-like chip takes the primary place compared with the centrifugal force to function as the actuation of the flow, which fills the siphon and actuates the siphon valving. The Euler force actuation mechanism is demonstrated by the numerical solution of the phase-field based mathematical model for the flow in siphon valve. In addition, experimental validation is implemented in the polymethylmethacrylate-based CD-like microfluidic chip manufactured using CO 2 laser engraving technique. To prove the application of the proposed Euler force actuation mechanism, whole blood separation and plasma extraction has been conducted using the Euler force actuated siphon valving. The newly introduced actuation mechanism overcomes the dependence on hydrophilic capillary filling of siphon by avoiding external manipulation or surface treatments of polymeric material. The sacrifice for highly integrated processing in pneumatic pumping technique is also prevented by excluding the volume-occupied compressed air chamber. V C 2014 AIP Publishing LLC. [http://dx

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Section: B Experimental Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips

et al. 2014

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“…The primary forces enabling fluidic operations to be achieved are the centrifugal, Coriolis, and capillary forces. A number of detailed reviews of centrifugal microfluidic systems provide theoretical descriptions of the forces and their applications [3][4][5], and thus only a brief summary with example applications of each force is provided below.…”

Section: Theory Of Centrifugal Microfluidicsmentioning

confidence: 99%

Rapid, Low-Cost Prototyping of Centrifugal Microfluidic Devices for Effective Implementation of Various Microfluidic Components

Smith¹,

Land²,

Madou

et al. 2015

The South African Journal of Industrial Engineering

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A centrifugal microfluidic platform to develop various microfluidic operations -the first of its kind in South Africa -is presented. Rapid and low-cost prototyping of centrifugal microfluidic disc devices, as well as a set-up to test the devices using centrifugal forces, is described. Preliminary results show that various microfluidic operations such as fluidic valving, transportation, and microfluidic droplet generation can be achieved. This work provides a complete centrifugal microfluidic platform and the building blocks on which to develop a variety of microfluidic applications and potential products rapidly and at a low cost. OPSOMMING'n Sentrifugale mikrofluidiese platform -'n eerste in Suid-Afrika -vir die ontwikkeling van verskeie mikrofluidiese funksies word aangebied. Vinnige en lae-koste prototipering van sentrifugale mikrofluidiese skyfstrukture, asook 'n opstelling vir die toets van die strukture met sentrifugale kragte, word beskryf. Voorlopige resultate toon dat verskeie mikrofluidiese funksies soos vloeiklepping, vervoer, en druppelgenerasie haalbaar is. Hierdie werk bied 'n volledige sentrifugale mikrofluidiese platform, sowel as die boublokke waarop 'n verskeidenheid van mikrofluidiese toepassings en potensiële produkte vinnig en teen lae koste ontwikkel kan word. † This is an extended version of a paper presented at the

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“…Passive valves include capillary valves, hydrophobic valves, and siphon valves 7 . These types of valves are controlled primarily by the rotational frequency, surface properties, and channel design of the disc.…”

Section: Introductionmentioning

confidence: 99%

Phase-selective graphene oxide membranes for advanced microfluidic flow control

et al. 2016

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For the first time, we harness the unique phase-selectivity of chip-integrated graphene oxide (GO) membranes to significantly enhance flow control on centrifugal microfluidic platforms. In this paper, we present novel processes for the assembly of these GO membranes into polymeric microfluidic systems and demonstrate that multilayer GO membranes allow the passage of water while blocking pressurized air and organic solutions.

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The centrifugal microfluidic Bio-Disk platform

Cited by 380 publications

References 55 publications

Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips

Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips

Rapid, Low-Cost Prototyping of Centrifugal Microfluidic Devices for Effective Implementation of Various Microfluidic Components

Phase-selective graphene oxide membranes for advanced microfluidic flow control

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