The cephalic phase of insulin release is modulated by IL-1β

Wiedemann, Sophia J.; Trimigliozzi, Kelly; Dror, Erez; Meier, Daniel T.; Molina-Tijeras, José Alberto; Rachid, Leila; Foll, Christelle Le; Magnan, Christophe; Schulze, Florian; Stawiski, Marc; Häuselmann, Stéphanie P.; Méreau, Hélène; Böni-Schnetzler, Marianne; Donath, Marc Y.

doi:10.1016/j.cmet.2022.06.001

Cited by 35 publications

(6 citation statements)

References 64 publications

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“…We did not yet identify neurotransmitters involved in synaptic-like contacts of beta cell cilia but future studies in this direction will likely provide insights into the physiology of islet cells in health and diabetes. In particular, we speculate that such ciliary synaptic-like contacts represent a privileged site for the response of islet cells to sympathetic/parasympathetic (67) and paracrine signals. Further-more, recent work postulates that the close vicinity of cilia to synapses enables them to detect synaptic neurotransmitters (64; 63).…”

Section: Discussionmentioning

confidence: 95%

Structure, interaction, and nervous connectivity of beta cell primary cilia

Müller,

Klena,

Pang

et al. 2023

Preprint

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Primary cilia are sensory organelles present in many cell types. Based on an array of microtubules termed axoneme they form a specialized membrane compartment partaking in various signaling processes. Primary cilia of pancreatic islet beta cells play a role in autocrine and paracrine signaling and are linked to diabetes. Yet, the structural basis for their functions is unclear. We present three-dimensional reconstructions of complete mouse and human beta cell cilia, revealing a disorganized 9+0 axoneme structure. Within the islet, cilia are spatially confined within deep ciliary pockets or squeezed into narrow extracellular spaces between adjacent cells. Beta and alpha cell cilia physically interact with neighboring islet cells pushing and strongly bending their plasma membranes. Furthermore, beta cells can contain multiple cilia that can meet with other islet cell cilia in the extracellular space. Additionally, beta cell cilia establish connections with islet-projecting nerves. These findings highlight the pivotal role of beta cell primary cilia in islet cell connectivity, pointing at their potential functional role in integrating islet intrinsic and extrinsic signals. These novel insights contribute to understanding their significance in health and diabetes.

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Section: Discussionmentioning

confidence: 95%

Structure, interaction, and nervous connectivity of beta cell primary cilia

Müller,

Klena,

Pang

et al. 2023

Preprint

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“…It has both supportive and destructive effects on b-cell function, causing dysfunction with prolonged exposure and inducing insulin secretion with acute exposure (27,28,72). Brain and peritoneal macrophages secrete IL-1β to promote feeding-dependent insulin secretion (73,74).…”

Section: Discussionmentioning

confidence: 99%

Beneficial islet inflammation in health depends on pericytic TLR/MyD88 signaling

Schonblum,

Ali Naser,

Ovadia

et al. 2024

Journal of Clinical Investigation

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“…Furthermore, alterations in cellular metabolism and specific metabolites, such as FFAs from the adipose tissue, regulate IL-10 production in different immune cells [ 18 , 21 ]. Likewise, IL-1β plays a critical role in physiological and pathological metabolism modulation (energy homeostasis), including insulin action and secretion, β-cell apoptosis, lipid metabolism, and food intake, by regulating the immune system and the neuronal and endocrine systems’ interface and, hence, in metabolic disorders, such as T2DM, MetS, and obesity [ 13 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults’ Clinical Characteristics

Freitas,

de Souza Silva,

Ferreira Fratelli

et al. 2024

Nutrients

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Populational aging is marked by chronic noncommunicable diseases, such as metabolic syndrome (MetS). IL-10 and IL-1β are pleiotropic cytokines with multiple biological effects linked to metabolic disorders. This cross-sectional study assessed 193 participants’ IL-10 and IL-1β serum levels regarding their role in developing MetS, clinical characteristics, and their IL1B rs1143627 and IL10 rs1800890 variants’ genotype frequencies in a population over 60. IL-10 levels correlated weakly with HDL levels and fat mass and inversely with triglycerides, glucose, glycated hemoglobin, and estimated average blood glucose levels. IL-10 levels were also indirectly influenced by the patient’s T2DM duration, lean mass amount, and bone mineral content. Participants with altered HDL, elevated serum glucose, raised HbA1c levels, or those over 80 had reduced serum IL-10 levels compared to those with normal levels or other age groups, respectively. Women also had higher serum IL-10 levels than men. Dissimilarly, IL-1β levels correlated directly only with the number of total leukocytes and segmented neutrophils, showing only significant variations with self-reported alcohol consumption. Our study also found that those with the IL10 AA genotype (lower IL-10 levels) had a significantly higher risk of developing MetS. These findings may help direct future research and more targeted therapeutic approaches in older adults.

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The cephalic phase of insulin release is modulated by IL-1β

Cited by 35 publications

References 64 publications

Structure, interaction, and nervous connectivity of beta cell primary cilia

Structure, interaction, and nervous connectivity of beta cell primary cilia

Beneficial islet inflammation in health depends on pericytic TLR/MyD88 signaling

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults’ Clinical Characteristics

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