The cerebellar-hypothalamic circuits: Potential pathways underlying cerebellar involvement in somatic-visceral integration

Zhu, Jing-Ning; Yung, Wing‐Ho; Chow, Billy K. C.; Chan, Ying-Shing; Wang, Jianjun

doi:10.1016/j.brainresrev.2006.01.003

Cited by 183 publications

(131 citation statements)

References 114 publications

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“…The notion of the cerebellum as a universal regulator is further supported by studies showing cerebellar involvement in timing and integration of somatic and visceral information [41,42]. Observations of crossed cerebellar hypoperfusion after cortical stroke and crossed cerebello-cerebral diaschisis in patients with cerebellar stroke give further evidence for the CTCC circuit.…”

Section: Discussionmentioning

confidence: 91%

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

2008

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Several lines of evidence suggest that the cerebellum may play a role in the regulation of emotion. The aim of this study was to investigate the hypothesis that inhibition of cerebellar function using slow repetitive transcranial magnetic stimulation (rTMS) would lead to increased negative mood as a result of impaired emotion regulation. In a randomized counterbalanced within-subjects design, 12 healthy young right-handed volunteers received 20 min of cerebellar, occipital, or sham 1 Hz rTMS on three separate days. Mood state inventories were acquired prior to and immediately after rTMS and after an emotion regulation task (ERT). In the ERT, participants were instructed to either look at aversive and neutral scenes, or to suppress the negative feelings experienced while watching aversive scenes during which the electroencephalogram (EEG) was recorded. Results showing no changes in baseline-corrected mood were observed immediately after rTMS. However, significant increases in baseline-corrected negative mood following the ERT were reported after cerebellar rTMS exclusively. No effects on the EEG during the ERT were observed. These findings provide support for the view that the cerebellum is implicated in the regulation of emotion and mood, and concur with evidence of cerebellar abnormalities observed in disorders associated with emotion dysregulation. In order to clarify the underlying biological mechanisms involved, more research is needed.

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Section: Discussionmentioning

confidence: 91%

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

2008

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“…2). on the other hand, central motor structures project back to the hypothalamus, such as direct cerebellohypothalamic projections [7,8] and indirect projections from the vestibular nuclei to the hypothalamus [80] , to influence nonsomatic physiological functions. By bridging the non-somatic centers to somatic motor structures and modulating both non-somatic and somatic activity in parallel, the central orexinergic system, together with the circuits from motor structures to non-somatic centers, may actively participate in the orchestration of somatic-non-somatic integration, which is crucial for the generation and execution of appropriate and coordinated behavioral responses (including both somatic and nonsomatic components) to changes in the internal and external environments.…”

Section: Resultsmentioning

confidence: 99%

“…Clearly, an intact behavior comprises both somatic (motor) and non-somatic (e.g., visceral, emotional, and cognitive) components and requires somatic-non-somatic integration involving various brain regions and discrete neuronal pathways [7,8] . By linking the non-somatic centers to somatic motor structures, the central orexinergic system may actively participate in somatic-non-somatic integration, which is crucial for the generation and execution of appropriate and coordinated behavioral responses to changes in the internal and external environments.…”

Section: Introductionmentioning

confidence: 99%

Central functions of the orexinergic system

Zhang

Zhuang

et al. 2013

Neurosci. Bull.

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The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus. However, these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central orexinergic system. it is well known that central orexin plays a crucial role in the regulation of various basic non-somatic and somatic physiological functions, including feeding, energy homeostasis, the sleep/wake cycle, reward, addiction, and neuroendocrine, as well as motor control. Moreover, the absence of orexin results in narcolepsy-cataplexy, a simultaneous somatic and non-somatic dysfunction. in this review, we summarize these central functions of the orexinergic system and associated diseases, and suggest that this system may hold a key position in somatic-non-somatic integration.

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“…A previous study using an autoradiographic method to identify the distribution of histamine receptors indicated that the H 1 histaminergic receptors are predominant in the cerebellum of teleost fish (17). Additionally, Vonderschen et al (30) reported the existence of direct connections between the cerebellum and the telencephalon (cerebellar-hypothalamic pathways), which may constitute a communication pathway involved in the coordination of non-motor tasks, such as spatial memory tasks (31).…”

Section: Discussionmentioning

confidence: 99%

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Garção

Canto-de-Souza

Romaguera

et al. 2009

Braz J Med Biol Res

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We determined the effect of an H 1 receptor antagonist on the functional recovery of Carassius auratus submitted to telencephalic ablation. Five days after surgery the fish underwent a spatial-choice learning paradigm test. The fish, weighing 6-12 g, were divided into four groups: telencephalic ablation (A) or sham lesion (S) and saline (SAL) or chlorpheniramine (CPA, ip, 16 mg/kg). For eight consecutive days each animal was trained individually in sessions separated by 24 h (alternate days). Training trials (T1-T8) consisted of finding the food in one of the feeders, which were randomly blocked for each subject. Animals received an intraperitoneal injection of SAL or CPA 10 min after the training trials. The time spent by the animals in each group to find the food (latency) was analyzed separately at T1 and T8 by the Kruskal-Wallis test, followed by the Student Newman-Keuls test. At T1 the latencies (mean ± SEM) of the A-SAL (586.3 ± 13.6) and A-CPA (600 ± 0) groups were significantly longer than those of the S-SAL (226.14 ± 61.15) and S-CPA (356.33 ± 68.8) groups. At T8, the latencies of the A-CPA group (510.11 ± 62.2) remained higher than those of the other groups, all of which showed significantly shorter latencies (A-SAL = 301.91 ± 78.32; S-CPA = 191.58 ± 73.03; S-SAL = 90.28 ± 41) compared with T1. These results support evidence that training can lead to functional recovery of spatial-choice learning in telencephalonless fish and also that the antagonist of the H 1 receptor impairs it.

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The cerebellar-hypothalamic circuits: Potential pathways underlying cerebellar involvement in somatic-visceral integration

Cited by 183 publications

References 114 publications

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

Central functions of the orexinergic system

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

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