The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder

Wells, Elizabeth; Walsh, Karin S.; Khademian, Zarir; Keating, Robert F.; Packer, Roger J.

doi:10.1002/ddrr.25

Cited by 118 publications

(72 citation statements)

References 63 publications

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“…Significant correlations are also found between duration of mutism and abnormalities on SPECT scans of the left temporal lobe, the left and right basal nuclei, and the right frontal lobe [50]. Although the mutism is transient, speech rarely normalizes and the syndrome is associated with long-term adverse neurological, cognitive, and psychological sequelae [54]. Palmer et al showed that patients treated for medulloblastoma and suffered with cerebellar mutism, had an increased risk for neurocognitive impairment for over 12 months postoperatively [55].…”

Section: Cerebellar Mutismmentioning

confidence: 94%

Autism and Cerebellar Mutism: A Review of the Neuroanatomical Findings

Kaya¹

2012

Autism

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Autistic Spectrum Disorder (ASD) is behaviorally defined syndrome characterized by atypical social interaction, disordered verbal and non-verbal communication, restricted areas of interest and limited imaginative play. The prevalence of ASD is considered to be approximately 4 to 5 per 1000, but numbers differ according to criteria used for diagnosis [1].Individuals with ASD have three core features; 1. Impairments of reciprocal social interactions, 2. Abnormal development and use of language and 3. Repetitive and ritualized behaviors and a narrow range of interests. In addition to the core features of autism, there are common co-morbid neurological disorders. The prevalence of mental retardation in the autism spectrum is approximately 30%. Epilepsy prevalence associated with autism varies from 5% to 44%. Anxiety and mood disorders are also very common in autism.There is heterogeneity in the onset of autism. Although some children have signs of development delays between 0-18 months of life, up to 40% of children with ASD initially demonstrate the near-normal development until 18-24 months.As Brunelle et al. says: All the results are converging toward the description of anatomical and functional anomalies in the regions of the so-called "social brain" [2]. Several brain regions such as frontal lobe, the superior temporal cortex, the parietal cortex, and amygdala have been implicated in social behavior. But the recent developments make us think more about the role of cerebellum in ASD. This review presents an overview of the neuroanatomical abnormalities that occur within ASD. We discuss the findings that have advanced our understanding of cerebellar organization in ASD.

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Section: Cerebellar Mutismmentioning

confidence: 94%

Autism and Cerebellar Mutism: A Review of the Neuroanatomical Findings

Kaya¹

2012

Autism

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“…33 Posterior fossa syndrome is a broader term that includes CM and, in addition, movement disorders (ataxia and hypotonia) and a wide spectrum of neurobehavioral abnormalities. 39 Some authors regard CMS as a synonym for posterior fossa syndrome (PFS) and use the terms interchangeably, 55,82,109 while others believe that CM is a severe form of cerebellar dysarthria. 33,44,68,89,99,103,105 In 1998, Schmahmann and Sherman 84 introduced the term cerebellar cognitive affective syndrome to describe a constellation of neuropsychological findings in adult patients with diseases confined to the cerebellum.…”

Section: Definitionsmentioning

confidence: 99%

Cerebellar mutism

Pitsika¹,

Tsitouras²

2013

PED

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Mutism of cerebellar origin is a well-described clinical entity that complicates operations for posterior fossa tumors, especially in children. This review focuses on the current understanding of principal pathophysiological aspects and risk factors, epidemiology, clinical characteristics, treatment strategies, and outcome considerations. The PubMed database was searched using the term cerebellar mutism and relevant definitions to identify publications in the English-language literature. Pertinent publications were selected from the reference lists of the previously identified articles. Over the last few years an increasing number of prospective studies and reviews have provided valuable information regarding the cerebellar mutism syndrome. Importantly, the clarification of principal terminology that surrounds the wide clinical spectrum of the syndrome results in more focused research and more effective identification of this entity. In children who undergo surgery for medulloblastoma the incidence of cerebellar mutism syndrome was reported to be 24%, and significant risk factors so far are brainstem involvement and midline location of the tumor. The dentate-thalamo-cortical tracts and lesions that affect their integrity are considered significant pathophysiological issues, especially the tract that originates in the right cerebellar hemisphere. Moderate and severe forms of the cerebellar mutism syndrome are the most frequent types during the initial presentation, and the overall neurocognitive outcome is not as favorable as thought in the earlier publications. Advanced neuroimaging techniques could contribute to identification of high-risk patients preoperatively and allow for more effective surgical planning that should focus on maximal tumor resection with minimal risk to important neural structures. Properly designed multicenter trials are needed to provide stronger evidence regarding effective prevention of cerebellar mutism and the best therapeutic approaches for such patients with a combination of pharmacological agents and multidisciplinary speech and behavior augmentation.

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“…En la literatura se han descrito múltiples factores de riesgo relacionados, dentro de los más citados destacan: compromiso tumoral del tronco cerebral 4,25 , la localización en línea media 26,27 , la incisión del vermis cerebeloso 29 y la histología del tumor. En relación a este último, cabe destacar que el meduloblastoma presenta una mayor incidencia de mutismo cerebeloso postoperatorio 27,28 .…”

Section: Introductionunclassified

“…En el mutismo cerebeloso y en el síndrome de mutismo cerebeloso el sustrato anatómico más citado en la literatura tiene relación con el núcleo dentado y el tracto dento-rubro-talámico [17][18][19][20][21][22][23] .…”

Section: Introductionunclassified

Tractografía de la vía dento-rubro-talámica en mutismo cerebeloso postoperatorio en niños con tumores de fosa posterior

Cohen-Scheihing

2015

Rev. chil. neuro-psiquiatr.

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The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder

Cited by 118 publications

References 63 publications

Autism and Cerebellar Mutism: A Review of the Neuroanatomical Findings

Autism and Cerebellar Mutism: A Review of the Neuroanatomical Findings

Cerebellar mutism

Tractografía de la vía dento-rubro-talámica en mutismo cerebeloso postoperatorio en niños con tumores de fosa posterior

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