The Cerebellum and Disorders of Emotion

Schutter, Dennis J.L.G.

doi:10.1007/978-3-030-99550-8_17

Cited by 6 publications

(3 citation statements)

References 779 publications

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“…Some studies revealed that the DLPFC is strongly connected to frontal cortices that are preferentially involved in motor control [30]. FMRI studies frequently reported coactivation between the DLPFC and cerebellum during cognitive tasks [39][40][41]. Moreover, the application of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) to the DLPFC resulted in core symptom (emotion and cognition) improvement on major depression disorder (MDD) [42,43].…”

Section: Discussionmentioning

confidence: 99%

36-h Total Sleep Deprivation Induced Aberrant Insula Sub-regional Functional Connectivity

Chen¹,

Zhang

Lei

et al. 2023

Preprint

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Total sleep deprivation (TSD) induces aberrant insula functional connectivity (FC). The insula comprises at least three functionally distinct subregions: anterior dorsal (dAI), anterior ventral (vAI), and posterior insula (PI). Biased attention toward the anterior insula (AI) has limited our complete understanding of the TSD impact. We aimed to investigate TSD-induced functional connectivity and lateralization across the insula subregions. A total of 54 healthy young men completed 36-h TSD. Two sessions of psychomotor vigilance task (PVT) and 3T resting-state functional magnetic resonance imaging (rs-fMRI) scanning were carried out. A seed-based FC was conducted using bilateral insula subregions. Impaired vigilance, altered functional connectivity and lateralization were observed after TSD. The AI showed enhanced connectivity with the cerebellum, middle frontal gyrus, putamen, and postcentral gyrus but decreased connectivity with the temporal lobes, angular gyrus, calcarine sulcus, anterior cingulum, and medial orbitofrontal gyrus. The PI had increased connectivity with the middle frontal, inferior temporal, and inferior parietal gyrus but showed an anti-correlation with the middle temporal regions, posterior cingulum, and angular gyrus. All the seeds showed ipsilateral connections with specific brain regions, excluding the cerebellum. Both the vAI and PI displayed FC with the insula. The correlation analysis between PVT and brain signal changes did not survive Bonferroni correction. This study provided information about potential functional asymmetries of insula subregions caused by 36-h TSD. These findings provided new insights into the neural mechanisms of inter-hemispheric communication and coordination, which is essential for understanding the overall brain function. Keywords: rs-fMRI, insular subregions, PVT, sleep deprivation, functional connectivity

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Section: Discussionmentioning

confidence: 99%

36-h Total Sleep Deprivation Induced Aberrant Insula Sub-regional Functional Connectivity

Chen¹,

Zhang

Lei

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…The anteroventral/anteromedial together with the mediodorsal nuclei play important roles in connecting subcortical limbic structures (amygdala) to the limbic cortex (anterior cingulate and orbitofrontal cortex) [ 56 ]. In addition, the cerebello–thalamo–cortical loops are implicated in emotion regulation and subjective sense of control [ 57 ]; and aberrant intrinsic FC of the thalamocortical pathway was associated with depression [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode

Stoyanov

Khorev

Paunova

et al. 2022

IJERPH

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Aim: This study aims to develop new approaches to characterize brain networks to potentially contribute to a better understanding of mechanisms involved in depression. Method and subjects: We recruited 90 subjects: 49 healthy controls (HC) and 41 patients with a major depressive episode (MDE). All subjects underwent clinical evaluation and functional resting-state MRI. The data were processed investigating functional connectivity network measures across the two groups using Brain Connectivity Toolbox. The statistical inferences were developed at a functional network level, using a false discovery rate method. Linear discriminant analysis was used to differentiate between the two groups. Results and discussion: Significant differences in functional connectivity (FC) between depressed patients vs. healthy controls was demonstrated, with brain regions including the lingual gyrus, cerebellum, midcingulate cortex and thalamus more prominent in healthy subjects as compared to depression where the orbitofrontal cortex emerged as a key node. Linear discriminant analysis demonstrated that full-connectivity matrices were the most precise in differentiating between depression vs. health subjects. Conclusion: The study provides supportive evidence for impaired functional connectivity networks in MDE patients.

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“…In support of the hypothesis of a cerebellar role in affective regulation, the occurring of both depressive and manic symptoms has recently been reported in patients with cerebellar disease of different etiology, creating a bridge between the two disorders ( Clausi et al, 2019 ; Lupo et al, 2019 ). Though, the interest in deepening the contribution of the cerebellum in BD brain networks has increased lately ( Argyropoulos et al, 2021 ; Olivito et al, 2022a ), promoted by the plethora of studies that are nowadays available about the anatomical and functional connections that link the cerebellum and subcortical limbic and cortical associative areas involved in emotional and affective regulation ( Stoodley and Schmahmann, 2009 ; Adamaszek et al, 2017 ; Baumann and Mattingley, 2022 ; Schutter, 2022 ). In BD, the persistence of functional connectivity changes during the euthymic phases has been reported.…”

Section: Introductionmentioning

confidence: 99%

The role of the cerebellum in sequencing and predicting social and non-social events in patients with bipolar disorder

Siciliano

Olivito

Lupo³

et al. 2023

Front. Cell. Neurosci.

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IntroductionAdvances in the operational mode of the cerebellum indicate a role in sequencing and predicting non-social and social events, crucial for individuals to optimize high-order functions, such as Theory of Mind (ToM). ToM deficits have been described in patients with remitted bipolar disorders (BD). The literature on BD patients’ pathophysiology reports cerebellar alterations; however, sequential abilities have never been investigated and no study has previously focused on prediction abilities, which are needed to properly interpret events and to adapt to changes.MethodsTo address this gap, we compared the performance of BD patients in the euthymic phase with healthy controls using two tests that require predictive processing: a ToM test that require implicit sequential processing and a test that explicitly assesses sequential abilities in non-ToM functions. Additionally, patterns of cerebellar gray matter (GM) alterations were compared between BD patients and controls using voxel-based morphometry.ResultsImpaired ToM and sequential skills were detected in BD patients, specifically when tasks required a greater predictive load. Behavioral performances might be consistent with patterns of GM reduction in cerebellar lobules Crus I-II, which are involved in advanced human functions.DiscussionThese results highlight the importance of deepening the cerebellar role in sequential and prediction abilities in patients with BD.

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The Cerebellum and Disorders of Emotion

Cited by 6 publications

References 779 publications

36-h Total Sleep Deprivation Induced Aberrant Insula Sub-regional Functional Connectivity

36-h Total Sleep Deprivation Induced Aberrant Insula Sub-regional Functional Connectivity

Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode

The role of the cerebellum in sequencing and predicting social and non-social events in patients with bipolar disorder

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