The Cerebellum and Migraine

Vincent, Maurice; Hadjikhani, Nouchine

doi:10.1111/j.1526-4610.2006.00715.x

Cited by 91 publications

(86 citation statements)

References 147 publications

(249 reference statements)

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“…CGRP-containing sensory receptors activated by spreading depression in the anterior and/or posterior circulation may be responsible for the pain component of certain attacks (Vincent and Hadjikhani, 2007). A similar process in the cerebellum might account for symptoms such as dysarthria, ataxia, and dizziness during attacks of migraine (Vincent and Hadjikhani, 2007).…”

Section: The Trigeminovascular System In Migrainementioning

confidence: 99%

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Migraine and motion sickness: What is the link?

Cuomo-Granston

Drummond

2010

Progress in Neurobiology

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The brainstem is a structurally complex region, containing numerous ascending and descending fibres that converge on centres that regulate bodily functions essential to life. Afferent input from the cranial tissues and the special senses is processed, in part, in brainstem nuclei. In addition, brainstem centres modulate the flow of pain messages and other forms of sensory information to higher regions of the brain, and influence the general excitability of these cortical regions. Thus, disruptions in brainstem processing might evoke a complex range of unpleasant symptoms, vegetative changes and neurovascular disturbances and that, together, form attacks of migraine. Migraine is linked with various co-morbid conditions, the most prominent being motion sickness. Symptoms such as nausea, dizziness and headache are common to motion sickness and migraine; moreover, migraine sufferers have a heightened vulnerability to motion sickness. As both maladies involve reflexes that relay in the brainstem, symptoms may share the same neural circuitry. In consequence, subclinical interictal persistence of disturbances in these brainstem pathways could not only increase vulnerability to recurrent attacks of migraine but also increase susceptibility to motion sickness. Mechanisms that mediate symptoms of motion sickness and migraine are explored in this paper. The physiology of motion sickness and migraine is discussed, and neurotransmitters that may be involved in the manifestation of symptoms are reviewed. Recent findings have shed light on the relationship between migraine and motion sickness, and provide insights into the generation of migraine attacks.

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Section: The Trigeminovascular System In Migrainementioning

confidence: 99%

“…• Indirect influences on the vestibular nuclei, mediated by trigeminovascular reflexes that regulate blood flow through the cerebellar and vertebrobasilar vasculature (Vincent and Hadjikhani, 2007).…”

Section: Vestibular Symptomsmentioning

confidence: 99%

Migraine and motion sickness: What is the link?

Cuomo-Granston

Drummond

2010

Progress in Neurobiology

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“…Not only is an association present between Hashimoto's encephalopathy and a headache, such as a migraine (13), but there are also reports of cerebellar ataxia due to migraines (14), which are frequently accompanied by dizziness. More research on the association among cerebellar ataxia, Hashimoto encephalopathy, and migraines must be conducted in the future.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Autoantibodies and the Efficacy of Immunotherapy for Autoimmune Cerebellar Ataxia

et al. 2016

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Objective Autoimmune cerebellar ataxias were recently reported to be treatable. However, the proportion of patients with cortical cerebellar atrophy of unknown etiology with autoimmune-associated cerebellar ataxia and the actual effectiveness of immunotherapy in these diseases remain unknown. Methods We measured the level of autoantibodies (including anti-gliadin antibody, anti-glutamic acid decarboxylase (GAD) antibody, and anti-thyroid antibody) in 58 Japanese patients with cerebellar ataxia, excluding those with multiple system atrophy, hereditary spinocerebellar ataxia, cancer, or those who were receiving phenytoin, and the efficacy of immunotherapy was assessed. Results Thirty-one of 58 (53%) patients were positive for anti-GAD antibody, anti-gliadin antibody, or antithyroid antibody. Seven of the 12 anti-gliadin antibody-positive patients, three of the four anti-GAD antibody-positive patients, and three of the six anti-thyroid antibody-positive patients responded well to immunotherapy, indicating that 59% of patients with ataxia-associated antibody-positive cerebellar ataxia undergoing immunotherapy responded well. Conclusion Some patients with cerebellar ataxia have autoimmune conditions and diagnosing autoimmune cerebellar ataxia is therefore an important component in the care of patients with this disease entity.

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“…1,11,[38][39][40] Cerebellar abnormalities are thought to be the underlying cause for functional and metabolic disturbances in migraine. Brain balance changes have been recognized in migraine, but cerebellar function between or during attacks have been assessed only in a few studies.…”

Section: Discussionmentioning

confidence: 99%

“…2 In addition to the involvement of CC, cerebellar dysfunction in migraine, especially associated with specific forms of migraine has been recognized for for many years. 11 Clinical and pathophysiological evidences pointed to a connection between migraine and the cerebellum. Data documenting cerebellar abnormalities in migraine, however, is relatively scarse.…”

Section: K Ke Ey Y Wmentioning

confidence: 99%

Statistical Shape Analysis of the Corpus Callosum and the Cerebellum in Migraine Patients

Sığırlı¹,

Ozdemir²,

Ercan³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T OOb bj je ec ct ti iv ve e: : The aim of this study was to investigate the shape differences in the corpus callosum and cerebellum of migraine patients compared with healthy controls and to assess whether migraine attack frequency and disease duration are indicators for brain abnormalities in migrain cases. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included magnetic resonance imaging scans of 25 control subjects and 38 migraine patients. The data were obtained from the coordinate of landmarks analyzed with statistical shape analysis. A generalized Procrustes analysis was used to investigate shape differences. Witelson subdivision was used to further assess the regional shape differences in corpus callosum. R Re es su ul lt ts s: : The shape of the corpus callsoum in controls was significantly different from the shape in migraine patients. Migraine patients had deformations in corpus callosum compared to control patients where the most prominent deformations were seen in the posterior midbody of corpus callosum. According to Witelson subdivions deformation in in the rostral body was less prominent. There was no global or regional shape difference between patients with migraine and controls for cerebellum. No significant correlation was recognized between the size and disease duration or frequency of migraine attacks, both for corpus callosum and cerebellum. C Co on nc cl lu us si io on n: : The data suggest that migraine sufferers have global structural changes in corpus callosum but not in cerebellum, and that deformations did not vary with the disease progress. K Ke ey y W Wo or rd ds s: : Cerebellum; corpus callosum; geometric morphometrics; migraine; statistical shape analysis Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, kontrollerle karşılaştırıldığında migren hastalarının korpus kallozum ve serebellumundaki şekil farklılıklarını araştırmak ve migren atak frekansı ile hastalık süre-sinin migren hastalarında beyin anormalliklerini etkileyip etkilemediğini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma, 25 kontrol ve 38 migren hastasından elde edilen manyetik rezonans görün-tüleri kullanılarak gerçekleştirilmiştir. Mirengi noktası koordinatlarından elde edilen veriler, istatistiksel şekil analizi ile incelenmiştir. Şekil farklılıklarını değerlendirmede genelleştirilmiş Procrustes analizi kullanılmıştır. Korpus kallozumdaki bölgesel şekil farklılıklarını daha iyi değerlendirebilmek için Witelson alt bölgelendirme analizi dikkate alınmıştır. B Bu ul lg gu ul la ar r: : Korpus kallozumun şekli açısın-dan kontrol olguları ve migren hastaları arasında anlamlı bir fark bulunmuştur. Korpus kallozum için, migren hastalarında kontrollere oranla deformasyonlar olduğu gözlenmiştir. En belirgin deformasyonlar korpus kallozumun posterior orta gövdesinde gözlenmiştir. Witelson alt bölgelendirme analizine göre, korpus kallozumun rostral gövdesinde çok daha az miktarda deformasyon gözlenmiştir. Diğer taraftan, serebellum açısından, mi...

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The Cerebellum and Migraine

Cited by 91 publications

References 147 publications

Migraine and motion sickness: What is the link?

Migraine and motion sickness: What is the link?

Prevalence of Autoantibodies and the Efficacy of Immunotherapy for Autoimmune Cerebellar Ataxia

Statistical Shape Analysis of the Corpus Callosum and the Cerebellum in Migraine Patients

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