The cerebellum may be directly involved in cognitive functions

Vokaer, Mathieu; Bier, Jean Christophe; Elincx, Sandra; Claes, Thierry; Paquier, Philippe; Goldman, Serge; Bartholomé, Emmanuel; Pandolfo, Massimo

doi:10.1212/wnl.59.5.790-a

Cited by 14 publications

(1 citation statement)

References 22 publications

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“…Имеются данные, свидетельствующие о роли мозжечка и его связей в осуществлении когнитивных и эмо-ционально-аффективных функций, что не вызвано собст-венно мозжечковым двигательным дефектом [9][10][11]. Наи-более значительные когнитивные расстройства возникают при поражении задних отделов и червя мозжечка, особенно при его остром поражении (например, в острую фазу ин-сульта) [11].…”

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Falls and cerebellar ataxia

Damulin

2015

RJTAO

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Falls and cerebellar ataxia

Damulin

2015

RJTAO

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Cognitive functions in patients with MR-defined chronic focal cerebellar lesions

et al. 2007

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The aim of the present study was to examine cognitive functions in a group of chronic patients with focal cerebellar lesions. Both effects of localization (anterior vs. posterior lobe) and side (left vs. right cerebellar hemisphere) were of interest. Fourteen patients with infarctions within the territory of the posterior inferior cerebellar artery (PICA) and seven patients with infarctions within the territory of the superior cerebellar artery (SCA) participated. The affected lobules and nuclei were assessed based on 3D MR imaging. The right cerebellar hemisphere was affected in eight PICA and two SCA patients, the left hemisphere in six PICA and four SCA patients. One SCA patient revealed a bilateral lesion. In order to study possible lateralization of functions, subjects performed a language task as well as standard neglect and extinction tests. Moreover, two tests of executive functions were applied. There were no significant group differences apart from a verbal fluency task, in which all cerebellar patients - but especially those with right-sided lesions - were impaired. Voxel-based lesion-symptom mapping (VLSM) revealed that a lesion of the right hemispheric lobule Crus II was associated with impaired performance in the verbal fluency task. In sum, the results showed preserved cognitive abilities in chronic cerebellar patients apart from impairments of verbal fluency in patients with right-cerebellar lesions. The latter findings are in line with the assumption that the right posterolateral cerebellar hemisphere supports functions associated with verbal fluency.

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Cognitive Impairments in Cerebellar Infarcts

Калашникова

Zueva

Pugacheva

et al. 2005

Neurosci Behav Physiol

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The effects of the cerebellum on cognitive functions (CF) are poorly known and inadequately studied. Neurological, neuropsychological, and neuroimaging studies were performed on 25 non-random patients (14 female, 11 male, mean age 51.8 +/- 18.0 years) with isolated cerebellar infarcts. Cognitive impairments (CI) were seen in 22 patients (88%). These included impairments of attention, planning, control, abstract thought, memory, and speech disturbances (naming difficulties, irregularity of speech, agrammatism, dysprosodia), visuospatial and quasispatial disturbances, and counting impairments, demonstrating dysfunction of the anterior and posterior associative areas of the cortex. The extent of CI varied: 16 patients (64%) showed impairments only in neuropsychological tests, while six (24%) had clinically apparent impairments. Clinically significant CI developed in lesions of particular areas (posteroinferolateral and posteromedial/median) of the cerebellar cortex associated with the dominant hemisphere of the brain. The existence of clinically significant CI was independent of infarct size: infarcts were smaller (mean 5.65 cm3) in patients with marked impairments than in others (mean 12.8 cm3). The typical signs of cerebellar infarcts (ataxia, vertigo, vomiting) were seen in all patients with clinically insignificant and in only two of six patients with clinically significant CI. The present studies demonstrated the involvement of the cerebellum in the modulation of CF. The extent of CI in cerebellar infarcts depended on infarct location. The topical localizations of cerebellar zones controlling CF and movement are different.

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The cerebellum may be directly involved in cognitive functions

Cited by 14 publications

References 22 publications

Falls and cerebellar ataxia

Falls and cerebellar ataxia

Cognitive functions in patients with MR-defined chronic focal cerebellar lesions

Cognitive Impairments in Cerebellar Infarcts

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