The Challenge of Compliance and Persistence: Focus on Ulcerative Colitis

Kane, Sunanda V.; Brixner, Diana I.; Rubin, David T.; Sewitch, Maida

doi:10.18553/jmcp.2008.14.s1-a.1a

Cited by 39 publications

(39 citation statements)

References 49 publications

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“…8 Compliance and patient acceptance are essential for the success of a rectal therapy. [9][10][11][12] In general patients well accept to perform topical therapy if explained properly. 13,14 It is not the case that a topical therapy per se is associated with lower adherence and compliance.…”

Section: Introductionmentioning

confidence: 99%

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Topical therapy is underused in patients with ulcerative colitis

Seibold

Fournier

Beglinger

et al. 2014

Journal of Crohn's and Colitis

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The availability of new topical preparations for the treatment of left sided ulcerative colitis offers a therapy optimization for many patients. Rectal application of steroids and 5-aminosalicylic acid (5-ASA) is associated with fewer side effects and has a higher therapeutic efficacy in left-sided colitis as compared to a systemic therapy. Therefore, we were interested in the use of topical therapy in patients with ulcerative colitis. The key question was whether topical treatment is more frequently used than oral therapy in patients with proctitis and left sided colitis. Data of 800 patients of the Swiss IBD cohort study were analyzed. Sixteen percent of patients of the cohort had proctitis, 21% proctosigmoiditis and 41% pancolitis. Topical therapy with 5-ASA or corticosteroids was given in 26% of patients with proctitis, a combined systemic and topical treatment was given in 13%, whereas systemic treatment with 5-ASA without topical treatment was given in 29%. Proportion of topical drug use decreased with respect to disease extension from 39% for proctitis to 13.1% for pancolitis (P = 0.001). Patients with severe colitis received a significantly higher dose of topical 5-ASA than patients in remission.

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Section: Introductionmentioning

confidence: 99%

“…15,3,23 Remission also can be maintained by topical treatment of at least two years duration. [9][10][11]24,25 For maintenance 3 g of 5-ASA total per week is recommended. A topical therapy in distal UC has several advantages.…”

Section: Introductionmentioning

confidence: 99%

Topical therapy is underused in patients with ulcerative colitis

Seibold

Fournier

Beglinger

et al. 2014

Journal of Crohn's and Colitis

View full text Add to dashboard Cite

show abstract

“…[7][8][9][10][11][12][13] Multiple factors associated with nonadherence with UC medications have been identified. 6,7,[13][14][15] These factors include age, gender, newly diagnosed patient status, disease duration, copayment costs, rectal 5-ASA and glucocorticoid use, and drug type and dosing regimens. Some of these studies have reported that adherence is related to dosing regimens, while other studies have not found a correlation between these concepts.…”

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confidence: 99%

“…For example, a few studies in UC patients showed that daily dose, regimen, and formulation do not significantly impact adherence. 7,13 In addition, adherence in UC patients appears to be independent of medication formulation. 13 However, the study conducted by Loftus (2006) from a survey of 1,595 patients with UC showed the most common reasons for nonadherence were "too many pills," "dosing required too many times each day," "medication too inconvenient," and "forgetting to take medication."…”

mentioning

confidence: 99%

“…7,13 In addition, adherence in UC patients appears to be independent of medication formulation. 13 However, the study conducted by Loftus (2006) from a survey of 1,595 patients with UC showed the most common reasons for nonadherence were "too many pills," "dosing required too many times each day," "medication too inconvenient," and "forgetting to take medication." 16 Shale and Riley (2003) also identified that a 3-times-a-day regimen was associated with nonadherence.…”

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confidence: 99%

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