The Challenges and Opportunities of Classifying Childhood Arthritis

Rumsey, Dax G.; Laxer, Ronald M.

doi:10.1007/s11926-020-0880-3

Cited by 14 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most Israeli patients presented to the rheumatology clinic with axial symptoms rather than peripheral symptoms (including enthesitis). Peripheral symptoms of arthritis and enthesitis were the dominant presentation of the US group and were comparable with other reports [10][11][12][17][18][19][20][21]. These observations are supported by the significantly higher percentage of sacroiliitis on MRI upon presentation in the Israeli versus the US cohort (96.7% vs 29.7%), which were validated by the inter-center comparison, with an excellent level of agreement between the reading radiologists in the two countries.…”

Section: Discussionsupporting

confidence: 87%

“…Instead, these individuals are thus defined as undifferentiated JIA. Therefore, classification of JSpA according to the JIA classification system is inaccurate [10]. The term Juvenile Ankylosing Spondylitis (JAS) refers to the axial involvement of the disease, however, it is important to note that JAS definition is still unclear in the literature, and thus is not an official category of ILAR [10].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, classification of JSpA according to the JIA classification system is inaccurate [10]. The term Juvenile Ankylosing Spondylitis (JAS) refers to the axial involvement of the disease, however, it is important to note that JAS definition is still unclear in the literature, and thus is not an official category of ILAR [10]. No specific criteria for sole axial involvement exist for children, and adoption of adult criteria is problematic because of the unique presentation of the disease in pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study

et al. 2021

View full text Add to dashboard Cite

Background Observations among Israeli pediatric rheumatologists reveal that pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US). This study is aimed to compare the demographic and clinical variables of Israeli and US JSpA patients upon presentation. Methods We performed a retrospective, cross-sectional, multicenter comparison of JSpA patients among 3 large Israeli pediatric rheumatology centers and a large US pediatric rheumatology center. Patients with diagnosis of Juvenile Ankylosing Spondylitis (JAS) and/or Enthesitis-related Arthritis (ERA) were included. The demographic, clinical and radiologic features were compared. Results Overall 87 patients were included (39 Israeli, 48 US patients). Upon presentation, inflammatory back pain, sacroiliac joint tenderness and abnormal modified Schober test, were significantly more prevalent among Israeli patients (59% vs. 35.4, 48.7% vs. 16.7, and 41.2% vs. 21.5%, respectively, all p < 0.05), whereas peripheral arthritis and enthesitis were significantly more prevalent among US patients (43.6% vs. 91.7 and 7.7% vs. 39.6% in Israeli patients vs. US patients, p < 0.05). In addition, 96.7% of the Israeli patients versus 29.7% of the US patients demonstrated sacroiliitis on MRI (p < 0.001, N = 67). Less than one-third of the Israeli patients (32%) were HLA-B27 positive vs. 66.7% of US patients (p = 0.007). Conclusion Israeli children with JSpA presented almost exclusively with axial disease compared to US patients who were more likely to present with peripheral symptoms. HLA B27 prevalence was significantly lower in the Israeli cohort compared to the US cohort. Further studies are needed to unravel the genetic and possibly environmental factors associated with these findings.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…One of the presented here patients also did not meet the signs of arthritis. The modification of JIA criteria will allow to improve their detection and treatment [30,31].…”

Section: Discussionmentioning

confidence: 99%

Clinical variability of the systemic juvenile idiopathic arthritis course: literature review based on case series

Boyarchuk¹,

Kovalchuk²,

Kovalchuk³

et al. 2020

Reumatologia

View full text Add to dashboard Cite

Systemic juvenile idiopathic arthritis (sJIA) is a heterogeneous category of arthritis that frequently leads to disability and severe complications. The clinical cause of sJIA is very variable, which results in difficulties of disease recognition.<br /> In this literature review based on case series we outline the main challenges in diagnostic of sJIA and macrophage activation syndrome (MAS). Using the 2016 criteria for MAS diagnostic allowed to consider MAS in the diagnostically challenging cases, that confirms their sensitivity in pediatric patients. The reviewed literature showed last updates for the improvement of classification, diagnostic of sJIA and its complication. The modification of JIA criteria, initiated by Paediatric Rheumatology International Trials Organisation, will allow to improve detection and treatment of JIA. <br /> The presentation of this clinical cases and the discussion may be useful for understanding the disease cause and will help to differentiate sJIA and MAS from other disorders, and to improve treatment outcomes.

show abstract

“…• [32,35]. Очевид но, що вже найближчим часом буде запропоно вано нову номенклатурну та класифікаційну платформу діагностики ЮА [28], яка буде поєд нувати всі найкращі досягнення ACR, UELAR та ILAR.…”

Section: аб волосянко мй рейтмаєр ля іванишинunclassified

History of the term «juvenile rheumatoid arthritis», its evolution and modern interpretation

Volosyanko¹,

Rеitmаier²,

Ivanyshyn³

2020

MPU

View full text Add to dashboard Cite

В історичній послідовності викладено основні етапи розвитку дитячої ревматології з особливим ухилом на передумови виникнення терміну «ювенільний ревматоїдний артрит». Зазначено причини виокремлення цього захворювання з аналогічної патології суглобів у дорослих. Показано еволюцію номенклатури ювенільного ревматоїдного артриту, починаючи з 1946 року і до наших днів. Окремо розглядаються причини введення терміну «ювенільний ідіопатичний артрит». Викладено класифікаційні та термінологічні розбіжності щодо патології у різних країнах світу. Показано внесок визначних вчених та міжнародних організацій у вивчення цієї проблеми. Звертається увага на проблемні питання трактування номенклатури хронічних захворювань суглобів дітей в Україні і світі. Зроблено припущення, що вже найближчим часом буде запропоновано нову номенклатурну та класифікаційну платформу ювенільних артритів. Автори заявляють про відсутність конфлікту інтересів. Ключові слова: діти, ревматологія, ювенільний ревматоїдний артрит, ювенільний ідіопатичний артрит.

show abstract

The Challenges and Opportunities of Classifying Childhood Arthritis

Cited by 14 publications

References 29 publications

Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study

Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study

Clinical variability of the systemic juvenile idiopathic arthritis course: literature review based on case series

History of the term «juvenile rheumatoid arthritis», its evolution and modern interpretation

Contact Info

Product

Resources

About