Sleep has fascinated all human societies, and questions as to why we sleep, and suggested remedies for sleeplessness, can be found in the earliest written records across global cultures. The examination of sleep from a physiological and experimental perspective, however, is of relatively recent origin. One early milestone was the publication in 1913 of Le probléme physiologique du sommeil by the French scientist Henri Pieron. That Pieron's book remained a standard reference until recently tells us much about how little progress was made during the twentieth century in our understanding of 'how' or 'why' we sleep. True, Nathaniel Kleitman, known as the 'father of American sleep research', made seminal discoveries regarding the effects of sleep deprivation in the 1920s, and in 1953, with Eugene Aserinsky, he discovered the state of rapid eye movement (REM) sleep. The study of the two states of sleep, REM and non-rapid eye movement (NREM) sleep, dominated sleep research for much of the twentieth century. Yet, frustratingly, the real biological significance of these 70-90 min NREM/ REM cycles that punctuate our nightly sleep eludes us still. Sleep research has attracted an increasing number of practitioners who specialize in many different sleep pathologies, carving abnormal sleep into at least 83 different types of disorder. But in truth, the questions of how we sleep [1] or indeed why we sleep [2] are only now beginning to emerge. After more than 100 years of largely descriptive science, sleep is being understood at a mechanistic level, and with this new empirical understanding, its role in overall health is now being more fully appreciated. The development of sleep science has led, ironically, to sleep being restored to a status it once occupied in our pre-industrial past, as a key element of human mental and bodily health. In this theme issue, we consider sleep from two perspectives: (i) our current understanding of the importance of sleep to health and wellbeing and (ii) how sleep has been regarded historically, and how historical studies can inform contemporary science. Although a real understanding of NREM/REM sleep remains a relative mystery, sleep research, largely from the twenty-first century, has shown that sleep can no longer be dismissed as a luxury or as an indulgence that can be curtailed. Rather, it emerges as an essential part of our biology, defining our ability to function optimally during the conscious state. The consolidation of memory and the generation of new ideas are hugely enhanced by sleep; the clearance of toxins from the brain and the rest of the body occur while we sleep; and sleep allows us to prepare physiologically and behaviourally for the demands imposed by activity. The importance of sleep is illustrated by recent findings, showing that the lack of sleep can lead to psychosocial and physiological stress, anxiety, impulsivity, loss of empathy, loss of memory, poor decision-making, loss of attention and a negative focus. If sustained, sleep loss or disruption can predispose individu...