The challenges of wound management for hidradenitis suppurativa

Moloney, Suzanne

doi:10.12968/bjon.2022.31.4.s34

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…HS has a profound negative impact on patients and their quality of life due to disabling symptoms such as pain, scarring, and disfigurement [ 7 – 10 ]. The disease is often recognized late with delayed diagnosis, inappropriate or ineffective disease management, and unpredictable disease progression [ 11 , 12 ]. The debilitating nature of the disease can be attributed to the pain caused by skin lesions, with higher pain scores than many other skin diseases [ 13 , 14 ], as well as functional limitations due to permanent scarring resulting from severe longstanding HS [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Real-World Findings on the Characteristics and Treatment Exposures of Patients with Hidradenitis Suppurativa from US Claims Data

Garg

Naik

Alavi

et al. 2022

Dermatol Ther (Heidelb)

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Introduction Hidradenitis suppurativa (HS) is a chronic, debilitating, and painful inflammatory skin disease that significantly and negatively impacts patients’ quality of life. The prevalence of HS in the USA is estimated to be 0.10%, with worldwide reports suggesting a prevalence closer to 1%. There is limited real-world evidence available on the care of patients with HS. We aimed to evaluate the trends in clinical care and treatment in the patient population with HS in the USA in a real-world setting. Methods A cohort study was conducted using claims data from IBM MarketScan Databases, including the US Commercial Claims and Encounters with Medicare Supplemental and Coordination of Benefits (CCAE+MDCR) database and IBM US Medicaid database. Results The annual prevalence of HS increased from 0.06% (2008) to 0.14% (2017), and from 0.17% (2008) to 0.31% (2017) among CCAE+MDCR and Medicaid patients, respectively. Dermatologist visits increased from 31.9% (2008) to 47.8% (2019) in CCAE+MDCR patients, and decreased from 10.9% (2008) to 8.5% (2018) in Medicaid patients. Opioid use decreased from 45.4% (2008) to 25.5% (2019) among CCAE+MDCR patients, and from 71.3% (2008) to 48.1% (2018) among Medicaid patients. Only 8.4% of CCAE+MDCR patients and 5.8% of Medicaid patients were exposed to any biologic in 2018. Conclusions Improved care and treatment of HS over the last decade, including the emergence of new treatments, have been accompanied by an increase in awareness and reported prevalence of the disease. However, there are still gaps in access to dermatologic care and low utilization of biologic therapies among patients with HS. Infographic

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Section: Introductionmentioning

confidence: 99%

Real-World Findings on the Characteristics and Treatment Exposures of Patients with Hidradenitis Suppurativa from US Claims Data

Garg

Naik

Alavi

et al. 2022

Dermatol Ther (Heidelb)

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“…11 No guidelines or therapeutic recommendations are available in literature about optimal postsurgical wound healing. [12][13][14] T A B L E 1 Clinical outcomes in the different groups in terms of mean area, Wound Bed Score (WBS), and pain Numerical Rating Scale (NRS) were evaluated at baseline (V0) and after 4 weeks (V2) (Statistics: mean [sd]).…”

Section: Discussionmentioning

confidence: 99%

“…No guidelines or therapeutic recommendations are available in literature about optimal postsurgical wound healing. 12 , 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

Advanced wound management approaches in Hidradenitis Suppurativa postsurgical lesions

Michelucci,

Janowska,

Granieri

et al. 2023

Health Science Reports

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Key messages The most appropriate management of recurrent Hidradenitis Suppurativa (HS) lesions consists of wide surgical removal of the lesions with subsequent healing by second intention. Successful wound healing depends on the choice of an adequate wound dressing, targeted to the features of the wound. We enrolled 25 patients randomized into three groups according to the advanced dressing used in second intention healing of postsurgical wounds (standard therapy, an oxygen‐enriched oil‐based medical device with prolonged release of reactive oxygen species [ROS], ultra‐portable negative pressure therapy). Data on wound size, clinical appearance of the wound bed, and pain experienced by the patient were collected twice a week for 4 weeks No statistically significant differences were observed between the different groups evaluated. Oxygen‐enriched oil‐based medical device with prolonged release of ROS can be included in the principle of HS—tissue, inflammation, moisture, and epithelium (TIME).

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Presurgical Mapping With Ultra-high Frequency Ultrasound of Hidradenitis Suppurativa Lesions Treated With Wide Local Excision and Secondary Intention Healing

Michelucci,

Fidanzi,

Manzo Margiotta

et al. 2024

Dermatol Surg

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BACKGROUND Hidradenitis suppurativa (HS) is a challenging chronic inflammatory condition often requiring surgical intervention, such as wide local excision. Preoperative mapping with ultra-high frequency ultrasound (UHFUS) enables detailed assessment of lesion extension, particularly identifying tunnels and fistulas, facilitating surgical planning. OBJECTIVE This study aimed to analyze recurrence rates of HS lesions previously mapped with UHFUS and treated with wide excision and secondary intention healing. MATERIALS AND METHODS A retrospective single-center study enrolled 40 patients with HS undergoing wide excision surgery after UHFUS mapping. Patients were assessed weekly until complete healing and then every 3 months, evaluating clinical and sonographic signs of relapse and pain using the visual analogue scale. RESULTS Results showed a population predominantly composed of women (65%) with a mean age of 39 years and a medium HS-Hurley score of 2.5. Over a 22-month follow-up, only 10% experienced clinical relapse, achieving an 90% total remission rate. Pain scores decreased significantly from Week 0 to Week 4. CONCLUSION The study highlights the clinical challenge of HS management, particularly regarding surgical planning and lesion margin definition. The remission rate observed in this study suggests the effectiveness of UHFUS-guided surgical approaches. Future studies should extend observation periods to further validate these findings.

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The challenges of wound management for hidradenitis suppurativa

Cited by 6 publications

References 11 publications

Real-World Findings on the Characteristics and Treatment Exposures of Patients with Hidradenitis Suppurativa from US Claims Data

Real-World Findings on the Characteristics and Treatment Exposures of Patients with Hidradenitis Suppurativa from US Claims Data

Advanced wound management approaches in Hidradenitis Suppurativa postsurgical lesions

Presurgical Mapping With Ultra-high Frequency Ultrasound of Hidradenitis Suppurativa Lesions Treated With Wide Local Excision and Secondary Intention Healing

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