River deltas have been ideal locations for thriving port cities; yet, the march of industrialization and urban expansion has brought significant environmental challenges. This chapter focuses on Izmir, a port city in Turkey, formerly known as Smyrna. It explores its transition from a vibrant coastal marsh to a heavily urbanized industrial area facing ecological issues. The Meles River, a key feature of İzmir’s development, now experiences major problems, including flooding, pollution, and habitat destruction, exacerbated by poor stormwater management and unchecked urban growth. The chapter proposes strategies for adopting a multifaceted approach. Key strategies include integrating green infrastructure, restoring the river’s natural state through rewilding, and updating policies to manage urban and environmental needs. By enhancing community engagement and securing diverse funding sources, İzmir can transform the Meles River into a model of social, ecological, and economic sustainability.