ORCID ID of the author: F. Y.D. 0000-0002-6901-7404Situs inversus totalis is a rare congenital positional anomaly. We report a successful perioperative management of a 72-year-old-man with situs inversus totalis, coronary arterial disease, and lung cancer scheduled for emergency operation because of ileal perforation under general anesthesia. We recommend that patients with congenital anomalies need to be thoroughly and cautiously evaluated. By this case, we review our anesthetic administration in patients with situs inversus totalis and share our experience with our colleagues.