Offshore geological sequestration of CO2 offers a viable approach for reducing greenhouse gas emissions into the atmosphere. Strategies include injection of CO2 into the deep-ocean or ocean-floor sediments, whereby depending on pressure–temperature conditions, CO2 can be trapped physically, gravitationally, or converted to CO2 hydrate. Energy-driven research continues to also advance CO2-for-CH4 replacement strategies in the gas hydrate stability zone (GHSZ), producing methane for natural gas needs while sequestering CO2. In all cases, safe storage of CO2 requires reliable monitoring of the targeted CO2 injection sites and the integrity of the repository over time, including possible leakage. Electromagnetic technologies used for oil and gas exploration, sensitive to electrical conductivity, have long been considered an optimal monitoring method, as CO2, similar to hydrocarbons, typically exhibits lower conductivity than the surrounding medium. We apply 3D controlled-source electromagnetic (CSEM) forward modeling code to simulate an evolving CO2 reservoir in deep-ocean sediments, demonstrating sufficient sensitivity and resolution of CSEM data to detect reservoir changes even before sophisticated inversion of data. Laboratory measurements place further constraints on evaluating certain systems within the GHSZ; notably, CO2 hydrate is measurably weaker than methane hydrate, and >1 order of magnitude more conductive, properties that may affect site selection, stability, and modeling considerations.