The change of plasma galectin-3 concentrations after traumatic brain injury

Shen, Yong-Feng; Yu, Wenhua; Dong, Xiao-Qiao; Du, Qin; Yang, Dan; Wu, Gang-Qun; Zhang, Zu-Yong; Wang, Hao; Jiang, Li

doi:10.1016/j.cca.2016.02.029

Cited by 33 publications

(23 citation statements)

References 37 publications

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“…Since a recent paper reported that plasma Gal‐3 concentrations were elevated after severe traumatic brain injury (Shen et al., ), to our best knowledge, there had been a paucity of the data available on change of plasma Gal‐3 levels following aSAH. It is the first study to measure circulating Gal‐3 levels in such a group of patients with aSAH.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, circulating Gal‐3 levels had the obvious diagnostic value for mild traumatic brain injury in adults (Shan et al., ) and independently predicted the occurrence of postoperative strokes among female subjects who undergo carotid endarterectomy (Edsfeldt et al., ). Notably, plasma Gal‐3 levels had high prognostic value for severe traumatic brain injury (Shen et al., ). The above‐mentioned accumulating evidence indicates that Gal‐3 might have the potential to identify aSAH patients at risk of poor outcome.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of plasma galectin‐3 levels after aneurysmal subarachnoid hemorrhage

Liu

Zhao

et al. 2016

Brain and Behavior

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BackgroundInflammatory responses are correlated with secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Galectin‐3 (Gal‐3) is a novel biomarker reflecting inflammation status, and its elevated circulating levels are associated with poor prognosis of some inflammatory diseases. The aim of this study was to evaluate the relationship between Gal‐3 plasma levels and prognosis in a group of aSAH patients.Materials and MethodsWe assessed plasma Gal‐3 levels in 120 patients and 120 healthy individuals. 6‐month clinical outcomes included mortality and unfavorable outcome (Glasgow Outcome Scale score of 1–3). Associations of plasma Gal‐3 levels with clinical outcomes were investigated using multivariate analysis.ResultsPatients showed significantly higher Gal‐3 levels as compared to controls. Circulating Gal‐3 was significantly and independently associated with 6‐month clinical outcomes in the logistic regression analysis. Moreover, we observed a significant correlation between circulating Gal‐3 and World Federation of Neurological Surgeons scores and modified Fisher scores. Furthermore, Gal‐3 possessed high area under receiver operating characteristic curve for prognostic assessment.ConclusionOur findings indicate the associations between Gal‐3 levels and the severity and poor prognosis following aSAH. This suggests the possible role of Gal‐3 in the prognostic prediction after aSAH.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic value of plasma galectin‐3 levels after aneurysmal subarachnoid hemorrhage

Liu

Zhao

et al. 2016

Brain and Behavior

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“…Gal-3 is associated with microglial activation and proliferation in various neuropathological lesions, such as traumatic brain injury [107,108], ischemic insult [37,39], demyelination [84], and encephalitis [32]. Gal-3 is a unique marker of activated resident microglial and recruited macrophages from blood circulation [42].…”

Section: Gal-3 In Microglial and Macrophagesmentioning

confidence: 99%

Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

et al. 2020

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Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological activities in various organs, including cell proliferation, apoptotic regulation, inflammation, fibrosis, and host defense. Galectin-3 is predominantly located in the cytoplasm and expressed on the cell surface, and then often secreted into biological fluids, like serum and urine. It is also released from injured cells and inflammatory cells under various pathological conditions. Many studies have revealed that galectin-3 plays an important role as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease, viral infection, autoimmune disease, neurodegenerative disorders, and tumor formation. In particular, it has been recognized that galectin-3 is extremely useful for detecting many of these diseases in their early stages. The purpose of this article is to review and summarize the recent literature focusing on the biomarker characteristics and long-term outcome predictions of galectin-3, in not only patients with various types of diseases, but associated animal models.

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“…Recently, many reports have shown that serum galectin-3 levels were highly associated with severity and clinical outcomes of some brain injury diseases, including traumatic brain injury, intracerebral hemorrhage, and spontaneous subarachnoid hemorrhage (Liu et al, 2016;Shen et al, 2016;Yan et al, 2016), indicating that galectin-3 might be a good biomarker for neurological diseases. This study confirmed that serum galectin-3 levels were significantly elevated in postpartum ICU women, especially in delirium women, and moreover, its serum levels were correlated with serum S100B and C-reactive protein levels as well as APCHCE II scores.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, activated glia can express galectin-3 during neuroinflammation (Boza-Serrano et al, 2014;Chen, Liao, Lin, & Liu, 2014;Sirko et al, 2015). Moreover, plasma galectin-3 levels have close relation to inflammation, disease severity, and clinical outcome in traumatic brain injury, aneurysmal subarachnoid hemorrhage, and spontaneous intracerebral hemorrhage (Liu, Liu, Zhao, Liu, & He, 2016;Shen et al, 2016;Yan et al, 2016). Thus, galectin-3 might reflect extent of brain injury and inflammatory status in some neurological diseases.…”

Section: Introductionmentioning

confidence: 99%

Serum galectin‐3 levels and delirium among postpartum intensive care unit women

Zhu

et al. 2017

Brain and Behavior

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Objective: Inflammation correlates with delirium. Galectin-3 is a proinflammatory protein. This study aimed to determine relation of serum galectin-3 levels to delirium of postpartum intensive care unit (ICU) women. Materials and Methods:In this prospective observational study, serum galectin-3, S100B, and C-reactive protein levels of 412 postpartum ICU women and 412 healthy women were measured. Delirium and Acute Physiology and Chronic Health Care Evaluation II (APCHCE II) scores were recorded.Results: Serum levels of galectin-3, S100B, and C-reactive protein were significantly elevated in the postpartum women than in the healthy women. Galectin-3 levels were highly associated with APCHCE II scores and S100B and C-reactive protein levels.Galectin-3, C-reactive protein, and S100B levels and APCHCE II scores were identified as independent predictors for delirium. Area under the curve (AUC) of serum galectin-3 levels was similar to that of S100B levels, and significantly exceeded those of Creactive protein levels and APCHCE II scores. Moreover, galectin-3 significantly improved the AUCs of APCHCE II scores, S100B levels, and C-reactive protein levels. Conclusions:Galectin-3, involved in inflammatory process underlying delirium-related brain injury, might be a potential biomarker to predict delirium of postpartum ICU women. K E Y W O R D Sdelirium, galectin-3, intensive care unit, postpartum, women

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The change of plasma galectin-3 concentrations after traumatic brain injury

Cited by 33 publications

References 37 publications

Prognostic value of plasma galectin‐3 levels after aneurysmal subarachnoid hemorrhage

Prognostic value of plasma galectin‐3 levels after aneurysmal subarachnoid hemorrhage

Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

Serum galectin‐3 levels and delirium among postpartum intensive care unit women

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