The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives

Kim, Ho Jung; Yoon, Young Moo; Park, Kyung Nam

doi:10.3346/jkms.1994.9.5.388

Cited by 15 publications

(7 citation statements)

References 5 publications

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“…This could suggest a relative improvement of animals receiving probiotics and could be related to the beneficial effects observed by the probiotic treatment in fecal consistency. In relation to the challenge effects, we suspect that too mild symptoms, acuteness of diarrhea and inter-individual variability promoted by our oral challenge could explain the scarce differences found, considering that changes depend on the cause of diarrhea, its severity and chronicity [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

et al. 2017

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BackgroundThe weaning pig is used as an experimental model to assess the impact of diet on intestinal health. Blood parameters (BP) are considered a useful tool in humans, but there is very scarce information of such indicators in the weaning pig. The objective of the present study is to evaluate the use of different BP as indicators in an experimental model of salmonellosis.MethodologySeventy-two 28-day-old piglets were divided into four groups in a 2x2 factorial arrangement, with animals receiving or not a probiotic combination based on B. infantis IM1® and B. lactis BPL6 (109 colony forming units (cfu)/d) and orally challenged or not a week later with Salmonella Typhimurium (5x108 cfu). Blood samples of one animal per pen (N = 24) were taken four days post-inoculation for the evaluation of different BP using an I-stat® System and of plasmatic concentrations of zinc, iron and copper.Principal findingsResults reported marginal deficiencies of zinc in piglets at weaning. Moreover, plasmatic zinc, copper and iron presented good correlations with weight gain (r 0.57, r -0.67, r 0.54 respectively; P < 0.01). Blood electrolytes (Na+, Cl- and K+) decreased (P < 0.01) only when the performance of the animals was seriously compromised and clinical symptoms were more apparent. Acid-base balance parameters such as HCO3-, TCO2 and BEecf significantly correlated with weight gain, but only in the challenged animals (r -0.54, r -0.55, and r -0.51, respectively; P < 0.05), suggesting metabolic acidosis depending on Salmonella infection. Glucose was affected by the challenge (P = 0.040), while Htc and Hgb increased with the challenge and decreased with the probiotic (P < 0.05). Furthermore, correlations of Glu, Htc and Hgb with weight gain were observed (P < 0.05). Overall, BP could be regarded as simple, useful indexes to assess performance and health of weaning piglets.

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Section: Discussionmentioning

confidence: 99%

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

et al. 2017

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“…Mechanical bowel preparation is also known to have detrimental effects, e.g. metabolic acidosis, hyponatraemia, hypokalaemia, and hypochloraemia [9,10]. It might have therefore also affected the recovery times after RC.…”

Section: Discussionmentioning

confidence: 99%

Introduction of an enhanced recovery protocol for radical cystectomy

et al. 2008

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OBJECTIVE To describe and assess an enhanced recovery protocol (ERP) for the peri‐operative management of patients undergoing radical cystectomy (RC), which was started at our institution on 1 October 2005, as RC is associated with increased morbidity and longer inpatient stays than other major urological procedures. PATIENTS AND METHODS An ERP was introduced in our institution that focused on reduced bowel preparation, and standardized feeding and analgesic regimens. In all, 112 consecutive patients were compared, i.e. 56 before implementing the ERP and 56 since introducing the ERP. The primary outcome measures were duration of total inpatient stay and interval from surgery to discharge, and the morbidity and mortality. Data were analysed retrospectively from cancer network and hospital records. RESULTS The demographics of the two groups showed no significant difference in age, gender distribution, American Society of Anesthesiologists grade, or type of urinary diversion. Re‐admission, mortality and morbidity rates showed no statistically significant difference between the groups. The median (interquartile range) duration of hospital stay was 17 (15–23) days in the no‐ERP group, and 13 (11–17) days in the ERP group (significantly different, P < 0.001, Wilcoxon rank‐sum test). The median duration of recovery after RC was 15 (13–21) days in the no‐ERP group and 12 (10–15) days in the ERP group (significantly different, P = 0.001, Wilcoxon rank‐sum test). CONCLUSION The introduction of an ERP was associated with significantly reduced hospital stay, with no deleterious effect on morbidity or mortality.

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“…Some clinical trials found no significant benefits obtained from preoperative bowel preparation [30,31,32,33], and the related meta-analyses also drew similar disappointed conclusions [7,8,34]. In addition, some studies pointed out that this intervention can cause some adverse effects for patients, such as metabolic disturbances and intestinal mucosal architectural change, which both may adversely affect patients' rehabilitation after surgery [35,36]. …”

Section: Discussionmentioning

confidence: 99%

The Role of Mechanical Bowel Preparation before Ileal Urinary Diversion: A Systematic Review and Meta-Analysis

et al. 2014

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Background: Although the use of mechanical bowel preparation (MBP) is still widely promoted as the dogma before patients undergo ileal urinary diversion, an increasing number of clinical trials have suggested that there is no benefit. Thus, we performed a meta-analysis to evaluate the efficacy of MBP in ileal urinary diversion surgery. Methods: A literature search was performed in electronic databases, including PubMed, Embase, Science Citation Index Expanded as well as the Cochrane Library and the Cochrane Clinical Trials Registry, from 1966 to January 1, 2013. Clinical trials comparing outcomes of MBP versus no MBP for ileal urinary diversion surgery were included in the meta-analysis. Pooled odds ratios with 95% confidence intervals were calculated using the fixed- or random-effects models. Results: In total, two randomized controlled trials and five cohort studies were included in this meta-analysis. The primary outcomes, such as bowel leak and bowel obstruction, showed no statistical difference between the two groups. Additionally, the overall mortality rate and death rate related to operation also manifested that MBP does not offer an advantage over the no MBP. Conclusion: This meta-analysis suggests that MBP does not reduce the incidence of perioperative complications in urinary diversion compared with no MBP. However, large randomized controlled clinical trials are needed to confirm this finding.

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The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives

Cited by 15 publications

References 5 publications

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

Introduction of an enhanced recovery protocol for radical cystectomy

The Role of Mechanical Bowel Preparation before Ileal Urinary Diversion: A Systematic Review and Meta-Analysis

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