The Changes in Plasma Retinol-Binding Protein 4 Levels are Associated With Those of the Apolipoprotein B-Containing Lipoproteins During Dietary and Drug Treatment

Christou, Georgios A; Tellis, Constantinos C.; Elisaf, Moses; Tselepis, Alexandros D.; Kiortsis, Dimitrios N.

doi:10.1177/0003319711407628

Cited by 16 publications

(14 citation statements)

References 39 publications

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“…Thus, it cannot be concluded whether the administration of orlistat or sibutramine has any additive impact on the reduction of circulating RBP 4 apart from the caloric restriction. As for the impact of CB1 blockers on RBP 4 , there is only one study in humans, which was performed by our group [ 64 ] . In this study, it was found that rimonabant treatment along with a dietary intervention of obese subjects with hypertriglyceridemia for 3 months resulted in reduction of circulating RBP 4 and circulating RBP 4 was positively correlated with the percentage change of HOMA-index [ 64 ] .…”

Section: Pharmacotherapy ( • ▶ Table 1 )mentioning

confidence: 99%

“…As for the impact of CB1 blockers on RBP 4 , there is only one study in humans, which was performed by our group [ 64 ] . In this study, it was found that rimonabant treatment along with a dietary intervention of obese subjects with hypertriglyceridemia for 3 months resulted in reduction of circulating RBP 4 and circulating RBP 4 was positively correlated with the percentage change of HOMA-index [ 64 ] . A possible mechanism for the rimonabantinduced reduction in circulating RBP 4 is the decrease in excretion of RBP 4 from adipose tissue, as indicated by a study showing that rimonabant treatment reduced RBP 4 mRNA expression in visceral adipose tissue of ob/ob mice [ 80 ] .…”

Section: Pharmacotherapy ( • ▶ Table 1 )mentioning

confidence: 99%

“…Importantly, almost all of the relevant studies reported an association of RBP 4 with TRG. Furthermore, a study by our group investigated the relationship between the changes in circulating RBP 4 and the changes in parameters of lipoprotein metabolism, during medical interventions that alter the lipoprotein profi le [ 64 ] . Specifi cally, in this study obese, hypertriglyceridemic patients followed dietary or fenofi brate treatment for 3 months.…”

Section: Lipoprotein Metabolism ▼ Relationship Between Rbp 4 and Lipimentioning

confidence: 99%

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The Metabolic Role of Retinol Binding Protein 4: An Update

Christou

Tselepis²,

Kiortsis

2011

Horm Metab Res

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reviews investigating thoroughly all the metabolic eff ects of RBP 4. In this context, this article reviews the major aspects of the possible metabolic actions of RBP 4 and attempts to elucidate any resting confusion on this matter. The literature search was based on PubMed listings up to 1 August 2011. Type 2 Diabetes and Insulin Resistance ▼ Relationship between RBP 4 and clinical and laboratory parameters of insulin resistance Circulating RBP 4 and expression of RBP 4 mRNA in abdominal adipose tissue are increased in subjects with type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT), compared to subjects with normal glucose tolerance (NGT) [ 5-7 ]. However, circulating RBP 4 and synthesis rates of RBP 4 appear to be lower in type 1 diabetes mellitus (T1DM) compared to normal, nondiabetic individuals [ 8-11 ]. Furthermore, circulating RBP 4 is higher in women with gestational diabetes mellitus compared to healthy pregnant women [ 12 , 13 ]. Moreover, in nonobese, normoglycemic subjects with at least one fi rst-degree relative with T2DM, serum RBP 4 levels correlate inversely with the glucose disposal rate (GDR), which is a

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Section: Pharmacotherapy ( • ▶ Table 1 )mentioning

confidence: 99%

Section: Pharmacotherapy ( • ▶ Table 1 )mentioning

confidence: 99%

Section: Lipoprotein Metabolism ▼ Relationship Between Rbp 4 and Lipimentioning

confidence: 99%

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The Metabolic Role of Retinol Binding Protein 4: An Update

Christou

Tselepis²,

Kiortsis

2011

Horm Metab Res

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“…10 After electrophoresis, very low-density lipoprotein (VLDL) remained at the origin [retention factor (Rf) = 0.0], HDL migrated to the front (Rf=1.0). In between, several bands can be detected: MID bands C, B, and A, which correspond mainly to intermediate-density lipoprotein (IDL), as well as up to 7 LDL bands.…”

Section: Ldl Subclass Analysismentioning

confidence: 99%

“…10,12 Non-HDL-cholesterol was calculated as TC-HDL-C. Serum apolipoprotein (Apo) A-I and ApoB levels were measured with a Behring Holding GmbH analyzer (Liederbach, Germany).…”

Section: Routine Biochemical Measurementsmentioning

confidence: 99%

The relationship between retinol-binding protein 4 and apolipoprotein B-containing lipoproteins is attenuated in patients with very high serum triglycerides: A pilot study

Christou¹,

Tellis²,

Elisaf³

et al. 2016

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oBJectIVe: the investigation of the association between retinol-binding protein 4 (RBP4) and lipoproteins in subjects with hypertriglyceridemia. desIGn: forty-six obese or overweight hypertriglyceridemic patients were studied at baseline and 20 of them underwent a hypocaloric low-fat diet for 3 months. ResuLts: Plasma RBP4 levels were positively correlated with serum triglycerides (tG) in the subgroup of patients with tG <200 mg/dL (r=0.453, p=0.039) and negatively correlated with TG in patients with TG ≥200 mg/dL (r=-0.487, p=0.019). In the subgroup with tG <200 mg/ dL, subjects with circulating RBP4 above the median 46 mg/L had higher levels of intermediate density lipoprotein-cholesterol (IdL-c), low-density lipoproteincholesterol (LdL-c) and apolipoprotein B (ApoB), while these differences were absent in patients with TG ≥200 mg/dL. The associations of percentage changes of circulating RBP4 with the percentage changes of LdL-c, very low-density lipoprotein-cholesterol (VLdL-c) and ApoB were positive after the first month and 3 months of diet for patients with baseline TG <200 mg/dL, while no correlations existed for patients with TG ≥200 mg/dL. CONCLUsIons: the positive association between circulating RBP4 and ApoB-containing lipoproteins in a steady metabolic state, as well as during a hypocaloric diet, appears to be attenuated in patients with very high tG.

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Associations of RBP4 with lipid metabolism and renal function in diabetes mellitus

Wang

Song

et al. 2013

Euro J Lipid Sci & Tech

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To investigate the plasma retinol-binding protein 4 (RBP4), small dense low-density lipoprotein cholesterol (sdLDL-C), oxidized low-density lipoprotein (ox-LDL) levels and to evaluate the associations of RBP4 with abnormal lipid metabolism and renal dysfunction in type 2 diabetes mellitus (T2DM) patients, we determined RBP4, sdLDL-C, ox-LDL levels and renal parameters in 120 T2DM patients with or without nephropathy and 70 controls. The correlation analysis and multiple linear regression analysis were performed. Compared with controls, the RBP4 and sdLDL-C levels were found significantly increased only in diabetic nephropathy (DN) patients and ox-LDL levels were elevated in both groups of T2DM patients. The RBP4 levels were positively correlated with sdLDL-C, ox-LDL, and negatively with estimated glomerular filtration rate (eGFR) in all the T2DM patients. Multiple linear regression analysis showed that sdLDL-C and eGFR were the independent predictors of RBP4 levels, and RBP4 were one of the independent determinants for sdLDL-C and ox-LDL levels in T2DM patients, respectively. In conclusion, plasma RBP4, sdLDL-C, ox-LDL levels were significantly increased in DN patients. Circulating RBP4 may be associated with abnormal lipid metabolism and renal dysfunction, and considered as a biomarker of cardiovascular disease and renal function in T2DM patients. Practical applications:The findings in the present study support the hypothesis that circulating RBP4 not only plays an important role in lipid metabolism abnormalities of atherosclerosis, contributing to the increased risk of CVD, but also could reflect renal dysfunction and be associated with the severity of nephropathy in T2DM patients. Therefore, the clinical monitoring of plasma RBP4 level as well as its dynamic changes may possess distinctly clinical value for assessments of renal function and CVD risk in T2DM patients. These findings may contribute to the further understanding of the pathogenic role of circulating RBP4 in proatherogenic dyslipidemia and nephropathy in T2DM.

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The Changes in Plasma Retinol-Binding Protein 4 Levels are Associated With Those of the Apolipoprotein B-Containing Lipoproteins During Dietary and Drug Treatment

Cited by 16 publications

References 39 publications

The Metabolic Role of Retinol Binding Protein 4: An Update

The Metabolic Role of Retinol Binding Protein 4: An Update

The relationship between retinol-binding protein 4 and apolipoprotein B-containing lipoproteins is attenuated in patients with very high serum triglycerides: A pilot study

Associations of RBP4 with lipid metabolism and renal function in diabetes mellitus

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