Thе article describes the methodological approach to the assessment of the neurophysiological status of patients undergoing transcatheter aortic valve implantation, including cognitive screening, extended neuropsychological testing with the identification of postoperative cognitive dysfunction and electroencephalographic study used in daily practice at the Federal State Budgetary Institution “Research Institute of Complex Issues of Cardiovascular Diseases”, Kemerovo. The approach was illustrated by a clinical case. The neurophysiological method demonstrated an informational value and satisfactory individual tolerance. The patient, an elderly female, had postoperative cognitive dysfunction and cortical dysfunction as revealed by postoperative dynamics of cognitive and electroencephalographic parameters.