The changes of respiratory microbiome between mild and severe asthma patients

Wang, Qunzhi; Guo, An Chi; Sheng, Meiling; Zhou, Hua

doi:10.1111/1348-0421.12881

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Nine microbial metabolic pathways were enriched in high-IgA subjects, including fucose degradation and super pathways responsible for arginine and polyamine biosynthesis. Most of these pathways, especially the sugar metabolism-related pathways, could play immunomodulatory roles (e.g., inflammation and T-cell modulation) once transmitted from breast milk to the infant gut 26 – 29 . For example, sucrose degradation IV (sucrose phosphorylase) (PWY-5384) and glucose and glucose-1-phosphate degradation (GLUCOSE1PMETAB-PWY) pathways were the most significant pathways enriched in newborn feces compared to breast milk, with the former pathway being found in the Bifidobacterium genus 20 .…”

Section: Discussionmentioning

confidence: 99%

COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition

Zhao,

Lok,

Sin

et al. 2023

npj Vaccines

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Newborns can acquire immunological protection to SARS-CoV-2 through vaccine-conferred antibodies in human breast milk. However, there are some concerns around lactating mothers with regards to potential short- and long-term adverse events and vaccine-induced changes to their breast milk microbiome composition, which helps shape the early-life microbiome. Thus, we sought to explore if SARS-CoV-2 mRNA vaccine could change breast milk microbiota and how the changes impact the levels of antibodies in breast milk. We recruited 49 lactating mothers from Hong Kong who received two doses of BNT162b2 vaccine between June 2021 and August 2021. Breast milk samples were self-collected by participants pre-vaccination, one week post-first dose, one week post-second dose, and one month post-second dose. The levels of SARS-CoV-2 spike-specific IgA and IgG in breast milk peaked at one week post-second dose. Subsequently, the levels of both antibodies rapidly waned in breast milk, with IgA levels returning to baseline levels one month post-second dose. The richness and composition of human breast milk microbiota changed dynamically throughout the vaccination regimen, but the abundances of beneficial microbes such as Bifidobacterium species did not significantly change after vaccination. Additionally, we found that baseline breast milk bacterial composition can predict spike-specific IgA levels at one week post-second dose (Area Under Curve: 0.72, 95% confidence interval: 0.58–0.85). Taken together, our results identified specific breast milk microbiota markers associated with high levels of IgA in the breast milk following BNT162b2 vaccine. Furthermore, in lactating mothers, BNT162b2 vaccines did not significantly reduce probiotic species in breast milk.

show abstract

Section: Discussionmentioning

confidence: 99%

COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition

Zhao,

Lok,

Sin

et al. 2023

npj Vaccines

View full text Add to dashboard Cite

show abstract

“…Nine microbial metabolic pathways were enriched in high-IgA subjects, including fucose degradation and super pathways responsible for arginine and polyamine biosynthesis. Most of these pathways, especially the sugar metabolism-related pathways, could play immunomodulatory roles (e.g., in ammation and T-cell modulation) once transmitted from breast milk to the infant gut [34][35][36][37] . For example, sucrose degradation IV (sucrose phosphorylase) (PWY-5384) and glucose and glucose-1-phosphate degradation (GLUCOSE1PMETAB-PWY) pathways were the most signi cant pathways enriched in newborn feces compared to breast milk, with the former pathway being found in the Bi dobacterium genus 25 .…”

Section: Discussionmentioning

confidence: 99%

COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition

Zhao

Lok

Sin

et al. 2023

Preprint

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Newborns can acquire immunological protection to SARS-CoV-2 through vaccine-conferred antibodies in human breast milk. However, there are some concerns around lactating mothers with regards to potential short- and long-term adverse events and vaccine-induced changes to their breast milk microbiome composition, which helps shape the early-life microbiome. Here, we recruited 49 lactating mothers from Hong Kong who received two doses of BNT162b2 vaccine between June 2021 and August 2021. Breast milk samples were self-collected by participating mothers pre-vaccination, one week post-first dose, one week post-second dose, and one month post-second dose. The levels of SARS-CoV-2 spike-specific IgA and IgG in breast milk peaked at one week post-second dose. Subsequently, the levels of both antibodies rapidly waned in breast milk, with IgA levels returning to baseline levels one month post-second dose. The richness and composition of human breast milk microbiota changed dynamically throughout the vaccination regimen, but the abundances of beneficial microbes such as Bifidobacterium species did not significantly change after vaccination. In addition, we found that baseline breast milk bacterial composition can predict spike-specific IgA levels at one week post-second dose (Area Under Curve: 0.72, 95% confidence interval: 0.58–0.85). Taken together, our results suggest that infants may acquire immunological protection from breast milk from SARS-CoV-2-vaccinated mothers by both the vertical transmission of antibodies and beneficial microbiota.

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“…Several pathophysiological mechanisms have been hypothesized to underlie these findings and require data to either support or refute these theories. Emerging paediatric research has documented disruptions to the gut microbiome across a range of chronic health conditions, including asthma (Patrick et al, 2020; Wang et al, 2021), ASD (Iglesias-Vazquez et al, 2020), ADHD (Ligezka et al, 2021), and cystic fibrosis (Nielsen et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The gut microbiome in children with mood, anxiety, and neurodevelopmental disorders: An umbrella review

Romano,

Shah,

Schumacher

et al. 2023

Gut. Microb.

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Research on the gut microbiome and mental health among children and adolescents is growing. This umbrella review provides a high-level overview of current evidence syntheses to amalgamate current research and inform future directions. Searches were conducted across seven databases for peer-reviewed pediatric (<18 years) review literature. Studies reporting gut microbiome composition and/or biotic supplementation on depression, bipolar disorder, anxiety, attention deficit hyperactivity disorder, autism spectrum disorder (ASD), or obsessive-compulsive disorder (OCD) were included. Deduplication and screening took place in Covidence. A sensitivity analysis was conducted to assess the degree of primary study overlap. Among the 39 included review studies, 23 (59%) were observational and 16 (41%) were interventional. Most reviews (92%) focused on ASD. Over half (56%) of the observational and interventional reviews scored low or critically low for methodological quality. A higher abundance of Clostridium clusters and a lower abundance of Bifidobacterium were consistently observed in ASD studies. Biotic supplementation was associated with ASD symptom improvement. Gut microbiome-mental health evidence syntheses in child and youth depression, anxiety, bipolar disorder, and OCD are lacking. Preliminary evidence suggests an association between specific microbiota and ASD symptoms, with some evidence supporting a role for probiotic supplementation ASD therapy.

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The changes of respiratory microbiome between mild and severe asthma patients

Cited by 5 publications

References 41 publications

COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition

COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition

COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition

The gut microbiome in children with mood, anxiety, and neurodevelopmental disorders: An umbrella review

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