The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia

İlhan, Nevin; Şi̇mşek, Mehmet

doi:10.1016/s0009-9120(02)00336-3

Cited by 78 publications

(61 citation statements)

References 38 publications

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“…Zinc levels of subjects kept decreasing during pregnancy from first trimester to third trimester. Similar results were shown in other studies in Turkey [17] and in China [9]. The decline may be explained by a disproportionate increase in plasma volume, as well as the maternal-fetal transfer.…”

Section: Discussionsupporting

confidence: 90%

Serum Level of Some Minerals during Three Trimesters of Pregnancy in Iranian Women and Their Newborns: A Longitudinal Study

Tabrizi

Pakdel

2013

Ind J Clin Biochem

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Concentrations of various trace elements are altered during pregnancy with changes in the mother's physiology and the requirements of growing fetus. The aim of the present longitudinal study was to learn the changes of micronutrients Iron (Fe), Calcium (Ca), zinc (Zn) Magnesium (Mg) and copper (Cu) of pregnant woman and their relations with newborns levels. Serum levels of iron, calcium, zinc, magnesium and copper of 162 pregnant women and their newborns were determined by an inductively couple plasma mass spectrometer (ICP/MS). The results showed that majority (41 %) of pregnant women were in age group 26-36 years 55 % had high school and diploma levels of education and the total income ranged between 3 and 5 Rials million per month There was significant difference in iron levels during first, second and third trimesters, 76.0 ± 17.8, 63.5 ± 15.2 and 70.1 ± 14.4 lg/dl respectively. Significant difference was shown in zinc levels 79.5 ± 15, 74.5 ± 16.1, and 65.3 ± 14.9 lg/dl during three trimesters. Copper levels during pregnancy were significantly different (130.9 ± 43.5, 172.0 ± 38.94, 193.2 ± 28.5 lg/dl. The serum levels of calcium and magnesium during pregnancy were constant (Ca: 8.96 ± 0.48, 8.86 ± 0.47, 8.91 ± 0.42 mg/dl and Mg: 2.10 ± 0.21, 2.08 ± 0.28, 2.09 ± 0.29 mg/dl). Results showed that 13 % of pregnant women had hypocalcaemia and hypomagnesaemia. Thirty eight percent and 42 % of pregnant women had iron and zinc deficiency respectively. In this study, unlike zinc, no pregnant women were found deficient in serum copper levels. Calcium, iron, zinc, copper and magnesium levels in the newborn's cord blood were 8.93 ± 0.43, 106.0 ± 26.1, 85.35 ± 16.6, 57.04 ± 13.8 and 1.99 ± 0.27 mg/dl respectively. In the present study the levels of iron and zinc in cord blood were higher than the levels of iron and zinc in maternal serum. The mean level of copper in cord blood serum in the current study was lower than maternal values. The mean serum calcium and magnesium in the serum cord blood and in the serum of the pregnant women were similar.

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Section: Discussionsupporting

confidence: 90%

Serum Level of Some Minerals during Three Trimesters of Pregnancy in Iranian Women and Their Newborns: A Longitudinal Study

Tabrizi

Pakdel

2013

Ind J Clin Biochem

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“…Significant changes in serum trace metal concentrations, particularly Zn and Cu, have been documented during normal pregnancies. 16 In pre-eclampsia, decreased maternal and fetal serum Zn levels have been recorded, 35 -37 and the lowered Zn concentrations have been suggested to be at least partly a result of reduced levels of oestrogen and Zn binding protein. 37 The present study also showed a decreased level of serum Zn in pre-eclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…15 Serum or placental zinc (Zn) concentrations have been reported to be low in pre-eclamptic women. 16 For Cu as with Zn, there is however considerable inconsistency in results concerning the relationship between maternal plasma concentrations and pre-eclampsia. 16,17 Some metals are essential to maintain the human body's metabolism, but they can lead to poisoning as a result of bioaccumulation.…”

Section: Introductionmentioning

confidence: 99%

“…16 For Cu as with Zn, there is however considerable inconsistency in results concerning the relationship between maternal plasma concentrations and pre-eclampsia. 16,17 Some metals are essential to maintain the human body's metabolism, but they can lead to poisoning as a result of bioaccumulation. 18 Lead (Pb) and cadmium (Cd) increase oxidative stress, 19 The inclusion criteria for entry into the study were: normal blood pressure during the first 20 weeks of gestation (for PE women); no previous history of metabolic disorders, renal disease, chronic hypertension or diabetes mellitus; and no history of antioxidant, antihypertensive medication, or aspirin intake.…”

Section: Introductionmentioning

confidence: 99%

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Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia

et al. 2008

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Catalase (antioxidant enzyme) activity in erythrocytes and serum levels of trace elements (copper, iron, zinc), heavy metals (cadmium, cobalt) and vitamins A (retinol), D (cholecalciferol) and E (atocopherol) were measured in 145 subjects comprising 47 pre-eclamptic pregnant women (PE), 48 healthy pregnant women (HP) and 50 healthy non-pregnant controls (NP). Catalase, vitamins A, D and E and levels of cobalt were significantly lower in the PE group compared with the HP and NP groups, whereas levels of copper, iron and cadmium were significantly higher in the PE group than in the HP and NP groups. Levels of zinc were significantly lower in both the PE and HP groups compared with the NP group. This assessment of oxidant/ antioxidant imbalance in pregnant women could be useful in the early identification of pre-eclampsia and antioxidant supplementation in the early weeks of gestation might be useful.

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“…This may be related to t h e higher ceruloplasmin levels in these groups. This is because the method that is used for copper measurement, determines the copper which is bound to ceruloplasmin [19,20].…”

Section: Discussionmentioning

confidence: 99%

Some mineral, trace element and heavy metal concentrations in newborns with esophageal atresia and their mothers

et al. 2014

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The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia

Cited by 78 publications

References 38 publications

Serum Level of Some Minerals during Three Trimesters of Pregnancy in Iranian Women and Their Newborns: A Longitudinal Study

Serum Level of Some Minerals during Three Trimesters of Pregnancy in Iranian Women and Their Newborns: A Longitudinal Study

Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia

Some mineral, trace element and heavy metal concentrations in newborns with esophageal atresia and their mothers

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