The changing and dynamic epidemiology of meningococcal disease

Patterns of child death in England and Wales

“…While the incidence of invasive meningococcal disease has declined in the last decade, the United Kingdom has a higher incidence than elsewhere in Europe (17:100,000 under 5 year olds compared to 7.37:100,000 for Europe as a whole). 36,37 In keeping with changes seen following the introduction of other vaccines, the development of novel vaccines against the most common serotype B strain may dramatically change the epidemiology of meningococcal disease in the future. 38,39 Cancer statistics in children are largely classified using a system that takes into account both the site and the histology of the tumour.…”

Oral administration of recombinantNeisseria meningitidisPorA genetically fused toH. pyloriHpaA antigen increases antibody levels in mouse serum, suggesting that PorA behaves as a putative adjuvant

“…They described that after testing various presentation forms of N. meningitidis PorA in mice, this protein (up to 10 mg per dose), using either AlPO 4 or QuilA as adjuvant, was unable to induce bactericidal antibodies when used for subcutaneous immunization. They additionally reported that bactericidal antibodies were produced with either the OMV of N. meningitidis B strain or PorA-ISCOM formulations.…”

“…1,3 However, the dynamics of meningococcal epidemiology is changing. 4 Several conjugated vaccines have been developed to control the severe consequences of infection. 5 The meningococcal group C conjugate (MenC) vaccine was developed by Chiron and Wyeth using N. meningitidis outer membrane vesicles and a genetically detoxified diphtheria toxoid (CMR197) as the adjuvant.…”

Enfermedad meningocóccica invasora por serogrupo B en dos niños chilenos vacunados contra serogrupos ACWY

“…A pesar de los avances obtenidos en el manejo del paciente crítico, la EMI continua siendo un problema de salud pública, dado su amplia distribución, perfil epidémico y alta tasa de secuelas y letalidad asociada 3 . Dentro de las teorías que explican esta situación se considera la aparición y predominio del serogrupo W observada en Chile desde 2012, con una cepa del linaje hipervirulento W:P1.5,2:ST-11, la cual contiene el alelo ID 22 para el gen fHbp, que le daría la propiedad de ser hiperinvasor 4 .…”