The changing face of cardiovascular disease 2000–2012: An analysis of the world health organisation global health estimates data

McAloon, Christopher; Boylan, Luke M; Hamborg, Thomas; Stallard, Nigel; Osman, Faizel; Lim, Phang Boon; Hayat, Sajad

doi:10.1016/j.ijcard.2016.09.026

Cited by 225 publications

(148 citation statements)

References 38 publications

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“…Despite advances in medical and surgical treatment, CVD still accounts for most noncommunicable disease (NCD) deaths all over the world [1]. CVD can originate from early life, referred to as the developmental origins of health and disease (DOHaD) [2].…”

Section: Introductionmentioning

confidence: 99%

Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease

Tain

Hsu

2017

IJMS

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Cardiovascular disease (CVD) presents a global health burden, despite recent advances in management. CVD can originate from early life by so-called “developmental origins of health and disease” (DOHaD). Epidemiological and experimental evidence supports that early-life insults can induce programming of later CVD. Underlying the DOHaD concept, early intervention may offset programming process to prevent the development of CVD, namely reprogramming. Oxidative stress and nutrient sensing signals have been considered to be major mechanisms of cardiovascular programming, while the interplay between these two mechanisms have not been examined in detail. This review summarizes current evidence that supports the link between oxidative stress and nutrient sensing signaling to cardiovascular programming, with an emphasis on the l-arginine–asymmetric dimethylarginine (ADMA)–nitric oxide (NO) pathway. This review provides an overview of evidence from human studies supporting fetal programming of CVD, insight from animal models of cardiovascular programming and oxidative stress, impact of the l-arginine–ADMA–NO pathway in cardiovascular programming, the crosstalk between l-arginine metabolism and nutrient sensing signals, and application of reprogramming interventions to prevent the programming of CVD. A greater understanding of the mechanisms underlying cardiovascular programming is essential to developing early reprogramming interventions to combat the globally growing epidemic of CVD.

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Section: Introductionmentioning

confidence: 99%

Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease

Tain

Hsu

2017

IJMS

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“…Cardiovascular disease (CVD) remains the leading cause of mortality in western societies and accounts for an estimated 31% of all deaths worldwide [1]. The most common manifestations of CVD are hypertension, coronary artery disease, stroke, and heart failure [2].…”

Section: Introductionmentioning

confidence: 99%

MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics

Tilstam

Leng

et al. 2017

Expert Opinion on Therapeutic Targets

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Introduction: Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions that is being increasingly studied in different aspects of cardiovascular disease. MIF was first identified as a proinflammatory and pro-survival mediator within the immune system, and a second structurally related MIF family member, D-dopachrome tautomerase (a.k.a. MIF-2), was reported recently. Both MIF family members are released by myocardium and modulate the manifestations of cardiovascular disease, specifically in myocardial ischemia. Areas Covered: A scientific overview is provided for the involvement of MIF family cytokines in the inflammatory pathogenesis of atherosclerosis, myocardial infarction, and ischemia-reperfusion injury. We summarize findings of experimental, human genetic and clinical studies, and suggest therapeutic opportunities for modulating the activity of MIF family proteins that potentially may be applied in a MIF allele specific manner. Expert Opinion: Knowledge of MIF, MIF-2 and their receptor pathways are under active investigation in different types of cardiovascular diseases, and novel therapeutic opportunities are being identified. Clinical translation may be accelerated by accruing experience with MIF-directed therapies currently in clinical testing in cancer and autoimmunity.

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“…According to the statistics of World Health Organization in 2012, 17.6 million people died of Cardiovascular disease (CVD) worldwide, and proportionally, this accounts for 31.43% of global mortality [3]. CVD has become the most largest and important cause of NCD deaths.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of valvular heart diseases and associated risk factors in Han, Uygur and Kazak population in Xinjiang, China

et al. 2017

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BackgroundValvular heart diseases (VHD) is very common in clinical practice and has became the subject of growing attention in the field of cardiovascular medicine. Our aim was to assess the prevalence and correlates of VHD in the general population in Xinjiang, China.MethodsUsing a 4-stage stratified cluster random sampling method, a total of 14618 participants were recruited in the Cardiovascular Risk Survey (CRS) study. The participants’ personal information, medical history were assessed by questionnaire. VHD was diagnosed by transthoracic echocardiography. We carried out the statistical analysis utilizing SPSS Statistics version 19.0.ResultsIn the total study group, VHD was observed in 1397 (9.65%) individuals. The prevalence rates of VHD in Han, Uygur and Kazak group are 13.51%, 2.71% and 12.29% respectively. The prevalence rates of VHD increased strikingly with age (all P < 0.001). The results of multinomial regression analysis indicated that VHD were related to age in Han group, to age smoking and hypertension in Uygur group, to age and hypertension in Kazak group.ConclusionOur research provides a unique prevalence rate of VHD in Xinjiang natural population. The result suggests that VHD are notably common in this population (9.65%) and increase with age. There exists significant difference of prevalence rate between ethnics. The main risk factors of VHD are age, hypertension and smoking. Valvular heart diseases should be regarded as a serious and growing public-health problem.

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The changing face of cardiovascular disease 2000–2012: An analysis of the world health organisation global health estimates data

Abstract: word count: 149None of the authors have any conflicts of interest.

Cited by 225 publications

References 38 publications

Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease

Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease

MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics

Prevalence of valvular heart diseases and associated risk factors in Han, Uygur and Kazak population in Xinjiang, China

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