The changing face of coeliac disease

Mehta, Gautam; Taslaq, Samer; Littleford, Sarah E; Bansi, Devinder S.; Thillainayagam, Andrew V.

doi:10.12968/hmed.2008.69.2.28352

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Short stature and chronic diarrhea are the most common findings in CD [1, 2]. In addition to typical malabsorption symptoms, extraintestinal manifestations like skin lesions, osteoporosis, elevated transaminases, and hematological manifestations can be first findings of CD [2, 3]. Also, CD can be associated with autoimmune disorders [4].…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease Presenting with Immune Thrombocytopenic Purpura

Sarbay

Akın

et al. 2017

Case Reports in Hematology

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Section: Introductionmentioning

confidence: 99%

Celiac Disease Presenting with Immune Thrombocytopenic Purpura

Sarbay

Akın

et al. 2017

Case Reports in Hematology

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“…Growth retardation and chronic diarrhea are the most frequently seen manifestations [ 3 ]. In addition to the typical findings of malabsorption, many autoimmunological disorders may accompany the disease, or there may be extraintestinal findings, such as growth retardation, developmental delay, impaired hepatic function, skin manifestations, osteoporosis, or hematological disorders [ 4 , 5 ]. As a result of having similar autoimmune mechanisms, in some publications, CD has been reported as a risk factor for ITP [ 6 ].…”

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confidence: 99%

Investigation of Celiac Disease in Patients Followed by Immun Thrombocytopenic Purpura Diagnosis and Comparison with Literature

Sarbay

Kocamaz

Akın

et al. 2017

North Clin Istanbul

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OBJECTIVE:Celiac disease (CD) and Immune thrombocytopenic purpura (ITP) may occur together as a result of similar autoimmune mechanisms. The aim of this study was to assess the frequency of CD in a group of ITP patients and in the literature.METHODS:A total of 29 patients in Pamukkale University Faculty of Medicine Hospital Pediatric Hematology and Oncology Department with ITP were included in the study. Test was performed for the antibodies related to CD. Positive result for celiac antibodies was confirmed with biopsy. The results were compared with the literature.RESULTS:Of the study group, 13 patients (44.8%) were female and 16 (55.2%) were male. The mean age was 7.2±4.7 years and mean platelet count at the time of admission was 13,440±11,110/mm3 (range: 2000-41,000/mm3). Twelve patients (41.4%) were diagnosed as acute ITP, 6 patients (20.7%) as persistent ITP, and 11 patients (37.9%) as chronic ITP, according to the duration of thrombocytopenia. Antibody positivity was detected in 1 patient. Histological evaluation was compatible with CD. Results were compared with studies regarding the prevalence of CD in the population. No significant difference was found.CONCLUSION:Although it is not necessary to perform CD test in every case of ITP, the presence of differential diagnosis of CD is important to prevent unnecessary treatment, especially in ITP patients with growth retardation or malabsorption findings.

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“…In these patients, some variants in Human Leucocyte Antigen (HLA) region represent the genetic predisposition for the development of the disease. CD‐related HLA DQ2 and/or DQ8 aplotypes preferentially present gluten antigens to CD4+ T cells that, in turn, activate both humoral and cellular immune‐inflammatory response, with production of autoantibody and pro‐inflammatory cytokines, respectively (Mehta, Taslaq, Littleford, Bansi, & Thillainayagam, ). In CD‐patients, the increased Reactive Oxygen Species (ROS) is not adequately offset by an antioxidant defence.…”

Section: Introductionmentioning

confidence: 99%

Mesalazine treatment in organotypic culture of celiac patients: Comparative study with gluten free diet

Benedetti

Castelli

Maggiani

et al. 2018

Journal Cellular Physiology

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Given the central role of gluten in the pathogenesis of celiac disease (CD), a strict gluten-free diet (GFD) is the only validated treatment able to restore epithelium integrity and eliminate risks of complications. The risk of gluten contamination and the persistence of inflammation, even in patients strictly adhering to GFD, may render this treatment not always effective claiming the necessity of different new solutions. Oxidative and nitrosative stress have been indicated to play a pathophysiological role in CD. Mesalazine (5-ASA), a drug largely used in inflammatory bowel disease, has potent antinflammatory and antioxidant effects. In fact, mesalazine has been shown to decrease in vitro gluten induced cytokine response and it has been used in vivo in some refractory condition. However, its effect has never compared to that of GFD. The present study aimed to address this issue by comparing the ability of mesalazine and GFD in treating gluten-induced inflammation and oxidative stress. These effects were studied on duodenal mucosa biopsy cultures from newly diagnosed CD patients, treated or not in vitro with mesalazine, and CD biopsy cultures from patients on gluten-free diet for at least one year; and a cohort of controls constituted by healty subjects. On these models, the antioxidant cellular defences, the PPARγ, NF-kB and NOS2 proteins levels were studied. This study shows that mesalazine is as effective as GFD in reducing oxidative burst and inducing PPARγ expression; moreover it resulted more effective than GFD in decreasing NF-kB and NOS2 to the levels of controls.

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The changing face of coeliac disease

Cited by 7 publications

References 20 publications

Celiac Disease Presenting with Immune Thrombocytopenic Purpura

Celiac Disease Presenting with Immune Thrombocytopenic Purpura

Investigation of Celiac Disease in Patients Followed by Immun Thrombocytopenic Purpura Diagnosis and Comparison with Literature

Mesalazine treatment in organotypic culture of celiac patients: Comparative study with gluten free diet

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