The Changing Frequency of Celiac Disease Diagnosed at the Stollery Children’s Hospital

Rajani, Seema; Huynh, Hien Q.; Turner, Justine

doi:10.1155/2010/968062

Cited by 14 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An ‘epidemic’ of CD was described in Sweden from 1985 to 1995, possibly related to a doubling of gluten content in baby food at that time. Two Canadian studies reported several fold increases in the number of children diagnosed with CD from the 1990s to the 2000s . These increases were attributed to greater awareness and the introduction of serological tests and screening.…”

Section: Resultsmentioning

confidence: 99%

“…Two Canadian studies reported several fold increases in the number of children diagnosed with CD from the 1990s to the 2000s. 214,215 These increases were attributed to greater awareness and the introduction of serological tests and screening. An Italian study, using 'prescription charge exemption for CD-oriented drugs' as proxy for CD, reported a stable incidence from 2002 to 2010, but a consistent increase in prevalence from 2002 to 2010.…”

Section: Incidence and Prevalence Of Clinically Diagnosed CD (Tables mentioning

confidence: 99%

See 1 more Smart Citation

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

231

182

View full text Add to dashboard Cite

Summary Background Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub‐Saharan Africa. Aim To assess geographical differences and time trends in the frequency of CD. Methods Medline and Embase searches were conducted on 10 November 2012, from 1946 and 1980 respectively, using the key words: coeliac disease or celiac disease + prevalence or incidence or frequency. Results There were significant intra‐ and inter‐country differences in the prevalence and incidence of CD. Only 24 ethnic Chinese and Japanese patients have been reported in the English literature. Of CD‐associated HLA DQ antigens, DQ2 occurs in 5–10% of Chinese and sub‐Saharan Africans, compared to 5–20% in Western Europe. DQ8 occurs in 5–10% of English, Tunisians and Iranians, but in <5% of Eastern Europeans, Americans and Asians. The prevalence and incidence of both clinically and serologically diagnosed CD increased in recent years. These geographical and temporal differences seem genuine, although variable indices of suspicion and availability of diagnostic facilities are confounding factors. Conclusions Coeliac disease is increasing in frequency, with significant geographical differences. Although few cases have been described to date in the Orient and Sub‐Saharan Africa, there is a significant prevalence of HLA DQ2 and wheat consumption is of the same order as that in Western Europe. CD may therefore become more common in the future in these countries.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Incidence and Prevalence Of Clinically Diagnosed CD (Tables mentioning

confidence: 99%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

231

182

View full text Add to dashboard Cite

show abstract

“…Screening for CD in the presence of risk factors, such as family history or type I diabetes, short stature, iron deficiency or idiopathic osteoporosis is warranted. Our previous clinical experience indicates that between 40 and 55% of symptomatic and asymptomatic children with CD had low bone mineral density (BMD) at diagnosis and that recovery after 1 year of treatment on the gluten-free diet (GFD) was incomplete; a worrisome finding given that critical bone accrual occurs during childhood and adolescence (Bailey, 1997;Turner et al, 2009;Rajani et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease

2011

View full text Add to dashboard Cite

Background/Objectives: Children with celiac disease (CD) are at risk for decreased bone mineral density (BMD) because of fat-soluble vitamin malabsorption, inflammation and/or under-nutrition. The study objective was to determine the interrelationships between vitamin K/D status and lifestyle variables on BMD in children and adolescents with CD at diagnosis and after 1 year on the gluten-free diet (GFD). Subjects/Methods: Children and adolescents aged 3-17 years with biopsy proven CD at diagnosis and after 1 year on the GFD were studied. BMD was measured using dual-energy X-ray absorptiometry. Relevant variables included: anthropometrics, vitamin D/K status, diet, physical activity and sunlight exposure. Results: Whole-body and lumbar-spine BMD-z scores were low (pÀ1) at diagnosis (10-20%) and after 1 year (30-32%) in the children, independent of symptoms. Whole-body BMD-z scores (À0.55±0.7 versus 0.72±1.5) and serum levels of 25(OH) vitamin D (90.3 ± 24.8 versus 70.5 ± 19.8 nmol/l) were significantly lower in older children (410 years) when compared with younger children (p10 years) (Po0.001). Forty-three percent had suboptimal vitamin D status (25(OH)-vitamin D o75 nmol/l) at diagnosis; resolving in nearly half after 1 year on the GFD. Twenty-five percent had suboptimal vitamin K status at diagnosis; all resolved after 1 year. Conclusions: Children and adolescents with CD are at risk for suboptimal bone health at time of diagnosis and after 1 year on GFD; likely due in part to suboptimal vitamin D/K status. Therapeutic strategies aimed at optimizing vitamin K/D intake may contribute to improved BMD in children with CD.

show abstract

“…Given an estimated population prevalence of CD of 1% and EoE of 0.04% (10), the prevalence of patients having EoE and CD being 4.4% of the CD patients does appear to be higher than expected. A recent study conducted at the Stollery Children's Hospital (12) found an 11-fold increase in the diagnoses of CD over a four-year period, suggesting that increased prevalence rates could very well be due to an increase in detection rates. Nonetheless, this association between the two diseases warrants far more consideration because it may shed light on the pathogenesis of each condition.…”

Section: Discussionmentioning

confidence: 99%

Gluten-Free Diet Does Not Appear to Induce Endoscopic Remission of Eosinophilic Esophagitis in Children with Coexistent Celiac Disease

Abraham

Persad

Turner

et al. 2012

Canadian Journal of Gastroenterology

Self Cite

View full text Add to dashboard Cite

show abstract

The Changing Frequency of Celiac Disease Diagnosed at the Stollery Children’s Hospital

Cited by 14 publications

References 13 publications

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease

Gluten-Free Diet Does Not Appear to Induce Endoscopic Remission of Eosinophilic Esophagitis in Children with Coexistent Celiac Disease

Contact Info

Product

Resources

About