The changing landscape of cardiac metabolism

Davogustto, Giovanni; Taegtmeyer, Heinrich

doi:10.1016/j.yjmcc.2015.04.021

Cited by 5 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A fitting example is acetyl-CoA, a prototype link between metabolism and epigenetic modifications. 419 As analytical tools become more diverse, their strategic deployment becomes imperative in the search for novel cellular mechanisms underpinning the function of the heart in the pursuit of novel targets for drugs, and even for cardiovascular risk stratification. In a brief sketch on the evolution of metabolism, the late Larry Holmes wrote, “Criteria were set out and guided scientists through years of detailed investigation of a special part of nature before these investigations attained any success dramatic enough to qualify as a paradigm.…”

Section: Metabolic Signaling In Heart Disease: the Enduring Need For mentioning

confidence: 99%

Assessing Cardiac Metabolism

Taegtmeyer¹,

Young²,

Lopaschuk³

et al. 2016

Circulation Research

Self Cite

237

147

View full text Add to dashboard Cite

In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart’s needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on “Assessing Cardiac Metabolism” seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism. Some of those methods are refinements of classic biochemical tools, whereas most others are recent additions from the powerful tools of molecular biology. The aim of this statement is to be useful to many and to do justice to a dynamic field of great complexity.

show abstract

Section: Metabolic Signaling In Heart Disease: the Enduring Need For mentioning

confidence: 99%

Assessing Cardiac Metabolism

Taegtmeyer¹,

Young²,

Lopaschuk³

et al. 2016

Circulation Research

Self Cite

237

147

View full text Add to dashboard Cite

show abstract

“…Fourth, the results support the concept of long-term regulation of gene expression in a model of maternal-fetal parabiosis. In other words, the offspring’s heart carries a “metabolic memory,” reflecting the metabolic, structural, and functional rewiring of the fetal heart through post-transcriptional modifications of processes and/or transcriptional modifications of DNA and RNA (7), in other words, the interactions of genes with their environment from the molecular basis for profound structural and functional changes of the heart. The concept of epigenetic regulation has received recent attention in the developing and failing heart (8).…”

mentioning

confidence: 99%

Maternal-Fetal Parabiosis in Obesity Exposes Unexpected Roles for Cardiac Metabolism

Taegtmeyer

2018

JACC: Cardiovascular Imaging

Self Cite

View full text Add to dashboard Cite

Cardiac Metabolism in Perspective

Taegtmeyer

Lam

Davogustto

2016

Comprehensive Physiology

View full text Add to dashboard Cite

The heart is a biological pump that converts chemical to mechanical energy. This process of energy conversion is highly regulated to the extent that energy substrate metabolism matches energy use for contraction on a beat-to-beat basis. The biochemistry of cardiac metabolism includes the biochemistry of energy transfer, metabolic regulation, and transcriptional, translational as well as posttranslational control of enzymatic activities. Pathways of energy substrate metabolism in the heart are complex and dynamic, but all of them conform to the First Law of Thermodynamics. The perspectives expand on the overall idea that cardiac metabolism is inextricably linked to both physiology and molecular biology of the heart. The article ends with an outlook on emerging concepts of cardiac metabolism based on new molecular models and new analytical tools. © 2016 American Physiological Society. Compr Physiol 6:1675-1699, 2016.

show abstract

The changing landscape of cardiac metabolism

Cited by 5 publications

References 44 publications

Assessing Cardiac Metabolism

Assessing Cardiac Metabolism

Maternal-Fetal Parabiosis in Obesity Exposes Unexpected Roles for Cardiac Metabolism

Cardiac Metabolism in Perspective

Contact Info

Product

Resources

About