The changing role of descending control of spinal nociception over postnatal development

Battell, Emma E.; Lillywhite, Amanda; Hathway, Gareth J.

doi:10.1016/j.cophys.2019.08.003

Cited by 6 publications

(3 citation statements)

References 36 publications

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“… 66 In adult rodents, nociceptive C-fiber input is tonically inhibited (although this shifts to facilitation following injury), whereas at younger ages there is a relative excess of facilitation. 67 , 68 The delayed maturation of inhibitory mechanisms is influenced by endogenous opioid and endocannabinoid signaling, 69 and surgical injury in neonatal rodents produces long-term changes in the balance of inhibitory/facilitatory modulation. 70 …”

Section: Developmental Mechanisms Of Acute and Chronic Surgical Painmentioning

confidence: 99%

Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations

Walker

2021

Canadian Journal of Pain

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Understanding mechanisms that underly the transition from acute to chronic pain and identifying potential targets for preventing or minimizing this progression have specific relevance for chronic postsurgical pain (CPSP). Though it is clear that multiple psychosocial, family, and environmental factors may influence CPSP, this review will focus on parallels between clinical observations and translational laboratory studies investigating the acute and long-term effects of surgical injury on nociceptive pathways. This includes data related to alterations in sensitivity at different points along nociceptive pathways from the periphery to the brain; age- and sex-dependent mechanisms underlying the transition from acute to persistent pain; potential targets for preventive interventions; and the impact of prior surgical injury. Ongoing preclinical studies evaluating age- and sex-dependent mechanisms will also inform comparative efficacy and preclinical safety assessments of potential preventive pharmacological interventions aimed at reducing the risk of CPSP. In future clinical studies, more detailed and longitudinal peri-operative phenotyping with patient- and parent-reported chronic pain core outcomes, alongside more specialized evaluations of somatosensory function, modulation, and circuitry, may enhance understanding of individual variability in postsurgical pain trajectories and improve recognition and management of CPSP.

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Section: Developmental Mechanisms Of Acute and Chronic Surgical Painmentioning

confidence: 99%

Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations

Walker

2021

Canadian Journal of Pain

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“…35 Furthermore, we have recently shown that the 5-HT 2A receptor plays a key role in morphological remodeling of PKCg 1 interneurons in a pathological context. 2 Because 5-HT afferents gradually contact the SDH during the first postnatal weeks, 10,15 it is therefore possible that a postnatal establishment of 5-HT inputs within the MDH plays a role in the primary branches lengthening of PKCg 1 interneurons. Many research groups have investigated the morphology or electrophysiology of neurons.…”

Section: Morphological Maturation Of the Medullary Dorsal Horn Lamina...mentioning

confidence: 99%

Postnatal development of inner lamina II interneurons of the rat medullary dorsal horn

Mermet-Joret

Alba-Delgado

Descheemaeker

et al. 2021

Pain

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Pain processing in young mammals is immature. Despite the central role of the medullary dorsal horn (MDH) in processing orofacial sensory information, the maturation of the neurons within the MDH has been largely overlooked. Combining in vitro electrophysiological recordings and 3D morphological analysis over the first postnatal month in rats, we investigated the agedependent development of the neurons within the inner lamina II (IIi) of the MDH. We show the lamina IIi neuronal population transition into a more hyperpolarized state, with modification of the action potential waveform, and a shift from single spiking, at early postnatal ages, to tonic firing and initial bursting at later stages. These physiological changes are associated with a strong structural remodelling of the neuronal morphology with most of the modifications occurring after the third postnatal week. Among the lamina IIi neuronal population, the subpopulation of interneurons expressing the g isoform of the protein kinase C (PKCg 1 ) are key elements for the circuits underlying facial mechanical allodynia. How do they develop from the rest of the lamina IIi constitute an important question that remained to be addressed. Here, we show that PKCg 1 interneurons display electrophysiological changes over time comparable with the PKCg 2 population. However, they show a distinctive increase of the soma volume and primary branches length, as opposed to the PKCg 2 population. Together, our data demonstrate a novel pattern of late postnatal maturation of lamina IIi interneurons, with a spotlight on PKCg 1 interneurons, that may be relevant for the development of orofacial sensitivity.

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“…1,11 Preclinical studies in rodents indicate that descending inhibitory modulation of the nociceptive signaling is still immature immediate around birth, especially in preterm newborns, and will switch from facilitation to inhibition during the first 3 postnatal weeks. [15][16][17][18][19] Notably, the rostral ventral medulla (RVM) is the major source of descending serotonergic modulation of spinal nociception and has been shown to enhance rather than inhibit nociceptive stimuli in early life in rodents. 17 These descending serotonergic projections and their receptors are targeted for pharmacological treatment of pain in adults due to their expression in the spinal dorsal horn 20 and could also potentially be utilized to attenuate the acute effects of overstimulation of the nociceptive system at an early age.…”

Section: Introductionmentioning

confidence: 99%

The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective

et al. 2021

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The changing role of descending control of spinal nociception over postnatal development

Cited by 6 publications

References 36 publications

Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations

Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations

Postnatal development of inner lamina II interneurons of the rat medullary dorsal horn

The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective

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